Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	123745
Gene name	Phospholipase A2 group IVE
Gene symbol	PLA2G4E
Synonyms (NCBI Gene)	-
Chromosome	15
Chromosome location	15q15.1
Summary	This gene encodes a member of the cytosolic phospholipase A2 group IV family. Members of this family are involved in regulation of membrane tubule-mediated transport. The enzyme encoded by this member of the family plays a role in trafficking through the

291 Show/Hide all (291)

miRTarBase ID	miRNA	Experiments	Reference
MIRT662208	hsa-miR-4282	HITS-CLIP	23824327
MIRT662207	hsa-miR-345-5p	HITS-CLIP	23824327
MIRT662206	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT662205	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT662203	hsa-miR-4256	HITS-CLIP	23824327
MIRT662204	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT662208	hsa-miR-4282	HITS-CLIP	23824327
MIRT662207	hsa-miR-345-5p	HITS-CLIP	23824327
MIRT662206	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT662205	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT662203	hsa-miR-4256	HITS-CLIP	23824327
MIRT662204	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT1238728	hsa-miR-1254	CLIP-seq
MIRT1238729	hsa-miR-1273e	CLIP-seq
MIRT1238730	hsa-miR-1285	CLIP-seq
MIRT1238731	hsa-miR-1301	CLIP-seq
MIRT1238732	hsa-miR-1827	CLIP-seq
MIRT1238733	hsa-miR-1915	CLIP-seq
MIRT1238734	hsa-miR-2467-3p	CLIP-seq
MIRT1238735	hsa-miR-25	CLIP-seq
MIRT1238736	hsa-miR-2964a-3p	CLIP-seq
MIRT1238737	hsa-miR-302f	CLIP-seq
MIRT1238738	hsa-miR-31	CLIP-seq
MIRT1238739	hsa-miR-3116	CLIP-seq
MIRT1238740	hsa-miR-3122	CLIP-seq
MIRT1238741	hsa-miR-3123	CLIP-seq
MIRT1238742	hsa-miR-3165	CLIP-seq
MIRT1238743	hsa-miR-3180-5p	CLIP-seq
MIRT1238744	hsa-miR-3187-5p	CLIP-seq
MIRT1238745	hsa-miR-32	CLIP-seq
MIRT1238746	hsa-miR-3612	CLIP-seq
MIRT1238747	hsa-miR-3622a-3p	CLIP-seq
MIRT1238748	hsa-miR-3622b-3p	CLIP-seq
MIRT1238749	hsa-miR-363	CLIP-seq
MIRT1238750	hsa-miR-3657	CLIP-seq
MIRT1238751	hsa-miR-3665	CLIP-seq
MIRT1238752	hsa-miR-367	CLIP-seq
MIRT1238753	hsa-miR-3672	CLIP-seq
MIRT1238754	hsa-miR-3689a-3p	CLIP-seq
MIRT1238755	hsa-miR-3689c	CLIP-seq
MIRT1238756	hsa-miR-3913-5p	CLIP-seq
MIRT1238757	hsa-miR-4257	CLIP-seq
MIRT1238758	hsa-miR-4325	CLIP-seq
MIRT1238759	hsa-miR-4433	CLIP-seq
MIRT1238760	hsa-miR-4446-5p	CLIP-seq
MIRT1238761	hsa-miR-4459	CLIP-seq
MIRT1238762	hsa-miR-4537	CLIP-seq
MIRT1238763	hsa-miR-4660	CLIP-seq
MIRT1238764	hsa-miR-4669	CLIP-seq
MIRT1238765	hsa-miR-4726-3p	CLIP-seq
MIRT1238766	hsa-miR-4728-5p	CLIP-seq
MIRT1238767	hsa-miR-4735-5p	CLIP-seq
MIRT1238768	hsa-miR-4736	CLIP-seq
MIRT1238769	hsa-miR-4763-5p	CLIP-seq
MIRT1238770	hsa-miR-4768-3p	CLIP-seq
MIRT1238771	hsa-miR-4768-5p	CLIP-seq
MIRT1238772	hsa-miR-4797-5p	CLIP-seq
MIRT1238773	hsa-miR-486-5p	CLIP-seq
MIRT1238774	hsa-miR-490-3p	CLIP-seq
MIRT1238775	hsa-miR-5047	CLIP-seq
MIRT1238776	hsa-miR-508-5p	CLIP-seq
MIRT1238777	hsa-miR-520a-5p	CLIP-seq
MIRT1238778	hsa-miR-525-5p	CLIP-seq
MIRT1238779	hsa-miR-544b	CLIP-seq
MIRT1238780	hsa-miR-576-5p	CLIP-seq
MIRT1238781	hsa-miR-612	CLIP-seq
MIRT1238782	hsa-miR-650	CLIP-seq
MIRT1238783	hsa-miR-661	CLIP-seq
MIRT1238784	hsa-miR-759	CLIP-seq
MIRT1238785	hsa-miR-766	CLIP-seq
MIRT1238786	hsa-miR-92a	CLIP-seq
MIRT1238787	hsa-miR-92b	CLIP-seq
MIRT1238788	hsa-miR-940	CLIP-seq
MIRT2070250	hsa-miR-1273f	CLIP-seq
MIRT1238732	hsa-miR-1827	CLIP-seq
MIRT2070251	hsa-miR-185	CLIP-seq
MIRT1238736	hsa-miR-2964a-3p	CLIP-seq
MIRT2070252	hsa-miR-3135b	CLIP-seq
MIRT2070253	hsa-miR-3929	CLIP-seq
MIRT2070254	hsa-miR-4252	CLIP-seq
MIRT2070255	hsa-miR-4284	CLIP-seq
MIRT2070256	hsa-miR-4306	CLIP-seq
MIRT2070257	hsa-miR-4419b	CLIP-seq
MIRT2070258	hsa-miR-4478	CLIP-seq
MIRT2070259	hsa-miR-4644	CLIP-seq
MIRT2070260	hsa-miR-485-5p	CLIP-seq
MIRT1238729	hsa-miR-1273e	CLIP-seq
MIRT1238730	hsa-miR-1285	CLIP-seq
MIRT1238732	hsa-miR-1827	CLIP-seq
MIRT2297525	hsa-miR-24	CLIP-seq
MIRT1238734	hsa-miR-2467-3p	CLIP-seq
MIRT1238735	hsa-miR-25	CLIP-seq
MIRT1238736	hsa-miR-2964a-3p	CLIP-seq
MIRT1238737	hsa-miR-302f	CLIP-seq
MIRT1238738	hsa-miR-31	CLIP-seq
MIRT1238740	hsa-miR-3122	CLIP-seq
MIRT1238741	hsa-miR-3123	CLIP-seq
MIRT1238742	hsa-miR-3165	CLIP-seq
MIRT1238743	hsa-miR-3180-5p	CLIP-seq
MIRT1238744	hsa-miR-3187-5p	CLIP-seq
MIRT2297526	hsa-miR-3192	CLIP-seq
MIRT1238745	hsa-miR-32	CLIP-seq
MIRT1238746	hsa-miR-3612	CLIP-seq
MIRT1238747	hsa-miR-3622a-3p	CLIP-seq
MIRT1238748	hsa-miR-3622b-3p	CLIP-seq
MIRT1238749	hsa-miR-363	CLIP-seq
MIRT1238751	hsa-miR-3665	CLIP-seq
MIRT1238752	hsa-miR-367	CLIP-seq
MIRT1238754	hsa-miR-3689a-3p	CLIP-seq
MIRT1238755	hsa-miR-3689c	CLIP-seq
MIRT1238756	hsa-miR-3913-5p	CLIP-seq
MIRT2070253	hsa-miR-3929	CLIP-seq
MIRT1238757	hsa-miR-4257	CLIP-seq
MIRT2070255	hsa-miR-4284	CLIP-seq
MIRT1238758	hsa-miR-4325	CLIP-seq
MIRT2070257	hsa-miR-4419b	CLIP-seq
MIRT1238759	hsa-miR-4433	CLIP-seq
MIRT1238761	hsa-miR-4459	CLIP-seq
MIRT2070258	hsa-miR-4478	CLIP-seq
MIRT1238762	hsa-miR-4537	CLIP-seq
MIRT2297527	hsa-miR-4649-3p	CLIP-seq
MIRT1238766	hsa-miR-4728-5p	CLIP-seq
MIRT1238768	hsa-miR-4736	CLIP-seq
MIRT1238770	hsa-miR-4768-3p	CLIP-seq
MIRT1238772	hsa-miR-4797-5p	CLIP-seq
MIRT2070260	hsa-miR-485-5p	CLIP-seq
MIRT1238774	hsa-miR-490-3p	CLIP-seq
MIRT1238776	hsa-miR-508-5p	CLIP-seq
MIRT1238777	hsa-miR-520a-5p	CLIP-seq
MIRT1238778	hsa-miR-525-5p	CLIP-seq
MIRT1238779	hsa-miR-544b	CLIP-seq
MIRT1238781	hsa-miR-612	CLIP-seq
MIRT1238782	hsa-miR-650	CLIP-seq
MIRT1238783	hsa-miR-661	CLIP-seq
MIRT1238784	hsa-miR-759	CLIP-seq
MIRT1238785	hsa-miR-766	CLIP-seq
MIRT1238786	hsa-miR-92a	CLIP-seq
MIRT1238787	hsa-miR-92b	CLIP-seq
MIRT1238788	hsa-miR-940	CLIP-seq
MIRT1238729	hsa-miR-1273e	CLIP-seq
MIRT1238732	hsa-miR-1827	CLIP-seq
MIRT1238734	hsa-miR-2467-3p	CLIP-seq
MIRT1238736	hsa-miR-2964a-3p	CLIP-seq
MIRT1238737	hsa-miR-302f	CLIP-seq
MIRT1238738	hsa-miR-31	CLIP-seq
MIRT1238740	hsa-miR-3122	CLIP-seq
MIRT1238741	hsa-miR-3123	CLIP-seq
MIRT1238742	hsa-miR-3165	CLIP-seq
MIRT2297526	hsa-miR-3192	CLIP-seq
MIRT1238746	hsa-miR-3612	CLIP-seq
MIRT1238747	hsa-miR-3622a-3p	CLIP-seq
MIRT1238748	hsa-miR-3622b-3p	CLIP-seq
MIRT1238751	hsa-miR-3665	CLIP-seq
MIRT1238754	hsa-miR-3689a-3p	CLIP-seq
MIRT1238755	hsa-miR-3689c	CLIP-seq
MIRT1238756	hsa-miR-3913-5p	CLIP-seq
MIRT1238757	hsa-miR-4257	CLIP-seq
MIRT1238759	hsa-miR-4433	CLIP-seq
MIRT1238761	hsa-miR-4459	CLIP-seq
MIRT1238762	hsa-miR-4537	CLIP-seq
MIRT1238766	hsa-miR-4728-5p	CLIP-seq
MIRT1238768	hsa-miR-4736	CLIP-seq
MIRT1238770	hsa-miR-4768-3p	CLIP-seq
MIRT1238774	hsa-miR-490-3p	CLIP-seq
MIRT1238779	hsa-miR-544b	CLIP-seq
MIRT1238782	hsa-miR-650	CLIP-seq
MIRT1238788	hsa-miR-940	CLIP-seq
MIRT1238729	hsa-miR-1273e	CLIP-seq
MIRT1238732	hsa-miR-1827	CLIP-seq
MIRT1238736	hsa-miR-2964a-3p	CLIP-seq
MIRT1238737	hsa-miR-302f	CLIP-seq
MIRT1238738	hsa-miR-31	CLIP-seq
MIRT1238740	hsa-miR-3122	CLIP-seq
MIRT1238741	hsa-miR-3123	CLIP-seq
MIRT1238742	hsa-miR-3165	CLIP-seq
MIRT2297526	hsa-miR-3192	CLIP-seq
MIRT1238746	hsa-miR-3612	CLIP-seq
MIRT1238747	hsa-miR-3622a-3p	CLIP-seq
MIRT1238748	hsa-miR-3622b-3p	CLIP-seq
MIRT1238751	hsa-miR-3665	CLIP-seq
MIRT1238754	hsa-miR-3689a-3p	CLIP-seq
MIRT1238755	hsa-miR-3689c	CLIP-seq
MIRT1238756	hsa-miR-3913-5p	CLIP-seq
MIRT1238759	hsa-miR-4433	CLIP-seq
MIRT1238761	hsa-miR-4459	CLIP-seq
MIRT1238766	hsa-miR-4728-5p	CLIP-seq
MIRT1238768	hsa-miR-4736	CLIP-seq
MIRT1238770	hsa-miR-4768-3p	CLIP-seq
MIRT1238774	hsa-miR-490-3p	CLIP-seq
MIRT1238779	hsa-miR-544b	CLIP-seq
MIRT1238782	hsa-miR-650	CLIP-seq
MIRT1238788	hsa-miR-940	CLIP-seq
MIRT1238729	hsa-miR-1273e	CLIP-seq
MIRT1238730	hsa-miR-1285	CLIP-seq
MIRT1238732	hsa-miR-1827	CLIP-seq
MIRT2594905	hsa-miR-1908	CLIP-seq
MIRT2297525	hsa-miR-24	CLIP-seq
MIRT1238734	hsa-miR-2467-3p	CLIP-seq
MIRT1238735	hsa-miR-25	CLIP-seq
MIRT1238736	hsa-miR-2964a-3p	CLIP-seq
MIRT1238737	hsa-miR-302f	CLIP-seq
MIRT1238738	hsa-miR-31	CLIP-seq
MIRT1238740	hsa-miR-3122	CLIP-seq
MIRT1238741	hsa-miR-3123	CLIP-seq
MIRT1238742	hsa-miR-3165	CLIP-seq
MIRT1238743	hsa-miR-3180-5p	CLIP-seq
MIRT1238744	hsa-miR-3187-5p	CLIP-seq
MIRT2297526	hsa-miR-3192	CLIP-seq
MIRT1238745	hsa-miR-32	CLIP-seq
MIRT1238746	hsa-miR-3612	CLIP-seq
MIRT2594906	hsa-miR-3613-3p	CLIP-seq
MIRT1238747	hsa-miR-3622a-3p	CLIP-seq
MIRT1238748	hsa-miR-3622b-3p	CLIP-seq
MIRT2594907	hsa-miR-3622b-5p	CLIP-seq
MIRT1238749	hsa-miR-363	CLIP-seq
MIRT1238751	hsa-miR-3665	CLIP-seq
MIRT1238752	hsa-miR-367	CLIP-seq
MIRT1238753	hsa-miR-3672	CLIP-seq
MIRT1238754	hsa-miR-3689a-3p	CLIP-seq
MIRT1238755	hsa-miR-3689c	CLIP-seq
MIRT1238756	hsa-miR-3913-5p	CLIP-seq
MIRT2594908	hsa-miR-3945	CLIP-seq
MIRT2594909	hsa-miR-4253	CLIP-seq
MIRT1238757	hsa-miR-4257	CLIP-seq
MIRT2070255	hsa-miR-4284	CLIP-seq
MIRT1238758	hsa-miR-4325	CLIP-seq
MIRT1238759	hsa-miR-4433	CLIP-seq
MIRT1238761	hsa-miR-4459	CLIP-seq
MIRT1238762	hsa-miR-4537	CLIP-seq
MIRT1238766	hsa-miR-4728-5p	CLIP-seq
MIRT1238768	hsa-miR-4736	CLIP-seq
MIRT1238770	hsa-miR-4768-3p	CLIP-seq
MIRT1238772	hsa-miR-4797-5p	CLIP-seq
MIRT1238774	hsa-miR-490-3p	CLIP-seq
MIRT1238776	hsa-miR-508-5p	CLIP-seq
MIRT1238777	hsa-miR-520a-5p	CLIP-seq
MIRT1238778	hsa-miR-525-5p	CLIP-seq
MIRT1238779	hsa-miR-544b	CLIP-seq
MIRT2594910	hsa-miR-548c-3p	CLIP-seq
MIRT1238781	hsa-miR-612	CLIP-seq
MIRT1238782	hsa-miR-650	CLIP-seq
MIRT1238783	hsa-miR-661	CLIP-seq
MIRT2594911	hsa-miR-663	CLIP-seq
MIRT1238784	hsa-miR-759	CLIP-seq
MIRT1238785	hsa-miR-766	CLIP-seq
MIRT1238786	hsa-miR-92a	CLIP-seq
MIRT1238787	hsa-miR-92b	CLIP-seq
MIRT1238788	hsa-miR-940	CLIP-seq
MIRT1238729	hsa-miR-1273e	CLIP-seq
MIRT1238730	hsa-miR-1285	CLIP-seq
MIRT1238732	hsa-miR-1827	CLIP-seq
MIRT2297525	hsa-miR-24	CLIP-seq
MIRT1238735	hsa-miR-25	CLIP-seq
MIRT1238736	hsa-miR-2964a-3p	CLIP-seq
MIRT1238737	hsa-miR-302f	CLIP-seq
MIRT1238738	hsa-miR-31	CLIP-seq
MIRT1238740	hsa-miR-3122	CLIP-seq
MIRT1238741	hsa-miR-3123	CLIP-seq
MIRT1238742	hsa-miR-3165	CLIP-seq
MIRT1238743	hsa-miR-3180-5p	CLIP-seq
MIRT1238744	hsa-miR-3187-5p	CLIP-seq
MIRT2297526	hsa-miR-3192	CLIP-seq
MIRT1238745	hsa-miR-32	CLIP-seq
MIRT1238746	hsa-miR-3612	CLIP-seq
MIRT1238747	hsa-miR-3622a-3p	CLIP-seq
MIRT1238748	hsa-miR-3622b-3p	CLIP-seq
MIRT1238749	hsa-miR-363	CLIP-seq
MIRT1238751	hsa-miR-3665	CLIP-seq
MIRT1238752	hsa-miR-367	CLIP-seq
MIRT1238754	hsa-miR-3689a-3p	CLIP-seq
MIRT1238755	hsa-miR-3689c	CLIP-seq
MIRT1238756	hsa-miR-3913-5p	CLIP-seq
MIRT2070255	hsa-miR-4284	CLIP-seq
MIRT1238758	hsa-miR-4325	CLIP-seq
MIRT1238759	hsa-miR-4433	CLIP-seq
MIRT1238761	hsa-miR-4459	CLIP-seq
MIRT1238766	hsa-miR-4728-5p	CLIP-seq
MIRT1238768	hsa-miR-4736	CLIP-seq
MIRT1238770	hsa-miR-4768-3p	CLIP-seq
MIRT1238774	hsa-miR-490-3p	CLIP-seq
MIRT1238776	hsa-miR-508-5p	CLIP-seq
MIRT1238777	hsa-miR-520a-5p	CLIP-seq
MIRT1238778	hsa-miR-525-5p	CLIP-seq
MIRT1238779	hsa-miR-544b	CLIP-seq
MIRT1238781	hsa-miR-612	CLIP-seq
MIRT1238782	hsa-miR-650	CLIP-seq
MIRT1238783	hsa-miR-661	CLIP-seq
MIRT1238785	hsa-miR-766	CLIP-seq
MIRT1238786	hsa-miR-92a	CLIP-seq
MIRT1238787	hsa-miR-92b	CLIP-seq
MIRT1238788	hsa-miR-940	CLIP-seq

40 Show/Hide all (40)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004620	Function	Phospholipase activity	IEA
GO:0004623	Function	Phospholipase A2 activity	IEA
GO:0005509	Function	Calcium ion binding	IBA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	ISS
GO:0005547	Function	Phosphatidylinositol-3,4,5-trisphosphate binding	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005765	Component	Lysosomal membrane	ISS
GO:0005768	Component	Endosome	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006650	Process	Glycerophospholipid metabolic process	IEA
GO:0008970	Function	Phospholipase A1 activity	IEA
GO:0008970	Function	Phospholipase A1 activity	TAS
GO:0009395	Process	Phospholipid catabolic process	IEA
GO:0010314	Function	Phosphatidylinositol-5-phosphate binding	ISS
GO:0016020	Component	Membrane	IEA
GO:0016042	Process	Lipid catabolic process	IEA
GO:0016410	Function	N-acyltransferase activity	IDA	29447909
GO:0016740	Function	Transferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0031901	Component	Early endosome membrane	IEA
GO:0031901	Component	Early endosome membrane	ISS
GO:0032266	Function	Phosphatidylinositol-3-phosphate binding	ISS
GO:0036149	Process	Phosphatidylinositol acyl-chain remodeling	TAS
GO:0043325	Function	Phosphatidylinositol-3,4-bisphosphate binding	ISS
GO:0046475	Process	Glycerophospholipid catabolic process	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0047498	Function	Calcium-dependent phospholipase A2 activity	IBA
GO:0070273	Function	Phosphatidylinositol-4-phosphate binding	ISS
GO:0070292	Process	N-acylphosphatidylethanolamine metabolic process	IDA	29447909
GO:0080025	Function	Phosphatidylinositol-3,5-bisphosphate binding	ISS
GO:2001137	Process	Positive regulation of endocytic recycling	IMP	24413173

MIM	HGNC	e!Ensembl
620649	24791	ENSG00000188089

Q3MJ16

Protein name

Cytosolic phospholipase A2 epsilon (cPLA2-epsilon) (EC 3.1.1.4) (Calcium-dependent N-acyltransferase) (Phospholipase A2 group IVE)

Protein function

Calcium-dependent N-acyltransferase involved in the biosynthesis of N-acyl ethanolamines (NAEs) in the brain (PubMed:29447909). Transfers the sn-1 fatty acyl chain of phosphatidylcholine (fatty acyl donor) to the amine group of phosphatidylethan

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00168	C2	68 → 172	C2 domain	Domain
PF01735	PLA2_B	374 → 633	Lysophospholipase catalytic domain	Family
PF18695	cPLA2_C2	209 → 323	Cytosolic phospholipases A2 C2-domain	Domain

Sequence

MSLQASEGCPGLGTNVFVPQSPQTDEEGSRSGRSFSEFEDTQDLDTPGLPPFCPMAPWGS
EEGLSPCHLLTVRVIRMKNVRQADMLSQTDCFVSLWLPTASQKKLRTRTISNCPNPEWNE
SFNFQIQSRVKNVLELSVCDEDTVTPDDHLLTVLYDLTKLCFRKKTHVKFPLNPQGMEEL
EVEFLLEESPSPPETLVTNGVLVSRQVSCLEVHAQSRRRRKREKMKDLLVMVNESFENTQ
RVRPCLEPCCPTSACFQTAACFHYPKYFQSQVHVEVPKSHWSCGLCCRSRKKGPISQPLD
CLSDGQVMTLPVGESYELHMKSTPCPETLDVRLGFSLCPAELEFLQKRKVVVAKALKQVL
QLEEDLQEDEVPLIAIMATGGGTRSMTSMYGHLLGLQKLNLLDCASYITGLSGATWTMAT
LYRDPDWSSKNLEPAIFEARRHVVKDKLPSLFPDQLRKFQEELRQRSQEGYRVTFTDFWG
LLIETCLGDERNECKLSDQRAALSCGQNPLPIYLTINVKDDVSNQDFREWFEFSPYEVGL
QKYGAFIPSELFGSEFFMGRLVKRIPESRICYMLGLWSSIFSLNLLDAWNLSHTSEEFFH
RWTREKVQDIEDEPILPEIPKCDANILETTVVIPGSWLSNSFREILTHRSFVSEFHNFLS
GLQLHTNYLQNGQFSRWKDTVLDGFPNQLTESANHLCLLDTAFFVNSSYPPLLRPERKAD
LIIHLNYCAGSQTKPLKQTCEYCTVQNIPFPKYELPDENENLKECYLMENPQEPDAPIVT
FFPLINDTFRKYKAPGVERSPEELEQGQVDIYGPKTPYATKELTYTEATFDKLVKLSEYN
ILNNKDTLLQALRLAVEKKKRLKGQCPS

Sequence length

868

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Glycerophospholipid metabolism	Acyl chain remodelling of PC
Ether lipid metabolism	Acyl chain remodelling of PS
Arachidonic acid metabolism	Acyl chain remodelling of PE
Linoleic acid metabolism	Acyl chain remodelling of PI
alpha-Linolenic acid metabolism	Hydrolysis of LPC
Metabolic pathways
MAPK signaling pathway
Ras signaling pathway
Phospholipase D signaling pathway
Necroptosis
Vascular smooth muscle contraction
VEGF signaling pathway
Platelet activation
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Glutamatergic synapse
Serotonergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
GnRH signaling pathway
Ovarian steroidogenesis
Oxytocin signaling pathway
Choline metabolism in cancer

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Abnormality of neuronal migration	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	34712369, 35880180	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Panic Disorder	Panic Disorder	BEFREE	29391400		★★★★★ ★☆☆☆☆ Found in Text Mining only
Panic Disorder	Panic disorder	Pubtator	29391400	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	31423851	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	35880180	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
PLA2G4F	[]	27	["Glycerophospholipid metabolism","Ether lipid metabolism","Arachidonic acid metabolism","Linoleic acid metabolism","alpha-Linolenic acid metabolism","MAPK signaling pathway","Ras signaling pathway","Phospholipase D signaling pathway","Necroptosis","Vascular smooth muscle contraction","VEGF signaling pathway","Platelet activation"]	[]
PLA2G4D	[]	27	["Glycerophospholipid metabolism","Ether lipid metabolism","Arachidonic acid metabolism","Linoleic acid metabolism","alpha-Linolenic acid metabolism","MAPK signaling pathway","Ras signaling pathway","Phospholipase D signaling pathway","Necroptosis","Vascular smooth muscle contraction","VEGF signaling pathway","Platelet activation"]	[]
PLA2G4C	[]	26	["Glycerophospholipid metabolism","Ether lipid metabolism","Arachidonic acid metabolism","Linoleic acid metabolism","alpha-Linolenic acid metabolism","MAPK signaling pathway","Ras signaling pathway","Phospholipase D signaling pathway","Necroptosis","Vascular smooth muscle contraction","VEGF signaling pathway","Platelet activation"]	[]
PLA2G4B	[]	26	["Glycerophospholipid metabolism","Ether lipid metabolism","Arachidonic acid metabolism","Linoleic acid metabolism","alpha-Linolenic acid metabolism","MAPK signaling pathway","Ras signaling pathway","Phospholipase D signaling pathway","Necroptosis","Vascular smooth muscle contraction","VEGF signaling pathway","Platelet activation"]	[]
JMJD7-PLA2G4B	[]	26	["Glycerophospholipid metabolism","Ether lipid metabolism","Arachidonic acid metabolism","Linoleic acid metabolism","alpha-Linolenic acid metabolism","MAPK signaling pathway","Ras signaling pathway","Phospholipase D signaling pathway","Necroptosis","Vascular smooth muscle contraction","VEGF signaling pathway","Platelet activation"]	[]

PLA2G4E (phospholipase A2 group IVE)

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