PLA2G4D (phospholipase A2 group IVD)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 283748
• Gene name: Phospholipase A2 group IVD
• Gene symbol: PLA2G4D
• Synonyms (NCBI Gene): cPLA2delta
• Chromosome: 15
• Chromosome location: 15q15.1
• Summary: The phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids (Chiba et al., 2004 [PubMed 14709560]).[supplied by OMIM, Jun 2009]

miRNA Show/Hide all (91)

miRTarBase ID	miRNA	Experiments	Reference
MIRT531215	hsa-miR-5683	PAR-CLIP	22012620
MIRT531214	hsa-miR-383-5p	PAR-CLIP	22012620
MIRT531213	hsa-miR-154-5p	PAR-CLIP	22012620
MIRT531212	hsa-miR-1288-5p	PAR-CLIP	22012620
MIRT531211	hsa-miR-5690	PAR-CLIP	22012620
MIRT531210	hsa-miR-1199-5p	PAR-CLIP	22012620
MIRT531209	hsa-miR-6751-3p	PAR-CLIP	22012620
MIRT531208	hsa-miR-1225-3p	PAR-CLIP	22012620
MIRT531207	hsa-miR-1233-3p	PAR-CLIP	22012620
MIRT531206	hsa-miR-4772-5p	PAR-CLIP	22012620
MIRT531205	hsa-miR-548v	PAR-CLIP	22012620
MIRT531204	hsa-miR-4663	PAR-CLIP	22012620
MIRT531203	hsa-miR-4474-3p	PAR-CLIP	22012620
MIRT531202	hsa-miR-186-5p	PAR-CLIP	22012620
MIRT531201	hsa-miR-3606-3p	PAR-CLIP	22012620
MIRT531200	hsa-miR-513a-3p	PAR-CLIP	22012620
MIRT531199	hsa-miR-513c-3p	PAR-CLIP	22012620
MIRT531198	hsa-miR-6507-5p	PAR-CLIP	22012620
MIRT531197	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT531196	hsa-miR-651-5p	PAR-CLIP	22012620
MIRT531210	hsa-miR-1199-5p	PAR-CLIP	26701625
MIRT531208	hsa-miR-1225-3p	PAR-CLIP	26701625
MIRT531207	hsa-miR-1233-3p	PAR-CLIP	26701625
MIRT531212	hsa-miR-1288-5p	PAR-CLIP	26701625
MIRT531213	hsa-miR-154-5p	PAR-CLIP	26701625
MIRT531214	hsa-miR-383-5p	PAR-CLIP	26701625
MIRT531204	hsa-miR-4663	PAR-CLIP	26701625
MIRT531206	hsa-miR-4772-5p	PAR-CLIP	26701625
MIRT531215	hsa-miR-5683	PAR-CLIP	26701625
MIRT531209	hsa-miR-6751-3p	PAR-CLIP	26701625
MIRT531215	hsa-miR-5683	PAR-CLIP	22012620
MIRT531214	hsa-miR-383-5p	PAR-CLIP	22012620
MIRT531213	hsa-miR-154-5p	PAR-CLIP	22012620
MIRT531212	hsa-miR-1288-5p	PAR-CLIP	22012620
MIRT531211	hsa-miR-5690	PAR-CLIP	22012620
MIRT531210	hsa-miR-1199-5p	PAR-CLIP	22012620
MIRT531209	hsa-miR-6751-3p	PAR-CLIP	22012620
MIRT531208	hsa-miR-1225-3p	PAR-CLIP	22012620
MIRT531207	hsa-miR-1233-3p	PAR-CLIP	22012620
MIRT531206	hsa-miR-4772-5p	PAR-CLIP	22012620
MIRT531205	hsa-miR-548v	PAR-CLIP	22012620
MIRT531204	hsa-miR-4663	PAR-CLIP	22012620
MIRT531203	hsa-miR-4474-3p	PAR-CLIP	22012620
MIRT531202	hsa-miR-186-5p	PAR-CLIP	22012620
MIRT531201	hsa-miR-3606-3p	PAR-CLIP	22012620
MIRT531200	hsa-miR-513a-3p	PAR-CLIP	22012620
MIRT531199	hsa-miR-513c-3p	PAR-CLIP	22012620
MIRT531198	hsa-miR-6507-5p	PAR-CLIP	22012620
MIRT531197	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT531196	hsa-miR-651-5p	PAR-CLIP	22012620
MIRT1238718	hsa-miR-1206	CLIP-seq
MIRT1238719	hsa-miR-3150b-3p	CLIP-seq
MIRT1238720	hsa-miR-3185	CLIP-seq
MIRT1238721	hsa-miR-3612	CLIP-seq
MIRT1238722	hsa-miR-4289	CLIP-seq
MIRT1238723	hsa-miR-4689	CLIP-seq
MIRT1238724	hsa-miR-4695-5p	CLIP-seq
MIRT1238725	hsa-miR-4784	CLIP-seq
MIRT1238726	hsa-miR-650	CLIP-seq
MIRT1238727	hsa-miR-767-3p	CLIP-seq
MIRT1238719	hsa-miR-3150b-3p	CLIP-seq
MIRT1238720	hsa-miR-3185	CLIP-seq
MIRT1238721	hsa-miR-3612	CLIP-seq
MIRT1238723	hsa-miR-4689	CLIP-seq
MIRT1238724	hsa-miR-4695-5p	CLIP-seq
MIRT1238725	hsa-miR-4784	CLIP-seq
MIRT1238726	hsa-miR-650	CLIP-seq
MIRT2070249	hsa-miR-759	CLIP-seq
MIRT1238719	hsa-miR-3150b-3p	CLIP-seq
MIRT1238720	hsa-miR-3185	CLIP-seq
MIRT1238721	hsa-miR-3612	CLIP-seq
MIRT2297520	hsa-miR-4434	CLIP-seq
MIRT2297521	hsa-miR-4459	CLIP-seq
MIRT2297522	hsa-miR-4516	CLIP-seq
MIRT1238723	hsa-miR-4689	CLIP-seq
MIRT1238724	hsa-miR-4695-5p	CLIP-seq
MIRT2297523	hsa-miR-4722-5p	CLIP-seq
MIRT1238725	hsa-miR-4784	CLIP-seq
MIRT2297524	hsa-miR-583	CLIP-seq
MIRT1238726	hsa-miR-650	CLIP-seq
MIRT1238718	hsa-miR-1206	CLIP-seq
MIRT1238722	hsa-miR-4289	CLIP-seq
MIRT1238727	hsa-miR-767-3p	CLIP-seq
MIRT2439514	hsa-miR-3160-5p	CLIP-seq
MIRT2439515	hsa-miR-3655	CLIP-seq
MIRT2439516	hsa-miR-578	CLIP-seq
MIRT2070249	hsa-miR-759	CLIP-seq
MIRT2439514	hsa-miR-3160-5p	CLIP-seq
MIRT2439515	hsa-miR-3655	CLIP-seq
MIRT2439516	hsa-miR-578	CLIP-seq
MIRT2070249	hsa-miR-759	CLIP-seq

Gene ontology (GO) Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004620	Function	Phospholipase activity	IEA
GO:0004623	Function	Phospholipase A2 activity	IEA
GO:0005509	Function	Calcium ion binding	IBA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006650	Process	Glycerophospholipid metabolic process	IEA
GO:0008970	Function	Phospholipase A1 activity	IEA
GO:0008970	Function	Phospholipase A1 activity	TAS
GO:0009395	Process	Phospholipid catabolic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016042	Process	Lipid catabolic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0036148	Process	Phosphatidylglycerol acyl-chain remodeling	TAS
GO:0036149	Process	Phosphatidylinositol acyl-chain remodeling	TAS
GO:0046475	Process	Glycerophospholipid catabolic process	IBA
GO:0046475	Process	Glycerophospholipid catabolic process	IDA	14709560
GO:0046872	Function	Metal ion binding	IEA
GO:0047498	Function	Calcium-dependent phospholipase A2 activity	IBA
GO:0047498	Function	Calcium-dependent phospholipase A2 activity	IDA	14709560

Other IDs

• MIM: 612864
• HGNC: 30038
• e!Ensembl: ENSG00000159337

Protein

• UniProt ID: Q86XP0
• Protein name: Cytosolic phospholipase A2 delta (cPLA2-delta) (EC 3.1.1.4) (Phospholipase A2 group IVD)
• Protein function: Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position (PubMed:14709560). Has a preference for linoleic acid at the sn-2 position (PubMed:14709560).
• PDB: 5IXC , 5IZ5 , 5IZR
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00168	C2	22 → 126	C2 domain	Domain
  PF01735	PLA2_B	323 → 563	Lysophospholipase catalytic domain	Family
  PF18695	cPLA2_C2	163 → 270	Cytosolic phospholipases A2 C2-domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues (PubMed:14709560). Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in
• Sequence:

  MESLSPGGPPGHPYQGEASTCWQLTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFK
  TKTLTDTSHPVWNEAFRFLIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLL
  RKTFSQSPQGEEELDVEFLMEETSDRPENLITNKVIVARELSCLDVHLDSTGSTAVVADQ
  DKLELELVLKGSYEDTQTSFLGTASAFRFHYMAALETELSGRLRSSRSNGWNGDNSAGYL
  TVPLRPLTIGKEVTMDVPAPNAPGVRLQLKAEGCPEELAVHLGFNLCAEEQAFLSRRKQV
  VAKALKQALQLDRDLQEDEVPVVGIMATGGGARAMTSLYGHLLALQKLGLLDCVTYFSGI
  SGSTWTMAHLYGDPEWSQRDLEGPIRYAREHLAKSKLEVFSPERLASYRRELELRAEQGH
  PTTFVDLWALVLESMLHGQVMDQKLSGQRAALERGQNPLPLYLSLNVKENNLETLDFKEW
  VEFSPYEVGFLKYGAFVPPELFGSEFFMGRLMRRIPEPRICFLEAIWSNIFSLNLLDAWY
  DLTSSGESWKQHIKDKTRSLEKEPLTTSGTSSRLEASWLQPGTALAQAFKGFLTGRPLHQ
  RSPNFLQGLQLHQDYCSHKDFSTWADYQLDSMPSQLTPKEPRLCLVDAAYFINTSSPSMF
  RPGRRLDLILSFDYSLSAPFEALQQTELYCRARGLPFPRVEPSPQDQHQPRECHLFSDPA
  CPEAPILLHFPLVNASFKDHSAPGVQRSPAELQGGQVDLTGATCPYTLSNMTYKEEDFER
  LLRLSDYNVQTSQGAILQALRTALKHRTLEARPPRAQT

• Sequence length: 818

Pathways

KEGG Pathway	Reactome Pathway
Glycerophospholipid metabolism	Acyl chain remodelling of PC
Ether lipid metabolism	Acyl chain remodelling of PS
Arachidonic acid metabolism	Acyl chain remodelling of PE
Linoleic acid metabolism	Acyl chain remodelling of PI
alpha-Linolenic acid metabolism	Acyl chain remodelling of PG
Metabolic pathways	Hydrolysis of LPC
MAPK signaling pathway	Synthesis of PA
Ras signaling pathway
Phospholipase D signaling pathway
Necroptosis
Vascular smooth muscle contraction
VEGF signaling pathway
Platelet activation
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Glutamatergic synapse
Serotonergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
GnRH signaling pathway
Ovarian steroidogenesis
Oxytocin signaling pathway
Choline metabolism in cancer

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Cervical cancer	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Dermatitis Allergic Contact	Allergic contact dermatitis	Pubtator	35028126	Stimulate	★☆☆☆☆ Found in Text Mining only
Dermatitis, Atopic	Dermatitis	BEFREE	14709560		★☆☆☆☆ Found in Text Mining only
Eczema	Eczema	BEFREE	14709560		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31606962		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	16213696		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

PLA2G4F 28 shared pathwaysGlycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, Linoleic acid metabolism, alpha-Linolenic acid metabolism, MAPK signaling pathway, Ras signaling pathway, Phospholipase D signaling pathway, Necroptosis, Vascular smooth muscle contraction, VEGF signaling pathway, Platelet activation +16 more Related via 28 shared pathways including Glycerophospholipid metabolism, Ether lipid metabolism. PLA2G4B 28 shared pathwaysGlycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, Linoleic acid metabolism, alpha-Linolenic acid metabolism, MAPK signaling pathway, Ras signaling pathway, Phospholipase D signaling pathway, Necroptosis, Vascular smooth muscle contraction, VEGF signaling pathway, Platelet activation +16 more Related via 28 shared pathways including Glycerophospholipid metabolism, Ether lipid metabolism. JMJD7-PLA2G4B 28 shared pathwaysGlycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, Linoleic acid metabolism, alpha-Linolenic acid metabolism, MAPK signaling pathway, Ras signaling pathway, Phospholipase D signaling pathway, Necroptosis, Vascular smooth muscle contraction, VEGF signaling pathway, Platelet activation +16 more Related via 28 shared pathways including Glycerophospholipid metabolism, Ether lipid metabolism. PLA2G4E 27 shared pathwaysGlycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, Linoleic acid metabolism, alpha-Linolenic acid metabolism, MAPK signaling pathway, Ras signaling pathway, Phospholipase D signaling pathway, Necroptosis, Vascular smooth muscle contraction, VEGF signaling pathway, Platelet activation +15 more Related via 27 shared pathways including Glycerophospholipid metabolism, Ether lipid metabolism. PLA2G4C 26 shared pathwaysGlycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, Linoleic acid metabolism, alpha-Linolenic acid metabolism, MAPK signaling pathway, Ras signaling pathway, Phospholipase D signaling pathway, Necroptosis, Vascular smooth muscle contraction, VEGF signaling pathway, Platelet activation +14 more Related via 26 shared pathways including Glycerophospholipid metabolism, Ether lipid metabolism.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
PLA2G4F	0	[]	28	["Glycerophospholipid metabolism","Ether lipid metabolism","Arachidonic acid metabolism","Linoleic acid metabolism","alpha-Linolenic acid metabolism","MAPK signaling pathway","Ras signaling pathway","Phospholipase D signaling pathway","Necroptosis","Vascular smooth muscle contraction","VEGF signaling pathway","Platelet activation"]	0	[]
PLA2G4B	0	[]	28	["Glycerophospholipid metabolism","Ether lipid metabolism","Arachidonic acid metabolism","Linoleic acid metabolism","alpha-Linolenic acid metabolism","MAPK signaling pathway","Ras signaling pathway","Phospholipase D signaling pathway","Necroptosis","Vascular smooth muscle contraction","VEGF signaling pathway","Platelet activation"]	0	[]
JMJD7-PLA2G4B	0	[]	28	["Glycerophospholipid metabolism","Ether lipid metabolism","Arachidonic acid metabolism","Linoleic acid metabolism","alpha-Linolenic acid metabolism","MAPK signaling pathway","Ras signaling pathway","Phospholipase D signaling pathway","Necroptosis","Vascular smooth muscle contraction","VEGF signaling pathway","Platelet activation"]	0	[]
PLA2G4E	0	[]	27	["Glycerophospholipid metabolism","Ether lipid metabolism","Arachidonic acid metabolism","Linoleic acid metabolism","alpha-Linolenic acid metabolism","MAPK signaling pathway","Ras signaling pathway","Phospholipase D signaling pathway","Necroptosis","Vascular smooth muscle contraction","VEGF signaling pathway","Platelet activation"]	0	[]
PLA2G4C	0	[]	26	["Glycerophospholipid metabolism","Ether lipid metabolism","Arachidonic acid metabolism","Linoleic acid metabolism","alpha-Linolenic acid metabolism","MAPK signaling pathway","Ras signaling pathway","Phospholipase D signaling pathway","Necroptosis","Vascular smooth muscle contraction","VEGF signaling pathway","Platelet activation"]	0	[]

Diseases Linked via Similar Genes

Neurodevelopmental disorder Linked via 2 of 5 related genesPLA2G4B, JMJD7-PLA2G4B Schizophrenia Linked via 2 of 5 related genesPLA2G4B, PLA2G4C Chagas cardiomyopathy Linked via 1 of 5 related genesPLA2G4F

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Neurodevelopmental disorder	2	["PLA2G4B","JMJD7-PLA2G4B"]
Schizophrenia	2	["PLA2G4B","PLA2G4C"]
Chagas cardiomyopathy	1	["PLA2G4F"]