Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	10552
Gene name	Actin related protein 2/3 complex subunit 1A
Gene symbol	ARPC1A
Synonyms (NCBI Gene)	Arc40HEL-68HEL-S-307SOP2HsSOP2L
Chromosome	7
Chromosome location	7q22.1
Summary	This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they bo

152 Show/Hide all (152)

miRTarBase ID	miRNA	Experiments	Reference
MIRT046551	hsa-let-7i-5p	CLASH	23622248
MIRT038032	hsa-miR-423-5p	CLASH	23622248
MIRT799641	hsa-miR-1	CLIP-seq
MIRT799642	hsa-miR-1256	CLIP-seq
MIRT799643	hsa-miR-1276	CLIP-seq
MIRT799644	hsa-miR-133a	CLIP-seq
MIRT799645	hsa-miR-133b	CLIP-seq
MIRT799646	hsa-miR-181a	CLIP-seq
MIRT799647	hsa-miR-181b	CLIP-seq
MIRT799648	hsa-miR-181c	CLIP-seq
MIRT799649	hsa-miR-181d	CLIP-seq
MIRT799650	hsa-miR-190	CLIP-seq
MIRT799651	hsa-miR-190b	CLIP-seq
MIRT799652	hsa-miR-206	CLIP-seq
MIRT799653	hsa-miR-3138	CLIP-seq
MIRT799654	hsa-miR-3591-5p	CLIP-seq
MIRT799655	hsa-miR-3613-3p	CLIP-seq
MIRT799656	hsa-miR-3673	CLIP-seq
MIRT799657	hsa-miR-3681	CLIP-seq
MIRT799658	hsa-miR-3689a-5p	CLIP-seq
MIRT799659	hsa-miR-3689b	CLIP-seq
MIRT799660	hsa-miR-3689e	CLIP-seq
MIRT799661	hsa-miR-3689f	CLIP-seq
MIRT799662	hsa-miR-4262	CLIP-seq
MIRT799663	hsa-miR-4272	CLIP-seq
MIRT799664	hsa-miR-4276	CLIP-seq
MIRT799665	hsa-miR-4277	CLIP-seq
MIRT799666	hsa-miR-4302	CLIP-seq
MIRT799667	hsa-miR-4311	CLIP-seq
MIRT799668	hsa-miR-4504	CLIP-seq
MIRT799669	hsa-miR-4775	CLIP-seq
MIRT799670	hsa-miR-495	CLIP-seq
MIRT799671	hsa-miR-542-3p	CLIP-seq
MIRT799672	hsa-miR-548aa	CLIP-seq
MIRT799673	hsa-miR-548ac	CLIP-seq
MIRT799674	hsa-miR-548d-3p	CLIP-seq
MIRT799675	hsa-miR-548z	CLIP-seq
MIRT799676	hsa-miR-583	CLIP-seq
MIRT799677	hsa-miR-587	CLIP-seq
MIRT799678	hsa-miR-590-3p	CLIP-seq
MIRT799679	hsa-miR-606	CLIP-seq
MIRT799680	hsa-miR-613	CLIP-seq
MIRT799681	hsa-miR-648	CLIP-seq
MIRT799682	hsa-miR-9	CLIP-seq
MIRT799683	hsa-miR-10a	CLIP-seq
MIRT799684	hsa-miR-10b	CLIP-seq
MIRT799646	hsa-miR-181a	CLIP-seq
MIRT799647	hsa-miR-181b	CLIP-seq
MIRT799648	hsa-miR-181c	CLIP-seq
MIRT799649	hsa-miR-181d	CLIP-seq
MIRT799685	hsa-miR-197	CLIP-seq
MIRT799653	hsa-miR-3138	CLIP-seq
MIRT799686	hsa-miR-339-5p	CLIP-seq
MIRT799687	hsa-miR-3620	CLIP-seq
MIRT799657	hsa-miR-3681	CLIP-seq
MIRT799662	hsa-miR-4262	CLIP-seq
MIRT799663	hsa-miR-4272	CLIP-seq
MIRT799665	hsa-miR-4277	CLIP-seq
MIRT799688	hsa-miR-4287	CLIP-seq
MIRT799689	hsa-miR-4421	CLIP-seq
MIRT799690	hsa-miR-4469	CLIP-seq
MIRT799691	hsa-miR-4685-3p	CLIP-seq
MIRT799669	hsa-miR-4775	CLIP-seq
MIRT799692	hsa-miR-5096	CLIP-seq
MIRT799672	hsa-miR-548aa	CLIP-seq
MIRT799678	hsa-miR-590-3p	CLIP-seq
MIRT799641	hsa-miR-1	CLIP-seq
MIRT799642	hsa-miR-1256	CLIP-seq
MIRT799643	hsa-miR-1276	CLIP-seq
MIRT799644	hsa-miR-133a	CLIP-seq
MIRT799645	hsa-miR-133b	CLIP-seq
MIRT799646	hsa-miR-181a	CLIP-seq
MIRT799647	hsa-miR-181b	CLIP-seq
MIRT799648	hsa-miR-181c	CLIP-seq
MIRT799649	hsa-miR-181d	CLIP-seq
MIRT799650	hsa-miR-190	CLIP-seq
MIRT799651	hsa-miR-190b	CLIP-seq
MIRT799685	hsa-miR-197	CLIP-seq
MIRT799652	hsa-miR-206	CLIP-seq
MIRT799653	hsa-miR-3138	CLIP-seq
MIRT799656	hsa-miR-3673	CLIP-seq
MIRT799657	hsa-miR-3681	CLIP-seq
MIRT799658	hsa-miR-3689a-5p	CLIP-seq
MIRT799659	hsa-miR-3689b	CLIP-seq
MIRT799660	hsa-miR-3689e	CLIP-seq
MIRT799661	hsa-miR-3689f	CLIP-seq
MIRT799662	hsa-miR-4262	CLIP-seq
MIRT799663	hsa-miR-4272	CLIP-seq
MIRT799664	hsa-miR-4276	CLIP-seq
MIRT799665	hsa-miR-4277	CLIP-seq
MIRT799688	hsa-miR-4287	CLIP-seq
MIRT799667	hsa-miR-4311	CLIP-seq
MIRT799690	hsa-miR-4469	CLIP-seq
MIRT799691	hsa-miR-4685-3p	CLIP-seq
MIRT799669	hsa-miR-4775	CLIP-seq
MIRT799692	hsa-miR-5096	CLIP-seq
MIRT799672	hsa-miR-548aa	CLIP-seq
MIRT799676	hsa-miR-583	CLIP-seq
MIRT799678	hsa-miR-590-3p	CLIP-seq
MIRT799679	hsa-miR-606	CLIP-seq
MIRT799680	hsa-miR-613	CLIP-seq
MIRT799682	hsa-miR-9	CLIP-seq
MIRT2176097	hsa-miR-1227	CLIP-seq
MIRT2176098	hsa-miR-1238	CLIP-seq
MIRT799653	hsa-miR-3138	CLIP-seq
MIRT799657	hsa-miR-3681	CLIP-seq
MIRT2176099	hsa-miR-4260	CLIP-seq
MIRT799663	hsa-miR-4272	CLIP-seq
MIRT2176100	hsa-miR-4283	CLIP-seq
MIRT2176101	hsa-miR-4489	CLIP-seq
MIRT2176102	hsa-miR-4492	CLIP-seq
MIRT2176103	hsa-miR-4498	CLIP-seq
MIRT799669	hsa-miR-4775	CLIP-seq
MIRT2176104	hsa-miR-516a-3p	CLIP-seq
MIRT799672	hsa-miR-548aa	CLIP-seq
MIRT799678	hsa-miR-590-3p	CLIP-seq
MIRT2176105	hsa-miR-762	CLIP-seq
MIRT2479463	hsa-miR-1193	CLIP-seq
MIRT2176097	hsa-miR-1227	CLIP-seq
MIRT2176098	hsa-miR-1238	CLIP-seq
MIRT799642	hsa-miR-1256	CLIP-seq
MIRT2479464	hsa-miR-1287	CLIP-seq
MIRT799650	hsa-miR-190	CLIP-seq
MIRT799651	hsa-miR-190b	CLIP-seq
MIRT2479465	hsa-miR-2467-5p	CLIP-seq
MIRT2479466	hsa-miR-3135b	CLIP-seq
MIRT2479467	hsa-miR-3189-3p	CLIP-seq
MIRT799658	hsa-miR-3689a-5p	CLIP-seq
MIRT799659	hsa-miR-3689b	CLIP-seq
MIRT799660	hsa-miR-3689e	CLIP-seq
MIRT799661	hsa-miR-3689f	CLIP-seq
MIRT2176099	hsa-miR-4260	CLIP-seq
MIRT799664	hsa-miR-4276	CLIP-seq
MIRT2176100	hsa-miR-4283	CLIP-seq
MIRT2479468	hsa-miR-4284	CLIP-seq
MIRT799666	hsa-miR-4302	CLIP-seq
MIRT2176101	hsa-miR-4489	CLIP-seq
MIRT2176102	hsa-miR-4492	CLIP-seq
MIRT2176103	hsa-miR-4498	CLIP-seq
MIRT2479469	hsa-miR-4730	CLIP-seq
MIRT2479470	hsa-miR-502-5p	CLIP-seq
MIRT2479471	hsa-miR-512-5p	CLIP-seq
MIRT2176104	hsa-miR-516a-3p	CLIP-seq
MIRT2479472	hsa-miR-658	CLIP-seq
MIRT2176105	hsa-miR-762	CLIP-seq
MIRT2479463	hsa-miR-1193	CLIP-seq
MIRT2479464	hsa-miR-1287	CLIP-seq
MIRT2479465	hsa-miR-2467-5p	CLIP-seq
MIRT2479466	hsa-miR-3135b	CLIP-seq
MIRT2479468	hsa-miR-4284	CLIP-seq
MIRT2479469	hsa-miR-4730	CLIP-seq
MIRT2479472	hsa-miR-658	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0003779	Function	Actin binding	TAS	8978670
GO:0005515	Function	Protein binding	IPI	35512704
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005885	Component	Arp2/3 protein complex	IBA
GO:0005885	Component	Arp2/3 protein complex	IEA
GO:0005885	Component	Arp2/3 protein complex	ISS
GO:0015629	Component	Actin cytoskeleton	IEA
GO:0015629	Component	Actin cytoskeleton	TAS	8978670
GO:0030036	Process	Actin cytoskeleton organization	TAS	8978670
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IBA
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IEA
GO:0035861	Component	Site of double-strand break	ISS
GO:0036195	Component	Muscle cell projection membrane	IEA
GO:0045202	Component	Synapse	IEA
GO:0051015	Function	Actin filament binding	IBA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0098978	Component	Glutamatergic synapse	IEA

MIM	HGNC	e!Ensembl
604220	703	ENSG00000241685

Q92747

Protein name

Actin-related protein 2/3 complex subunit 1A (SOP2-like protein)

Protein function

Probably functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. {ECO:0000305|Pub

PDB

6YW7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00400	WD40	42 → 80	WD domain, G-beta repeat	Repeat
PF00400	WD40	132 → 170	WD domain, G-beta repeat	Repeat

Sequence

MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDW
APKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLI
SVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKP
ASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVS
TLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDIPKQSIQRNMSAM
ERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTL
ESSIQGLRIM

Sequence length

370

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Endocytosis	Regulation of actin dynamics for phagocytic cup formation
Tight junction	EPHB-mediated forward signaling
Fc gamma R-mediated phagocytosis	RHO GTPases Activate WASPs and WAVEs
Regulation of actin cytoskeleton	Clathrin-mediated endocytosis
Bacterial invasion of epithelial cells	FCGR3A-mediated phagocytosis
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Yersinia infection

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
ARPC5	[]	14	["Endocytosis","Tight junction","Fc gamma R-mediated phagocytosis","Regulation of actin cytoskeleton","Bacterial invasion of epithelial cells","Pathogenic Escherichia coli infection","Shigellosis","Salmonella infection","Yersinia infection","Regulation of actin dynamics for phagocytic cup formation","RHO GTPases Activate WASPs and WAVEs","FCGR3A-mediated phagocytosis"]	[]
ARPC4	[]	14	["Endocytosis","Tight junction","Fc gamma R-mediated phagocytosis","Regulation of actin cytoskeleton","Bacterial invasion of epithelial cells","Pathogenic Escherichia coli infection","Shigellosis","Salmonella infection","Yersinia infection","Regulation of actin dynamics for phagocytic cup formation","RHO GTPases Activate WASPs and WAVEs","FCGR3A-mediated phagocytosis"]	[]
ARPC3	[]	14	["Endocytosis","Tight junction","Fc gamma R-mediated phagocytosis","Regulation of actin cytoskeleton","Bacterial invasion of epithelial cells","Pathogenic Escherichia coli infection","Shigellosis","Salmonella infection","Yersinia infection","Regulation of actin dynamics for phagocytic cup formation","RHO GTPases Activate WASPs and WAVEs","FCGR3A-mediated phagocytosis"]	[]
ACTR3	[]	14	["Endocytosis","Tight junction","Fc gamma R-mediated phagocytosis","Regulation of actin cytoskeleton","Bacterial invasion of epithelial cells","Pathogenic Escherichia coli infection","Shigellosis","Salmonella infection","Yersinia infection","Regulation of actin dynamics for phagocytic cup formation","RHO GTPases Activate WASPs and WAVEs","FCGR3A-mediated phagocytosis"]	[]
ACTR2	[]	14	["Endocytosis","Tight junction","Fc gamma R-mediated phagocytosis","Regulation of actin cytoskeleton","Bacterial invasion of epithelial cells","Pathogenic Escherichia coli infection","Shigellosis","Salmonella infection","Yersinia infection","Regulation of actin dynamics for phagocytic cup formation","RHO GTPases Activate WASPs and WAVEs","FCGR3A-mediated phagocytosis"]	[]

ARPC1A (actin related protein 2/3 complex subunit 1A)

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