Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	10093
Gene name	Actin related protein 2/3 complex subunit 4
Gene symbol	ARPC4
Synonyms (NCBI Gene)	ARC20DEVLOP20-ARC
Chromosome	3
Chromosome location	3p25.3
Summary	This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nuclea

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miRTarBase ID	miRNA	Experiments	Reference
MIRT721438	hsa-miR-216b-5p	HITS-CLIP	19536157
MIRT721437	hsa-miR-3675-3p	HITS-CLIP	19536157
MIRT721436	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT721435	hsa-miR-3924	HITS-CLIP	19536157
MIRT721434	hsa-miR-106a-3p	HITS-CLIP	19536157
MIRT618272	hsa-miR-8485	HITS-CLIP	23824327
MIRT618271	hsa-miR-3684	HITS-CLIP	23824327
MIRT618270	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618269	hsa-miR-4764-3p	HITS-CLIP	23824327
MIRT721438	hsa-miR-216b-5p	HITS-CLIP	19536157
MIRT721437	hsa-miR-3675-3p	HITS-CLIP	19536157
MIRT721436	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT721435	hsa-miR-3924	HITS-CLIP	19536157
MIRT721434	hsa-miR-106a-3p	HITS-CLIP	19536157
MIRT618272	hsa-miR-8485	HITS-CLIP	23824327
MIRT618271	hsa-miR-3684	HITS-CLIP	23824327
MIRT618270	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618269	hsa-miR-4764-3p	HITS-CLIP	23824327
MIRT799777	hsa-miR-101	CLIP-seq
MIRT799778	hsa-miR-144	CLIP-seq
MIRT799779	hsa-miR-1915	CLIP-seq
MIRT799780	hsa-miR-3199	CLIP-seq
MIRT799781	hsa-miR-4652-5p	CLIP-seq
MIRT799782	hsa-miR-4724-5p	CLIP-seq
MIRT799783	hsa-miR-4740-5p	CLIP-seq
MIRT799784	hsa-miR-4797-5p	CLIP-seq
MIRT799785	hsa-miR-582-5p	CLIP-seq
MIRT799777	hsa-miR-101	CLIP-seq
MIRT799786	hsa-miR-1291	CLIP-seq
MIRT799787	hsa-miR-1321	CLIP-seq
MIRT799778	hsa-miR-144	CLIP-seq
MIRT799788	hsa-miR-1538	CLIP-seq
MIRT799789	hsa-miR-1825	CLIP-seq
MIRT799790	hsa-miR-3128	CLIP-seq
MIRT799791	hsa-miR-3132	CLIP-seq
MIRT799792	hsa-miR-3184	CLIP-seq
MIRT799793	hsa-miR-3194-5p	CLIP-seq
MIRT799794	hsa-miR-320e	CLIP-seq
MIRT799795	hsa-miR-323-5p	CLIP-seq
MIRT799796	hsa-miR-328	CLIP-seq
MIRT799797	hsa-miR-3622a-5p	CLIP-seq
MIRT799798	hsa-miR-3677-3p	CLIP-seq
MIRT799799	hsa-miR-3689d	CLIP-seq
MIRT799800	hsa-miR-423-5p	CLIP-seq
MIRT799801	hsa-miR-4252	CLIP-seq
MIRT799802	hsa-miR-4269	CLIP-seq
MIRT799803	hsa-miR-4271	CLIP-seq
MIRT799804	hsa-miR-4278	CLIP-seq
MIRT799805	hsa-miR-4293	CLIP-seq
MIRT799806	hsa-miR-4419a	CLIP-seq
MIRT799807	hsa-miR-4456	CLIP-seq
MIRT799808	hsa-miR-4459	CLIP-seq
MIRT799809	hsa-miR-4493	CLIP-seq
MIRT799810	hsa-miR-4510	CLIP-seq
MIRT799811	hsa-miR-4514	CLIP-seq
MIRT799812	hsa-miR-4645-5p	CLIP-seq
MIRT799813	hsa-miR-4646-3p	CLIP-seq
MIRT799814	hsa-miR-4649-3p	CLIP-seq
MIRT799815	hsa-miR-4661-3p	CLIP-seq
MIRT799816	hsa-miR-4673	CLIP-seq
MIRT799817	hsa-miR-4691-3p	CLIP-seq
MIRT799818	hsa-miR-4692	CLIP-seq
MIRT799819	hsa-miR-4716-3p	CLIP-seq
MIRT799820	hsa-miR-4717-5p	CLIP-seq
MIRT799821	hsa-miR-4720-5p	CLIP-seq
MIRT799822	hsa-miR-4722-5p	CLIP-seq
MIRT799823	hsa-miR-4725-3p	CLIP-seq
MIRT799824	hsa-miR-4728-5p	CLIP-seq
MIRT799825	hsa-miR-4739	CLIP-seq
MIRT799826	hsa-miR-4745-3p	CLIP-seq
MIRT799827	hsa-miR-4747-5p	CLIP-seq
MIRT799828	hsa-miR-4753-5p	CLIP-seq
MIRT799829	hsa-miR-4756-5p	CLIP-seq
MIRT799830	hsa-miR-4773	CLIP-seq
MIRT799831	hsa-miR-4779	CLIP-seq
MIRT799832	hsa-miR-4786-3p	CLIP-seq
MIRT799784	hsa-miR-4797-5p	CLIP-seq
MIRT799833	hsa-miR-4799-3p	CLIP-seq
MIRT799834	hsa-miR-498	CLIP-seq
MIRT799835	hsa-miR-512-3p	CLIP-seq
MIRT799836	hsa-miR-548c-3p	CLIP-seq
MIRT799785	hsa-miR-582-5p	CLIP-seq
MIRT799837	hsa-miR-625	CLIP-seq
MIRT799838	hsa-miR-765	CLIP-seq
MIRT799839	hsa-miR-876-3p	CLIP-seq
MIRT799840	hsa-miR-940	CLIP-seq
MIRT799777	hsa-miR-101	CLIP-seq
MIRT799841	hsa-miR-1237	CLIP-seq
MIRT799778	hsa-miR-144	CLIP-seq
MIRT799842	hsa-miR-149	CLIP-seq
MIRT799779	hsa-miR-1915	CLIP-seq
MIRT799843	hsa-miR-296-5p	CLIP-seq
MIRT799844	hsa-miR-3064-5p	CLIP-seq
MIRT799845	hsa-miR-3119	CLIP-seq
MIRT799846	hsa-miR-3120-3p	CLIP-seq
MIRT799847	hsa-miR-3137	CLIP-seq
MIRT799848	hsa-miR-3140-3p	CLIP-seq
MIRT799780	hsa-miR-3199	CLIP-seq
MIRT799849	hsa-miR-4257	CLIP-seq
MIRT799850	hsa-miR-4449	CLIP-seq
MIRT799812	hsa-miR-4645-5p	CLIP-seq
MIRT799781	hsa-miR-4652-5p	CLIP-seq
MIRT799816	hsa-miR-4673	CLIP-seq
MIRT799851	hsa-miR-4676-5p	CLIP-seq
MIRT799852	hsa-miR-4707-3p	CLIP-seq
MIRT799853	hsa-miR-4726-3p	CLIP-seq
MIRT799783	hsa-miR-4740-5p	CLIP-seq
MIRT799854	hsa-miR-4747-3p	CLIP-seq
MIRT799855	hsa-miR-4749-3p	CLIP-seq
MIRT799856	hsa-miR-4794	CLIP-seq
MIRT799784	hsa-miR-4797-5p	CLIP-seq
MIRT799834	hsa-miR-498	CLIP-seq
MIRT799836	hsa-miR-548c-3p	CLIP-seq
MIRT799857	hsa-miR-575	CLIP-seq
MIRT799785	hsa-miR-582-5p	CLIP-seq
MIRT799777	hsa-miR-101	CLIP-seq
MIRT799841	hsa-miR-1237	CLIP-seq
MIRT799778	hsa-miR-144	CLIP-seq
MIRT799842	hsa-miR-149	CLIP-seq
MIRT799843	hsa-miR-296-5p	CLIP-seq
MIRT799844	hsa-miR-3064-5p	CLIP-seq
MIRT799845	hsa-miR-3119	CLIP-seq
MIRT799847	hsa-miR-3137	CLIP-seq
MIRT799848	hsa-miR-3140-3p	CLIP-seq
MIRT1936270	hsa-miR-34b	CLIP-seq
MIRT799798	hsa-miR-3677-3p	CLIP-seq
MIRT799799	hsa-miR-3689d	CLIP-seq
MIRT799801	hsa-miR-4252	CLIP-seq
MIRT799849	hsa-miR-4257	CLIP-seq
MIRT799802	hsa-miR-4269	CLIP-seq
MIRT799812	hsa-miR-4645-5p	CLIP-seq
MIRT799816	hsa-miR-4673	CLIP-seq
MIRT799851	hsa-miR-4676-5p	CLIP-seq
MIRT799817	hsa-miR-4691-3p	CLIP-seq
MIRT1936271	hsa-miR-4704-3p	CLIP-seq
MIRT799853	hsa-miR-4726-3p	CLIP-seq
MIRT799855	hsa-miR-4749-3p	CLIP-seq
MIRT799856	hsa-miR-4794	CLIP-seq
MIRT799784	hsa-miR-4797-5p	CLIP-seq
MIRT1936272	hsa-miR-508-5p	CLIP-seq
MIRT799857	hsa-miR-575	CLIP-seq
MIRT799785	hsa-miR-582-5p	CLIP-seq
MIRT1936273	hsa-miR-665	CLIP-seq
MIRT799812	hsa-miR-4645-5p	CLIP-seq
MIRT799816	hsa-miR-4673	CLIP-seq
MIRT799847	hsa-miR-3137	CLIP-seq
MIRT2176114	hsa-miR-3160-5p	CLIP-seq
MIRT2176115	hsa-miR-3192	CLIP-seq
MIRT1936270	hsa-miR-34b	CLIP-seq
MIRT2176116	hsa-miR-3616-3p	CLIP-seq
MIRT2176117	hsa-miR-3649	CLIP-seq
MIRT2176118	hsa-miR-3689a-3p	CLIP-seq
MIRT2176119	hsa-miR-3689c	CLIP-seq
MIRT799799	hsa-miR-3689d	CLIP-seq
MIRT799801	hsa-miR-4252	CLIP-seq
MIRT799849	hsa-miR-4257	CLIP-seq
MIRT2176120	hsa-miR-4260	CLIP-seq
MIRT2176121	hsa-miR-451b	CLIP-seq
MIRT799812	hsa-miR-4645-5p	CLIP-seq
MIRT799816	hsa-miR-4673	CLIP-seq
MIRT799851	hsa-miR-4676-5p	CLIP-seq
MIRT799817	hsa-miR-4691-3p	CLIP-seq
MIRT1936271	hsa-miR-4704-3p	CLIP-seq
MIRT799824	hsa-miR-4728-5p	CLIP-seq
MIRT2176122	hsa-miR-4736	CLIP-seq
MIRT799855	hsa-miR-4749-3p	CLIP-seq
MIRT2176123	hsa-miR-486-3p	CLIP-seq
MIRT799857	hsa-miR-575	CLIP-seq
MIRT2176124	hsa-miR-578	CLIP-seq
MIRT2176125	hsa-miR-621	CLIP-seq
MIRT799777	hsa-miR-101	CLIP-seq
MIRT799778	hsa-miR-144	CLIP-seq
MIRT799847	hsa-miR-3137	CLIP-seq
MIRT799795	hsa-miR-323-5p	CLIP-seq
MIRT799849	hsa-miR-4257	CLIP-seq
MIRT799807	hsa-miR-4456	CLIP-seq
MIRT799851	hsa-miR-4676-5p	CLIP-seq
MIRT799857	hsa-miR-575	CLIP-seq
MIRT799785	hsa-miR-582-5p	CLIP-seq
MIRT799839	hsa-miR-876-3p	CLIP-seq
MIRT799799	hsa-miR-3689d	CLIP-seq
MIRT799855	hsa-miR-4749-3p	CLIP-seq
MIRT2479480	hsa-miR-1224-3p	CLIP-seq
MIRT799841	hsa-miR-1237	CLIP-seq
MIRT2479481	hsa-miR-1289	CLIP-seq
MIRT799786	hsa-miR-1291	CLIP-seq
MIRT2479482	hsa-miR-1470	CLIP-seq
MIRT799842	hsa-miR-149	CLIP-seq
MIRT799789	hsa-miR-1825	CLIP-seq
MIRT2479483	hsa-miR-185	CLIP-seq
MIRT2479484	hsa-miR-2682	CLIP-seq
MIRT799843	hsa-miR-296-5p	CLIP-seq
MIRT799844	hsa-miR-3064-5p	CLIP-seq
MIRT799845	hsa-miR-3119	CLIP-seq
MIRT799846	hsa-miR-3120-3p	CLIP-seq
MIRT799791	hsa-miR-3132	CLIP-seq
MIRT799847	hsa-miR-3137	CLIP-seq
MIRT799848	hsa-miR-3140-3p	CLIP-seq
MIRT2479485	hsa-miR-3173-3p	CLIP-seq
MIRT799792	hsa-miR-3184	CLIP-seq
MIRT2479486	hsa-miR-3188	CLIP-seq
MIRT2176115	hsa-miR-3192	CLIP-seq
MIRT2479487	hsa-miR-3198	CLIP-seq
MIRT799795	hsa-miR-323-5p	CLIP-seq
MIRT799796	hsa-miR-328	CLIP-seq
MIRT2479488	hsa-miR-342-5p	CLIP-seq
MIRT1936270	hsa-miR-34b	CLIP-seq
MIRT2176116	hsa-miR-3616-3p	CLIP-seq
MIRT2176117	hsa-miR-3649	CLIP-seq
MIRT799798	hsa-miR-3677-3p	CLIP-seq
MIRT2176118	hsa-miR-3689a-3p	CLIP-seq
MIRT2176119	hsa-miR-3689c	CLIP-seq
MIRT799799	hsa-miR-3689d	CLIP-seq
MIRT799800	hsa-miR-423-5p	CLIP-seq
MIRT799801	hsa-miR-4252	CLIP-seq
MIRT799849	hsa-miR-4257	CLIP-seq
MIRT799803	hsa-miR-4271	CLIP-seq
MIRT2479489	hsa-miR-4286	CLIP-seq
MIRT2479490	hsa-miR-4294	CLIP-seq
MIRT2479491	hsa-miR-4306	CLIP-seq
MIRT2479492	hsa-miR-4309	CLIP-seq
MIRT2479493	hsa-miR-4423-3p	CLIP-seq
MIRT799807	hsa-miR-4456	CLIP-seq
MIRT2479494	hsa-miR-4469	CLIP-seq
MIRT799809	hsa-miR-4493	CLIP-seq
MIRT2479495	hsa-miR-449c	CLIP-seq
MIRT2479496	hsa-miR-4529-5p	CLIP-seq
MIRT2479497	hsa-miR-4644	CLIP-seq
MIRT799812	hsa-miR-4645-5p	CLIP-seq
MIRT799813	hsa-miR-4646-3p	CLIP-seq
MIRT799814	hsa-miR-4649-3p	CLIP-seq
MIRT2479498	hsa-miR-4651	CLIP-seq
MIRT2479499	hsa-miR-4664-5p	CLIP-seq
MIRT2479500	hsa-miR-4667-3p	CLIP-seq
MIRT799816	hsa-miR-4673	CLIP-seq
MIRT799851	hsa-miR-4676-5p	CLIP-seq
MIRT2479501	hsa-miR-4695-5p	CLIP-seq
MIRT1936271	hsa-miR-4704-3p	CLIP-seq
MIRT799852	hsa-miR-4707-3p	CLIP-seq
MIRT799819	hsa-miR-4716-3p	CLIP-seq
MIRT799820	hsa-miR-4717-5p	CLIP-seq
MIRT799823	hsa-miR-4725-3p	CLIP-seq
MIRT799853	hsa-miR-4726-3p	CLIP-seq
MIRT799824	hsa-miR-4728-5p	CLIP-seq
MIRT2479502	hsa-miR-4731-5p	CLIP-seq
MIRT2479503	hsa-miR-4738-3p	CLIP-seq
MIRT799854	hsa-miR-4747-3p	CLIP-seq
MIRT799827	hsa-miR-4747-5p	CLIP-seq
MIRT799855	hsa-miR-4749-3p	CLIP-seq
MIRT799828	hsa-miR-4753-5p	CLIP-seq
MIRT2479504	hsa-miR-4766-5p	CLIP-seq
MIRT799856	hsa-miR-4794	CLIP-seq
MIRT1936272	hsa-miR-508-5p	CLIP-seq
MIRT799835	hsa-miR-512-3p	CLIP-seq
MIRT799857	hsa-miR-575	CLIP-seq
MIRT2479505	hsa-miR-608	CLIP-seq
MIRT799837	hsa-miR-625	CLIP-seq
MIRT2479506	hsa-miR-637	CLIP-seq
MIRT1936273	hsa-miR-665	CLIP-seq
MIRT799839	hsa-miR-876-3p	CLIP-seq
MIRT799840	hsa-miR-940	CLIP-seq
MIRT2479480	hsa-miR-1224-3p	CLIP-seq
MIRT799841	hsa-miR-1237	CLIP-seq
MIRT2479481	hsa-miR-1289	CLIP-seq
MIRT799786	hsa-miR-1291	CLIP-seq
MIRT2479482	hsa-miR-1470	CLIP-seq
MIRT799842	hsa-miR-149	CLIP-seq
MIRT799789	hsa-miR-1825	CLIP-seq
MIRT2479483	hsa-miR-185	CLIP-seq
MIRT2479484	hsa-miR-2682	CLIP-seq
MIRT799843	hsa-miR-296-5p	CLIP-seq
MIRT799844	hsa-miR-3064-5p	CLIP-seq
MIRT799845	hsa-miR-3119	CLIP-seq
MIRT799846	hsa-miR-3120-3p	CLIP-seq
MIRT799791	hsa-miR-3132	CLIP-seq
MIRT799847	hsa-miR-3137	CLIP-seq
MIRT799848	hsa-miR-3140-3p	CLIP-seq
MIRT2479485	hsa-miR-3173-3p	CLIP-seq
MIRT799792	hsa-miR-3184	CLIP-seq
MIRT2479486	hsa-miR-3188	CLIP-seq
MIRT2176115	hsa-miR-3192	CLIP-seq
MIRT2479487	hsa-miR-3198	CLIP-seq
MIRT799795	hsa-miR-323-5p	CLIP-seq
MIRT799796	hsa-miR-328	CLIP-seq
MIRT2479488	hsa-miR-342-5p	CLIP-seq
MIRT1936270	hsa-miR-34b	CLIP-seq
MIRT2176116	hsa-miR-3616-3p	CLIP-seq
MIRT2176117	hsa-miR-3649	CLIP-seq
MIRT2675405	hsa-miR-3664-3p	CLIP-seq
MIRT799798	hsa-miR-3677-3p	CLIP-seq
MIRT2176118	hsa-miR-3689a-3p	CLIP-seq
MIRT2176119	hsa-miR-3689c	CLIP-seq
MIRT799799	hsa-miR-3689d	CLIP-seq
MIRT799800	hsa-miR-423-5p	CLIP-seq
MIRT799801	hsa-miR-4252	CLIP-seq
MIRT799849	hsa-miR-4257	CLIP-seq
MIRT799803	hsa-miR-4271	CLIP-seq
MIRT2479489	hsa-miR-4286	CLIP-seq
MIRT2479490	hsa-miR-4294	CLIP-seq
MIRT2479491	hsa-miR-4306	CLIP-seq
MIRT2479492	hsa-miR-4309	CLIP-seq
MIRT2479493	hsa-miR-4423-3p	CLIP-seq
MIRT799807	hsa-miR-4456	CLIP-seq
MIRT2479494	hsa-miR-4469	CLIP-seq
MIRT799809	hsa-miR-4493	CLIP-seq
MIRT2479495	hsa-miR-449c	CLIP-seq
MIRT2479496	hsa-miR-4529-5p	CLIP-seq
MIRT2479497	hsa-miR-4644	CLIP-seq
MIRT799812	hsa-miR-4645-5p	CLIP-seq
MIRT799813	hsa-miR-4646-3p	CLIP-seq
MIRT799814	hsa-miR-4649-3p	CLIP-seq
MIRT2479498	hsa-miR-4651	CLIP-seq
MIRT2479499	hsa-miR-4664-5p	CLIP-seq
MIRT2479500	hsa-miR-4667-3p	CLIP-seq
MIRT799816	hsa-miR-4673	CLIP-seq
MIRT799851	hsa-miR-4676-5p	CLIP-seq
MIRT2479501	hsa-miR-4695-5p	CLIP-seq
MIRT1936271	hsa-miR-4704-3p	CLIP-seq
MIRT799852	hsa-miR-4707-3p	CLIP-seq
MIRT799819	hsa-miR-4716-3p	CLIP-seq
MIRT799820	hsa-miR-4717-5p	CLIP-seq
MIRT799823	hsa-miR-4725-3p	CLIP-seq
MIRT799853	hsa-miR-4726-3p	CLIP-seq
MIRT799824	hsa-miR-4728-5p	CLIP-seq
MIRT2479502	hsa-miR-4731-5p	CLIP-seq
MIRT2479503	hsa-miR-4738-3p	CLIP-seq
MIRT799854	hsa-miR-4747-3p	CLIP-seq
MIRT799827	hsa-miR-4747-5p	CLIP-seq
MIRT799855	hsa-miR-4749-3p	CLIP-seq
MIRT799828	hsa-miR-4753-5p	CLIP-seq
MIRT2479504	hsa-miR-4766-5p	CLIP-seq
MIRT799856	hsa-miR-4794	CLIP-seq
MIRT1936272	hsa-miR-508-5p	CLIP-seq
MIRT2675406	hsa-miR-510	CLIP-seq
MIRT799835	hsa-miR-512-3p	CLIP-seq
MIRT799857	hsa-miR-575	CLIP-seq
MIRT2479505	hsa-miR-608	CLIP-seq
MIRT799837	hsa-miR-625	CLIP-seq
MIRT2479506	hsa-miR-637	CLIP-seq
MIRT1936273	hsa-miR-665	CLIP-seq
MIRT2675407	hsa-miR-873	CLIP-seq
MIRT799839	hsa-miR-876-3p	CLIP-seq
MIRT799840	hsa-miR-940	CLIP-seq

25 Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0005200	Function	Structural constituent of cytoskeleton	IDA	11741539
GO:0005515	Function	Protein binding	IPI	11162547, 16169070, 24981860, 25416956, 26655834, 30021884, 31515488, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005885	Component	Arp2/3 protein complex	IBA
GO:0005885	Component	Arp2/3 protein complex	IDA	11162547, 11741539
GO:0005885	Component	Arp2/3 protein complex	IEA
GO:0005885	Component	Arp2/3 protein complex	TAS	9230079
GO:0015629	Component	Actin cytoskeleton	IEA
GO:0019899	Function	Enzyme binding	IPI	23921388
GO:0030041	Process	Actin filament polymerization	IEA
GO:0030674	Function	Protein-macromolecule adaptor activity	IPI	11162547
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IBA
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IDA	11741539
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IEA
GO:0035861	Component	Site of double-strand break	ISS
GO:0042995	Component	Cell projection	IEA
GO:0045010	Process	Actin nucleation	NAS	11162547
GO:0051015	Function	Actin filament binding	IDA	11741539
GO:0051015	Function	Actin filament binding	NAS	11162547
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337

MIM	HGNC	e!Ensembl
604226	707	ENSG00000241553

P59998

Protein name

Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC)

Protein function

Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks

PDB

6UHC , 6YW6 , 6YW7 , 8P94

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05856	ARPC4	1 → 167	ARP2/3 complex 20 kDa subunit (ARPC4)	Family

Sequence

MTATLRPYLSAVRATLQAALCLENFSSQVVERHNKPEVEVRSSKELLLQPVTISRNEKEK
VLIEGSINSVRVSIAVKQADEIEKILCHKFMRFMMMRAENFFILRRKPVEGYDISFLITN
FHTEQMYKHKLVDFVIHFMEEIDKEISEMKLSVNARARIVAEEFLKNF

Sequence length

168

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Endocytosis	Regulation of actin dynamics for phagocytic cup formation
Tight junction	EPHB-mediated forward signaling
Fc gamma R-mediated phagocytosis	RHO GTPases Activate WASPs and WAVEs
Regulation of actin cytoskeleton	Clathrin-mediated endocytosis
Bacterial invasion of epithelial cells	FCGR3A-mediated phagocytosis
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Yersinia infection

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	39998322	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Developmental delay, language impairment, and ocular abnormalities	Conflicting classifications of pathogenicity	ClinVar ClinVar, Disgenet, GWAS catalog, HPO ClinVar, Disgenet, GWAS catalog, HPO ClinVar, Disgenet, GWAS catalog, HPO	35047857	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
ARPC5	[]	14	["Endocytosis","Tight junction","Fc gamma R-mediated phagocytosis","Regulation of actin cytoskeleton","Bacterial invasion of epithelial cells","Pathogenic Escherichia coli infection","Shigellosis","Salmonella infection","Yersinia infection","Regulation of actin dynamics for phagocytic cup formation","RHO GTPases Activate WASPs and WAVEs","FCGR3A-mediated phagocytosis"]	[]
ARPC3	[]	14	["Endocytosis","Tight junction","Fc gamma R-mediated phagocytosis","Regulation of actin cytoskeleton","Bacterial invasion of epithelial cells","Pathogenic Escherichia coli infection","Shigellosis","Salmonella infection","Yersinia infection","Regulation of actin dynamics for phagocytic cup formation","RHO GTPases Activate WASPs and WAVEs","FCGR3A-mediated phagocytosis"]	[]
ACTR3	[]	14	["Endocytosis","Tight junction","Fc gamma R-mediated phagocytosis","Regulation of actin cytoskeleton","Bacterial invasion of epithelial cells","Pathogenic Escherichia coli infection","Shigellosis","Salmonella infection","Yersinia infection","Regulation of actin dynamics for phagocytic cup formation","RHO GTPases Activate WASPs and WAVEs","FCGR3A-mediated phagocytosis"]	[]
ACTR2	[]	14	["Endocytosis","Tight junction","Fc gamma R-mediated phagocytosis","Regulation of actin cytoskeleton","Bacterial invasion of epithelial cells","Pathogenic Escherichia coli infection","Shigellosis","Salmonella infection","Yersinia infection","Regulation of actin dynamics for phagocytic cup formation","RHO GTPases Activate WASPs and WAVEs","FCGR3A-mediated phagocytosis"]	[]
ARPC2	[]	14	["Endocytosis","Tight junction","Fc gamma R-mediated phagocytosis","Regulation of actin cytoskeleton","Bacterial invasion of epithelial cells","Pathogenic Escherichia coli infection","Shigellosis","Salmonella infection","Yersinia infection","Regulation of actin dynamics for phagocytic cup formation","RHO GTPases Activate WASPs and WAVEs","FCGR3A-mediated phagocytosis"]	[]

ARPC4 (actin related protein 2/3 complex subunit 4)

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