ARPC2 (actin related protein 2/3 complex subunit 2)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 10109
• Gene name: Actin related protein 2/3 complex subunit 2
• Gene symbol: ARPC2
• Synonyms (NCBI Gene): ARC34, PNAS-139, PRO2446, p34-Arc
• Chromosome: 2
• Chromosome location: 2q35
• Summary: This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by

miRNA Show/Hide all (263)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050988	hsa-miR-17-5p	CLASH	23622248
MIRT050616	hsa-miR-20a-5p	CLASH	23622248
MIRT049237	hsa-miR-92a-3p	CLASH	23622248
MIRT048830	hsa-miR-93-5p	CLASH	23622248
MIRT045659	hsa-miR-149-5p	CLASH	23622248
MIRT045659	hsa-miR-149-5p	CLASH	23622248
MIRT719035	hsa-miR-590-3p	HITS-CLIP	19536157
MIRT719030	hsa-miR-411-5p	HITS-CLIP	19536157
MIRT719034	hsa-miR-6872-3p	HITS-CLIP	19536157
MIRT719032	hsa-miR-4735-5p	HITS-CLIP	19536157
MIRT719033	hsa-miR-6832-5p	HITS-CLIP	19536157
MIRT719031	hsa-miR-4775	HITS-CLIP	19536157
MIRT719030	hsa-miR-411-5p	HITS-CLIP	19536157
MIRT669477	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT669476	hsa-miR-764	HITS-CLIP	23824327
MIRT669475	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT677413	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT677412	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT677411	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT677410	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT677409	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT677408	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678598	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT669474	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT669473	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678597	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT678596	hsa-miR-6131	HITS-CLIP	23824327
MIRT677407	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT669470	hsa-miR-640	HITS-CLIP	23824327
MIRT678595	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT678594	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT669477	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT669476	hsa-miR-764	HITS-CLIP	23824327
MIRT669475	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT677413	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT677412	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT677411	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT677410	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT677409	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT677408	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT669474	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT669473	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT677407	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT669470	hsa-miR-640	HITS-CLIP	23824327
MIRT669469	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT669477	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT669476	hsa-miR-764	HITS-CLIP	23824327
MIRT669475	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT669474	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT669473	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT669472	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT669471	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT669470	hsa-miR-640	HITS-CLIP	23824327
MIRT669469	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT660505	hsa-miR-3194-5p	HITS-CLIP	23824327
MIRT660504	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT660503	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT660502	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT660501	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT660500	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT660499	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT660498	hsa-miR-1202	HITS-CLIP	23824327
MIRT660497	hsa-miR-3972	HITS-CLIP	23824327
MIRT660496	hsa-miR-5006-5p	HITS-CLIP	23824327
MIRT719035	hsa-miR-590-3p	HITS-CLIP	19536157
MIRT719030	hsa-miR-411-5p	HITS-CLIP	19536157
MIRT719034	hsa-miR-6872-3p	HITS-CLIP	19536157
MIRT719032	hsa-miR-4735-5p	HITS-CLIP	19536157
MIRT719033	hsa-miR-6832-5p	HITS-CLIP	19536157
MIRT719031	hsa-miR-4775	HITS-CLIP	19536157
MIRT719030	hsa-miR-411-5p	HITS-CLIP	19536157
MIRT669477	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT669476	hsa-miR-764	HITS-CLIP	23824327
MIRT669475	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT677413	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT677412	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT677411	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT677410	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT677409	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT677408	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678598	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT669474	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT669473	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678597	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT678596	hsa-miR-6131	HITS-CLIP	23824327
MIRT677407	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT669470	hsa-miR-640	HITS-CLIP	23824327
MIRT678595	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT678594	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT669477	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT669476	hsa-miR-764	HITS-CLIP	23824327
MIRT669475	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT677413	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT677412	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT677411	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT677410	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT677409	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT677408	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT669474	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT669473	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT677407	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT669470	hsa-miR-640	HITS-CLIP	23824327
MIRT669469	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT669477	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT669476	hsa-miR-764	HITS-CLIP	23824327
MIRT669475	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT669474	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT669473	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT669472	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT669471	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT669470	hsa-miR-640	HITS-CLIP	23824327
MIRT669469	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT660505	hsa-miR-3194-5p	HITS-CLIP	23824327
MIRT660504	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT660503	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT660502	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT660501	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT660500	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT660499	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT660498	hsa-miR-1202	HITS-CLIP	23824327
MIRT660497	hsa-miR-3972	HITS-CLIP	23824327
MIRT660496	hsa-miR-5006-5p	HITS-CLIP	23824327
MIRT799717	hsa-miR-1184	CLIP-seq
MIRT799718	hsa-miR-1205	CLIP-seq
MIRT799719	hsa-miR-1264	CLIP-seq
MIRT799720	hsa-miR-1292	CLIP-seq
MIRT799721	hsa-miR-2052	CLIP-seq
MIRT799722	hsa-miR-217	CLIP-seq
MIRT799723	hsa-miR-25	CLIP-seq
MIRT799724	hsa-miR-3158-5p	CLIP-seq
MIRT799725	hsa-miR-32	CLIP-seq
MIRT799726	hsa-miR-3545-3p	CLIP-seq
MIRT799727	hsa-miR-363	CLIP-seq
MIRT799728	hsa-miR-367	CLIP-seq
MIRT799729	hsa-miR-3671	CLIP-seq
MIRT799730	hsa-miR-4266	CLIP-seq
MIRT799731	hsa-miR-4433	CLIP-seq
MIRT799732	hsa-miR-4453	CLIP-seq
MIRT799733	hsa-miR-4471	CLIP-seq
MIRT799734	hsa-miR-450b-5p	CLIP-seq
MIRT799735	hsa-miR-4538	CLIP-seq
MIRT799736	hsa-miR-4680-5p	CLIP-seq
MIRT799737	hsa-miR-4700-3p	CLIP-seq
MIRT799738	hsa-miR-4760-5p	CLIP-seq
MIRT799739	hsa-miR-4772-3p	CLIP-seq
MIRT799740	hsa-miR-518a-5p	CLIP-seq
MIRT799741	hsa-miR-527	CLIP-seq
MIRT799742	hsa-miR-544	CLIP-seq
MIRT799743	hsa-miR-570	CLIP-seq
MIRT799744	hsa-miR-635	CLIP-seq
MIRT799745	hsa-miR-888	CLIP-seq
MIRT799746	hsa-miR-891b	CLIP-seq
MIRT799747	hsa-miR-92a	CLIP-seq
MIRT799748	hsa-miR-92b	CLIP-seq
MIRT799723	hsa-miR-25	CLIP-seq
MIRT799749	hsa-miR-3148	CLIP-seq
MIRT799725	hsa-miR-32	CLIP-seq
MIRT799727	hsa-miR-363	CLIP-seq
MIRT799728	hsa-miR-367	CLIP-seq
MIRT799750	hsa-miR-3978	CLIP-seq
MIRT799732	hsa-miR-4453	CLIP-seq
MIRT799751	hsa-miR-4477a	CLIP-seq
MIRT799735	hsa-miR-4538	CLIP-seq
MIRT799738	hsa-miR-4760-5p	CLIP-seq
MIRT799739	hsa-miR-4772-3p	CLIP-seq
MIRT799740	hsa-miR-518a-5p	CLIP-seq
MIRT799741	hsa-miR-527	CLIP-seq
MIRT799752	hsa-miR-583	CLIP-seq
MIRT799746	hsa-miR-891b	CLIP-seq
MIRT799747	hsa-miR-92a	CLIP-seq
MIRT799748	hsa-miR-92b	CLIP-seq
MIRT799719	hsa-miR-1264	CLIP-seq
MIRT799717	hsa-miR-1184	CLIP-seq
MIRT799718	hsa-miR-1205	CLIP-seq
MIRT799719	hsa-miR-1264	CLIP-seq
MIRT1936255	hsa-miR-188-5p	CLIP-seq
MIRT799721	hsa-miR-2052	CLIP-seq
MIRT799723	hsa-miR-25	CLIP-seq
MIRT799749	hsa-miR-3148	CLIP-seq
MIRT799724	hsa-miR-3158-5p	CLIP-seq
MIRT1936256	hsa-miR-3177-5p	CLIP-seq
MIRT799725	hsa-miR-32	CLIP-seq
MIRT799726	hsa-miR-3545-3p	CLIP-seq
MIRT799727	hsa-miR-363	CLIP-seq
MIRT1936257	hsa-miR-3653	CLIP-seq
MIRT1936258	hsa-miR-3658	CLIP-seq
MIRT799728	hsa-miR-367	CLIP-seq
MIRT799729	hsa-miR-3671	CLIP-seq
MIRT799750	hsa-miR-3978	CLIP-seq
MIRT799730	hsa-miR-4266	CLIP-seq
MIRT799731	hsa-miR-4433	CLIP-seq
MIRT799732	hsa-miR-4453	CLIP-seq
MIRT799734	hsa-miR-450b-5p	CLIP-seq
MIRT1936259	hsa-miR-4511	CLIP-seq
MIRT799735	hsa-miR-4538	CLIP-seq
MIRT799736	hsa-miR-4680-5p	CLIP-seq
MIRT1936260	hsa-miR-4694-3p	CLIP-seq
MIRT1936261	hsa-miR-4698	CLIP-seq
MIRT799738	hsa-miR-4760-5p	CLIP-seq
MIRT799739	hsa-miR-4772-3p	CLIP-seq
MIRT799740	hsa-miR-518a-5p	CLIP-seq
MIRT799741	hsa-miR-527	CLIP-seq
MIRT799742	hsa-miR-544	CLIP-seq
MIRT1936262	hsa-miR-548b-3p	CLIP-seq
MIRT799743	hsa-miR-570	CLIP-seq
MIRT799752	hsa-miR-583	CLIP-seq
MIRT799745	hsa-miR-888	CLIP-seq
MIRT799746	hsa-miR-891b	CLIP-seq
MIRT799747	hsa-miR-92a	CLIP-seq
MIRT799748	hsa-miR-92b	CLIP-seq
MIRT799723	hsa-miR-25	CLIP-seq
MIRT799725	hsa-miR-32	CLIP-seq
MIRT799727	hsa-miR-363	CLIP-seq
MIRT799728	hsa-miR-367	CLIP-seq
MIRT799739	hsa-miR-4772-3p	CLIP-seq
MIRT799740	hsa-miR-518a-5p	CLIP-seq
MIRT799741	hsa-miR-527	CLIP-seq
MIRT799746	hsa-miR-891b	CLIP-seq
MIRT799747	hsa-miR-92a	CLIP-seq
MIRT799748	hsa-miR-92b	CLIP-seq
MIRT1936255	hsa-miR-188-5p	CLIP-seq
MIRT1936257	hsa-miR-3653	CLIP-seq
MIRT1936258	hsa-miR-3658	CLIP-seq
MIRT1936259	hsa-miR-4511	CLIP-seq
MIRT2444021	hsa-miR-4709-3p	CLIP-seq
MIRT1936262	hsa-miR-548b-3p	CLIP-seq
MIRT799721	hsa-miR-2052	CLIP-seq
MIRT799722	hsa-miR-217	CLIP-seq
MIRT799723	hsa-miR-25	CLIP-seq
MIRT799725	hsa-miR-32	CLIP-seq
MIRT799726	hsa-miR-3545-3p	CLIP-seq
MIRT799727	hsa-miR-363	CLIP-seq
MIRT799728	hsa-miR-367	CLIP-seq
MIRT799729	hsa-miR-3671	CLIP-seq
MIRT799750	hsa-miR-3978	CLIP-seq
MIRT799730	hsa-miR-4266	CLIP-seq
MIRT799731	hsa-miR-4433	CLIP-seq
MIRT799732	hsa-miR-4453	CLIP-seq
MIRT799735	hsa-miR-4538	CLIP-seq
MIRT799736	hsa-miR-4680-5p	CLIP-seq
MIRT799737	hsa-miR-4700-3p	CLIP-seq
MIRT799738	hsa-miR-4760-5p	CLIP-seq
MIRT799739	hsa-miR-4772-3p	CLIP-seq
MIRT799740	hsa-miR-518a-5p	CLIP-seq
MIRT799741	hsa-miR-527	CLIP-seq
MIRT799743	hsa-miR-570	CLIP-seq
MIRT799745	hsa-miR-888	CLIP-seq
MIRT799746	hsa-miR-891b	CLIP-seq
MIRT799747	hsa-miR-92a	CLIP-seq
MIRT799748	hsa-miR-92b	CLIP-seq
MIRT799721	hsa-miR-2052	CLIP-seq
MIRT799722	hsa-miR-217	CLIP-seq
MIRT799726	hsa-miR-3545-3p	CLIP-seq
MIRT799729	hsa-miR-3671	CLIP-seq
MIRT799730	hsa-miR-4266	CLIP-seq
MIRT799731	hsa-miR-4433	CLIP-seq
MIRT799736	hsa-miR-4680-5p	CLIP-seq
MIRT799737	hsa-miR-4700-3p	CLIP-seq
MIRT799738	hsa-miR-4760-5p	CLIP-seq
MIRT799739	hsa-miR-4772-3p	CLIP-seq
MIRT799743	hsa-miR-570	CLIP-seq
MIRT799745	hsa-miR-888	CLIP-seq
MIRT799746	hsa-miR-891b	CLIP-seq

Gene ontology (GO) Show/Hide all (45)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0005200	Function	Structural constituent of cytoskeleton	IBA
GO:0005200	Function	Structural constituent of cytoskeleton	IDA	11741539
GO:0005200	Function	Structural constituent of cytoskeleton	TAS	9230079
GO:0005515	Function	Protein binding	IPI	11162547, 12473693, 16027158, 17350576, 24132237, 32911434
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005885	Component	Arp2/3 protein complex	IBA
GO:0005885	Component	Arp2/3 protein complex	IDA	11741539
GO:0005885	Component	Arp2/3 protein complex	IEA
GO:0005885	Component	Arp2/3 protein complex	TAS	9230079
GO:0005886	Component	Plasma membrane	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0005925	Component	Focal adhesion	IEA
GO:0010592	Process	Positive regulation of lamellipodium assembly	IMP	18560548
GO:0015629	Component	Actin cytoskeleton	IEA
GO:0015629	Component	Actin cytoskeleton	TAS	9230079
GO:0030027	Component	Lamellipodium	IDA	9230079
GO:0030041	Process	Actin filament polymerization	IEA
GO:0030672	Component	Synaptic vesicle membrane	IEA
GO:0030838	Process	Positive regulation of actin filament polymerization	IEA
GO:0031252	Component	Cell leading edge	IEA
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IBA
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IDA	11741539
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IEA
GO:0035861	Component	Site of double-strand break	ISS
GO:0036195	Component	Muscle cell projection membrane	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0044089	Process	Positive regulation of cellular component biogenesis	IEA
GO:0045202	Component	Synapse	IEA
GO:0045202	Component	Synapse	IEA
GO:0051015	Function	Actin filament binding	IDA	11741539
GO:0051130	Process	Positive regulation of cellular component organization	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0070358	Process	Actin polymerization-dependent cell motility	TAS	9230079
GO:0098793	Component	Presynapse	IEA
GO:0098794	Component	Postsynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:1900026	Process	Positive regulation of substrate adhesion-dependent cell spreading	IEA

Other IDs

• MIM: 604224
• HGNC: 705
• e!Ensembl: ENSG00000163466

Protein

• UniProt ID: O15144
• Protein name: Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC)
• Protein function: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks
• PDB: 6UHC , 6YW6 , 6YW7 , 8P94
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04045	P34-Arc	57 → 284	Arp2/3 complex, 34 kD subunit p34-Arc	Family

• Sequence:

  MILLEVNNRIIEETLALKFENAAAGNKPEAVEVTFADFDGVLYHISNPNGDKTKVMVSIS
  LKFYKELQAHGADELLKRVYGSFLVNPESGYNVSLLYDLENLPASKDSIVHQAGMLKRNC
  FASVFEKYFQFQEEGKEGENRAVIHYRDDETMYVESKKDRVTVVFSTVFKDDDDVVIGKV
  FMQEFKEGRRASHTAPQVLFSHREPPLELKDTDAAVGDNIGYITFVLFPRHTNASARDNT
  INLIHTFRDYLHYHIKCSKAYIHTRMRAKTSDFLKVLNRARPDAEKKEMKTITGKTFSSR
  

• Sequence length: 300

Pathways

KEGG Pathway	Reactome Pathway
Endocytosis	Regulation of actin dynamics for phagocytic cup formation
Tight junction	EPHB-mediated forward signaling
Fc gamma R-mediated phagocytosis	RHO GTPases Activate WASPs and WAVEs
Regulation of actin cytoskeleton	Clathrin-mediated endocytosis
Bacterial invasion of epithelial cells	FCGR3A-mediated phagocytosis
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Yersinia infection

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (19)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Cervical cancer	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHOLELITHIASIS	—	GWAS catalog	34651315	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC LEFT-SIDED ULCERATIVE COLITIS	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLITIS, ULCERATIVE	—	CTD	18836448	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	38872215	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	26192919	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GALLSTONES	—	GWAS catalog	34651315	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	26192919	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	23251661	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	Disgenet, GWAS catalog Disgenet, GWAS catalog	26192919	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (21)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Carcinoma	Breast Carcinoma	BEFREE	30720048, 31002363		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	31002363	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	31002363	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	33960941	Associate	★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	31571309		★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	25107436	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	34938284	Associate	★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	LHGDN	18708039		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	LHGDN	18836448		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	30720048, 31002363		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	28694563		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28694563, 31571309		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	31571309		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	19332774	Stimulate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28694563, 31002363		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	28694563		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	28694563	Associate	★☆☆☆☆ Found in Text Mining only
Transitional cell carcinoma of bladder	Bladder carcinoma	BEFREE	29593429		★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	LHGDN	18836448		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ulcerative Colitis	Ulcerative colitis	BEFREE	18836448, 19861958		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ulcerative Colitis	Ulcerative colitis	CTD_human_DG	18836448		★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

Sort by: Blended Diseases Pathways Evidence source

ATG16L2 2 shared diseasesCholecystolithiasis, Gallstones 2 shared evidence sourcesGWAS catalog (Cholecystolithiasis), GWAS catalog (Gallstones) Related via 2 shared diseases including Cholecystolithiasis, Gallstones — evidence mostly GWAS catalog. DDX17 2 shared diseasesCholecystolithiasis, Gallstones 2 shared evidence sourcesGWAS catalog (Cholecystolithiasis), GWAS catalog (Gallstones) Related via 2 shared diseases including Cholecystolithiasis, Gallstones — evidence mostly GWAS catalog. FRAT2 2 shared diseasesCholecystolithiasis, Gallstones 2 shared evidence sourcesGWAS catalog (Cholecystolithiasis), GWAS catalog (Gallstones) Related via 2 shared diseases including Cholecystolithiasis, Gallstones — evidence mostly GWAS catalog. GPR61 2 shared diseasesCholecystolithiasis, Gallstones 2 shared evidence sourcesGWAS catalog (Cholecystolithiasis), GWAS catalog (Gallstones) Related via 2 shared diseases including Cholecystolithiasis, Gallstones — evidence mostly GWAS catalog. IRF2BP1 2 shared diseasesCholecystolithiasis, Gallstones 2 shared evidence sourcesGWAS catalog (Cholecystolithiasis), GWAS catalog (Gallstones) Related via 2 shared diseases including Cholecystolithiasis, Gallstones — evidence mostly GWAS catalog.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
ATG16L2	2	["Cholecystolithiasis","Gallstones"]	0	[]	2	["GWAS catalog (Cholecystolithiasis)","GWAS catalog (Gallstones)"]
DDX17	2	["Cholecystolithiasis","Gallstones"]	0	[]	2	["GWAS catalog (Cholecystolithiasis)","GWAS catalog (Gallstones)"]
FRAT2	2	["Cholecystolithiasis","Gallstones"]	0	[]	2	["GWAS catalog (Cholecystolithiasis)","GWAS catalog (Gallstones)"]
GPR61	2	["Cholecystolithiasis","Gallstones"]	0	[]	2	["GWAS catalog (Cholecystolithiasis)","GWAS catalog (Gallstones)"]
IRF2BP1	2	["Cholecystolithiasis","Gallstones"]	0	[]	2	["GWAS catalog (Cholecystolithiasis)","GWAS catalog (Gallstones)"]

Diseases Linked via Similar Genes

Diabetes mellitus type 2 Linked via 2 of 5 related genesFRAT2, GPR61 Coronary artery disease Linked via 1 of 5 related genesATG16L2 Bipolar disorder Linked via 1 of 5 related genesGPR61 Major depressive disorder Linked via 1 of 5 related genesGPR61 Metabolic syndrome Linked via 1 of 5 related genesGPR61

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Diabetes mellitus type 2	2	["FRAT2","GPR61"]
Coronary artery disease	1	["ATG16L2"]
Bipolar disorder	1	["GPR61"]
Major depressive disorder	1	["GPR61"]
Metabolic syndrome	1	["GPR61"]