Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	10096
Gene name	Actin related protein 3
Gene symbol	ACTR3
Synonyms (NCBI Gene)	ARP3
Chromosome	2
Chromosome location	2q14.1
Summary	The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamel

214 Show/Hide all (214)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022726	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT764646	hsa-miR-1224-3p	CLIP-seq
MIRT764647	hsa-miR-1236	CLIP-seq
MIRT764648	hsa-miR-1258	CLIP-seq
MIRT764649	hsa-miR-1275	CLIP-seq
MIRT764650	hsa-miR-2113	CLIP-seq
MIRT764651	hsa-miR-2355-5p	CLIP-seq
MIRT764652	hsa-miR-3177-5p	CLIP-seq
MIRT764653	hsa-miR-3675-3p	CLIP-seq
MIRT764654	hsa-miR-3976	CLIP-seq
MIRT764655	hsa-miR-4260	CLIP-seq
MIRT764656	hsa-miR-4286	CLIP-seq
MIRT764657	hsa-miR-4477a	CLIP-seq
MIRT764658	hsa-miR-4528	CLIP-seq
MIRT764659	hsa-miR-4659a-3p	CLIP-seq
MIRT764660	hsa-miR-4659b-3p	CLIP-seq
MIRT764661	hsa-miR-4665-5p	CLIP-seq
MIRT764662	hsa-miR-4690-5p	CLIP-seq
MIRT764663	hsa-miR-4711-5p	CLIP-seq
MIRT764664	hsa-miR-4775	CLIP-seq
MIRT764665	hsa-miR-498	CLIP-seq
MIRT764666	hsa-miR-518a-5p	CLIP-seq
MIRT764667	hsa-miR-527	CLIP-seq
MIRT764668	hsa-miR-550a	CLIP-seq
MIRT764669	hsa-miR-935	CLIP-seq
MIRT764647	hsa-miR-1236	CLIP-seq
MIRT1925260	hsa-miR-1261	CLIP-seq
MIRT1925261	hsa-miR-1297	CLIP-seq
MIRT1925262	hsa-miR-200b	CLIP-seq
MIRT1925263	hsa-miR-200c	CLIP-seq
MIRT1925264	hsa-miR-26a	CLIP-seq
MIRT1925265	hsa-miR-26b	CLIP-seq
MIRT1925266	hsa-miR-300	CLIP-seq
MIRT1925267	hsa-miR-3074-3p	CLIP-seq
MIRT1925268	hsa-miR-3117-5p	CLIP-seq
MIRT1925269	hsa-miR-3127-5p	CLIP-seq
MIRT1925270	hsa-miR-3133	CLIP-seq
MIRT1925271	hsa-miR-3145-3p	CLIP-seq
MIRT1925272	hsa-miR-3655	CLIP-seq
MIRT1925273	hsa-miR-381	CLIP-seq
MIRT1925274	hsa-miR-3918	CLIP-seq
MIRT1925275	hsa-miR-3941	CLIP-seq
MIRT1925276	hsa-miR-429	CLIP-seq
MIRT1925277	hsa-miR-432	CLIP-seq
MIRT1925278	hsa-miR-4422	CLIP-seq
MIRT1925279	hsa-miR-4465	CLIP-seq
MIRT1925280	hsa-miR-4511	CLIP-seq
MIRT1925281	hsa-miR-451b	CLIP-seq
MIRT764659	hsa-miR-4659a-3p	CLIP-seq
MIRT764660	hsa-miR-4659b-3p	CLIP-seq
MIRT1925282	hsa-miR-4666-3p	CLIP-seq
MIRT764662	hsa-miR-4690-5p	CLIP-seq
MIRT764663	hsa-miR-4711-5p	CLIP-seq
MIRT1925283	hsa-miR-4760-3p	CLIP-seq
MIRT1925284	hsa-miR-4778-3p	CLIP-seq
MIRT764665	hsa-miR-498	CLIP-seq
MIRT1925285	hsa-miR-511	CLIP-seq
MIRT764666	hsa-miR-518a-5p	CLIP-seq
MIRT764667	hsa-miR-527	CLIP-seq
MIRT1925286	hsa-miR-548aa	CLIP-seq
MIRT1925287	hsa-miR-574-5p	CLIP-seq
MIRT1925288	hsa-miR-664	CLIP-seq
MIRT1925289	hsa-miR-889	CLIP-seq
MIRT764669	hsa-miR-935	CLIP-seq
MIRT764649	hsa-miR-1275	CLIP-seq
MIRT1925261	hsa-miR-1297	CLIP-seq
MIRT2166786	hsa-miR-1323	CLIP-seq
MIRT2166787	hsa-miR-185	CLIP-seq
MIRT1925264	hsa-miR-26a	CLIP-seq
MIRT1925265	hsa-miR-26b	CLIP-seq
MIRT1925270	hsa-miR-3133	CLIP-seq
MIRT2166788	hsa-miR-3179	CLIP-seq
MIRT2166789	hsa-miR-3202	CLIP-seq
MIRT2166790	hsa-miR-3646	CLIP-seq
MIRT2166791	hsa-miR-3936	CLIP-seq
MIRT2166792	hsa-miR-3942-3p	CLIP-seq
MIRT764655	hsa-miR-4260	CLIP-seq
MIRT2166793	hsa-miR-4271	CLIP-seq
MIRT2166794	hsa-miR-4272	CLIP-seq
MIRT2166795	hsa-miR-4282	CLIP-seq
MIRT2166796	hsa-miR-4306	CLIP-seq
MIRT1925279	hsa-miR-4465	CLIP-seq
MIRT764657	hsa-miR-4477a	CLIP-seq
MIRT2166797	hsa-miR-4494	CLIP-seq
MIRT2166798	hsa-miR-4644	CLIP-seq
MIRT2166799	hsa-miR-4651	CLIP-seq
MIRT764661	hsa-miR-4665-5p	CLIP-seq
MIRT764662	hsa-miR-4690-5p	CLIP-seq
MIRT2166800	hsa-miR-4694-5p	CLIP-seq
MIRT764663	hsa-miR-4711-5p	CLIP-seq
MIRT2166801	hsa-miR-4725-3p	CLIP-seq
MIRT2166802	hsa-miR-4747-5p	CLIP-seq
MIRT2166803	hsa-miR-486-5p	CLIP-seq
MIRT764665	hsa-miR-498	CLIP-seq
MIRT2166804	hsa-miR-499a-5p	CLIP-seq
MIRT1925286	hsa-miR-548aa	CLIP-seq
MIRT2166805	hsa-miR-548o	CLIP-seq
MIRT2166806	hsa-miR-568	CLIP-seq
MIRT2166807	hsa-miR-608	CLIP-seq
MIRT2166808	hsa-miR-625	CLIP-seq
MIRT2166809	hsa-miR-671-5p	CLIP-seq
MIRT764669	hsa-miR-935	CLIP-seq
MIRT1925262	hsa-miR-200b	CLIP-seq
MIRT1925263	hsa-miR-200c	CLIP-seq
MIRT1925268	hsa-miR-3117-5p	CLIP-seq
MIRT1925276	hsa-miR-429	CLIP-seq
MIRT2469275	hsa-miR-105	CLIP-seq
MIRT764648	hsa-miR-1258	CLIP-seq
MIRT1925260	hsa-miR-1261	CLIP-seq
MIRT2469276	hsa-miR-1270	CLIP-seq
MIRT2469277	hsa-miR-145	CLIP-seq
MIRT1925262	hsa-miR-200b	CLIP-seq
MIRT1925263	hsa-miR-200c	CLIP-seq
MIRT2469278	hsa-miR-2052	CLIP-seq
MIRT764650	hsa-miR-2113	CLIP-seq
MIRT1925266	hsa-miR-300	CLIP-seq
MIRT1925267	hsa-miR-3074-3p	CLIP-seq
MIRT1925268	hsa-miR-3117-5p	CLIP-seq
MIRT1925269	hsa-miR-3127-5p	CLIP-seq
MIRT1925270	hsa-miR-3133	CLIP-seq
MIRT2469279	hsa-miR-3149	CLIP-seq
MIRT2469280	hsa-miR-3161	CLIP-seq
MIRT2166790	hsa-miR-3646	CLIP-seq
MIRT2469281	hsa-miR-3647-3p	CLIP-seq
MIRT1925272	hsa-miR-3655	CLIP-seq
MIRT2469282	hsa-miR-3662	CLIP-seq
MIRT1925273	hsa-miR-381	CLIP-seq
MIRT1925274	hsa-miR-3918	CLIP-seq
MIRT2166792	hsa-miR-3942-3p	CLIP-seq
MIRT2469283	hsa-miR-425	CLIP-seq
MIRT2166795	hsa-miR-4282	CLIP-seq
MIRT1925276	hsa-miR-429	CLIP-seq
MIRT1925277	hsa-miR-432	CLIP-seq
MIRT1925278	hsa-miR-4422	CLIP-seq
MIRT2469284	hsa-miR-4424	CLIP-seq
MIRT2469285	hsa-miR-4457	CLIP-seq
MIRT2469286	hsa-miR-4461	CLIP-seq
MIRT2166797	hsa-miR-4494	CLIP-seq
MIRT1925280	hsa-miR-4511	CLIP-seq
MIRT1925281	hsa-miR-451b	CLIP-seq
MIRT2469287	hsa-miR-4661-5p	CLIP-seq
MIRT1925282	hsa-miR-4666-3p	CLIP-seq
MIRT2469288	hsa-miR-4683	CLIP-seq
MIRT764662	hsa-miR-4690-5p	CLIP-seq
MIRT2469289	hsa-miR-4694-3p	CLIP-seq
MIRT2469290	hsa-miR-4698	CLIP-seq
MIRT764663	hsa-miR-4711-5p	CLIP-seq
MIRT1925283	hsa-miR-4760-3p	CLIP-seq
MIRT1925284	hsa-miR-4778-3p	CLIP-seq
MIRT2469291	hsa-miR-4789-5p	CLIP-seq
MIRT2469292	hsa-miR-494	CLIP-seq
MIRT2166804	hsa-miR-499a-5p	CLIP-seq
MIRT1925285	hsa-miR-511	CLIP-seq
MIRT2469293	hsa-miR-513b	CLIP-seq
MIRT764666	hsa-miR-518a-5p	CLIP-seq
MIRT764667	hsa-miR-527	CLIP-seq
MIRT1925286	hsa-miR-548aa	CLIP-seq
MIRT2469294	hsa-miR-548n	CLIP-seq
MIRT2469295	hsa-miR-548t	CLIP-seq
MIRT764668	hsa-miR-550a	CLIP-seq
MIRT2469296	hsa-miR-605	CLIP-seq
MIRT2469297	hsa-miR-620	CLIP-seq
MIRT1925288	hsa-miR-664	CLIP-seq
MIRT1925289	hsa-miR-889	CLIP-seq
MIRT764669	hsa-miR-935	CLIP-seq
MIRT2469298	hsa-miR-944	CLIP-seq
MIRT2469275	hsa-miR-105	CLIP-seq
MIRT764648	hsa-miR-1258	CLIP-seq
MIRT1925260	hsa-miR-1261	CLIP-seq
MIRT2469276	hsa-miR-1270	CLIP-seq
MIRT2469277	hsa-miR-145	CLIP-seq
MIRT1925262	hsa-miR-200b	CLIP-seq
MIRT1925263	hsa-miR-200c	CLIP-seq
MIRT764650	hsa-miR-2113	CLIP-seq
MIRT1925266	hsa-miR-300	CLIP-seq
MIRT1925267	hsa-miR-3074-3p	CLIP-seq
MIRT1925268	hsa-miR-3117-5p	CLIP-seq
MIRT1925269	hsa-miR-3127-5p	CLIP-seq
MIRT2469280	hsa-miR-3161	CLIP-seq
MIRT2166790	hsa-miR-3646	CLIP-seq
MIRT2469281	hsa-miR-3647-3p	CLIP-seq
MIRT1925272	hsa-miR-3655	CLIP-seq
MIRT2469282	hsa-miR-3662	CLIP-seq
MIRT1925273	hsa-miR-381	CLIP-seq
MIRT1925274	hsa-miR-3918	CLIP-seq
MIRT2166792	hsa-miR-3942-3p	CLIP-seq
MIRT2166795	hsa-miR-4282	CLIP-seq
MIRT1925276	hsa-miR-429	CLIP-seq
MIRT1925277	hsa-miR-432	CLIP-seq
MIRT1925278	hsa-miR-4422	CLIP-seq
MIRT2469284	hsa-miR-4424	CLIP-seq
MIRT2166797	hsa-miR-4494	CLIP-seq
MIRT1925281	hsa-miR-451b	CLIP-seq
MIRT2469287	hsa-miR-4661-5p	CLIP-seq
MIRT1925282	hsa-miR-4666-3p	CLIP-seq
MIRT2469288	hsa-miR-4683	CLIP-seq
MIRT764662	hsa-miR-4690-5p	CLIP-seq
MIRT2469289	hsa-miR-4694-3p	CLIP-seq
MIRT2469290	hsa-miR-4698	CLIP-seq
MIRT764663	hsa-miR-4711-5p	CLIP-seq
MIRT1925283	hsa-miR-4760-3p	CLIP-seq
MIRT1925284	hsa-miR-4778-3p	CLIP-seq
MIRT2469291	hsa-miR-4789-5p	CLIP-seq
MIRT2469292	hsa-miR-494	CLIP-seq
MIRT2166804	hsa-miR-499a-5p	CLIP-seq
MIRT1925285	hsa-miR-511	CLIP-seq
MIRT764666	hsa-miR-518a-5p	CLIP-seq
MIRT764667	hsa-miR-527	CLIP-seq
MIRT764668	hsa-miR-550a	CLIP-seq
MIRT2469296	hsa-miR-605	CLIP-seq
MIRT2469297	hsa-miR-620	CLIP-seq
MIRT1925288	hsa-miR-664	CLIP-seq
MIRT1925289	hsa-miR-889	CLIP-seq
MIRT764669	hsa-miR-935	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003779	Function	Actin binding	IEA
GO:0005200	Function	Structural constituent of cytoskeleton	IDA	11741539
GO:0005515	Function	Protein binding	IPI	20195357, 29058690, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	16767080, 17220302
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	17220302
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005885	Component	Arp2/3 protein complex	IBA
GO:0005885	Component	Arp2/3 protein complex	IDA	11741539, 17220302
GO:0005885	Component	Arp2/3 protein complex	TAS	9230079
GO:0005903	Component	Brush border	IEA
GO:0005911	Component	Cell-cell junction	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0007163	Process	Establishment or maintenance of cell polarity	IEA
GO:0008356	Process	Asymmetric cell division	IEA
GO:0010592	Process	Positive regulation of lamellipodium assembly	IDA	29058690
GO:0015629	Component	Actin cytoskeleton	TAS	9230079
GO:0016020	Component	Membrane	HDA	19946888
GO:0016344	Process	Meiotic chromosome movement towards spindle pole	IEA
GO:0030027	Component	Lamellipodium	IDA	9230079
GO:0030027	Component	Lamellipodium	IEA
GO:0030030	Process	Cell projection organization	IEA
GO:0033206	Process	Meiotic cytokinesis	IEA
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IBA
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IDA	11741539, 17220302
GO:0035861	Component	Site of double-strand break	ISS
GO:0042995	Component	Cell projection	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	17220302
GO:0051015	Function	Actin filament binding	IBA
GO:0051015	Function	Actin filament binding	IDA	11741539
GO:0051321	Process	Meiotic cell cycle	IEA
GO:0051653	Process	Spindle localization	IEA
GO:0060271	Process	Cilium assembly	IMP	20393563
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0070358	Process	Actin polymerization-dependent cell motility	TAS	9230079
GO:0071346	Process	Cellular response to type II interferon	IEA

MIM	HGNC	e!Ensembl
604222	170	ENSG00000115091

P61158

Protein name

Actin-related protein 3 (Actin-like protein 3)

Protein function

ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks i

PDB

6UHC , 6YW6 , 6YW7 , 8P94

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00022	Actin	2 → 412	Actin	Family

Sequence

MAGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVGDQAQRRVMKGVDDLDF
FIGDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTP
ENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPV
AEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVK
EFNKYDTDGSKWIKQYTGINAISKKEFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVV
DEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKP
KPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFGVMS

Sequence length

418

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Endocytosis	Regulation of actin dynamics for phagocytic cup formation
Tight junction	EPHB-mediated forward signaling
Fc gamma R-mediated phagocytosis	RHO GTPases Activate WASPs and WAVEs
Regulation of actin cytoskeleton	Clathrin-mediated endocytosis
Bacterial invasion of epithelial cells	FCGR3A-mediated phagocytosis
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Yersinia infection

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
ARPC5	[]	14	["Endocytosis","Tight junction","Fc gamma R-mediated phagocytosis","Regulation of actin cytoskeleton","Bacterial invasion of epithelial cells","Pathogenic Escherichia coli infection","Shigellosis","Salmonella infection","Yersinia infection","Regulation of actin dynamics for phagocytic cup formation","RHO GTPases Activate WASPs and WAVEs","FCGR3A-mediated phagocytosis"]	[]
ARPC4	[]	14	["Endocytosis","Tight junction","Fc gamma R-mediated phagocytosis","Regulation of actin cytoskeleton","Bacterial invasion of epithelial cells","Pathogenic Escherichia coli infection","Shigellosis","Salmonella infection","Yersinia infection","Regulation of actin dynamics for phagocytic cup formation","RHO GTPases Activate WASPs and WAVEs","FCGR3A-mediated phagocytosis"]	[]
ARPC3	[]	14	["Endocytosis","Tight junction","Fc gamma R-mediated phagocytosis","Regulation of actin cytoskeleton","Bacterial invasion of epithelial cells","Pathogenic Escherichia coli infection","Shigellosis","Salmonella infection","Yersinia infection","Regulation of actin dynamics for phagocytic cup formation","RHO GTPases Activate WASPs and WAVEs","FCGR3A-mediated phagocytosis"]	[]
ACTR2	[]	14	["Endocytosis","Tight junction","Fc gamma R-mediated phagocytosis","Regulation of actin cytoskeleton","Bacterial invasion of epithelial cells","Pathogenic Escherichia coli infection","Shigellosis","Salmonella infection","Yersinia infection","Regulation of actin dynamics for phagocytic cup formation","RHO GTPases Activate WASPs and WAVEs","FCGR3A-mediated phagocytosis"]	[]
ARPC2	[]	14	["Endocytosis","Tight junction","Fc gamma R-mediated phagocytosis","Regulation of actin cytoskeleton","Bacterial invasion of epithelial cells","Pathogenic Escherichia coli infection","Shigellosis","Salmonella infection","Yersinia infection","Regulation of actin dynamics for phagocytic cup formation","RHO GTPases Activate WASPs and WAVEs","FCGR3A-mediated phagocytosis"]	[]

ACTR3 (actin related protein 3)

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