Kidney disease

PPAR signaling pathway Fat digestion and absorption Vitamin digestion and absorption Cholesterol metabolism African trypanosomiasis Lipid and atherosclerosis Platelet degranulation ABC transporters in lipid homeostasis PPARA activates gene expression Scavenging of heme from plasma Scavenging by Class B Receptors Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective ABCA1 causes Tangier disease Post-translational protein phosphorylation Chylomicron assembly HDL assembly Chylomicron remodeling HDL clearance HDL remodeling Retinoid metabolism and transport Amyloid fiber formation +19 more

Neurotrophin signaling pathway Vasopressin-regulated water reabsorption Axonal growth inhibition (RHOA activation) Rho GTPase cycle Axonal growth stimulation +2 more

Purine metabolism One carbon pool by folate Metabolic pathways Antifolate resistance Purine ribonucleoside monophosphate biosynthesis +2 more

Complement and coagulation cascades Staphylococcus aureus infection Regulation of Complement cascade

Complement and coagulation cascades Regulation of Complement cascade

Complement and coagulation cascades Regulation of Complement cascade

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Cytoskeleton in muscle cells Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Protein digestion and absorption Amoebiasis Human papillomavirus infection Pathways in cancer Small cell lung cancer Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Non-integrin membrane-ECM interactions NCAM1 interactions Collagen chain trimerization +20 more

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Cytoskeleton in muscle cells Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Protein digestion and absorption Amoebiasis Human papillomavirus infection Pathways in cancer Small cell lung cancer Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Non-integrin membrane-ECM interactions NCAM1 interactions Collagen chain trimerization +20 more

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Cytoskeleton in muscle cells Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Protein digestion and absorption Amoebiasis Human papillomavirus infection Pathways in cancer Small cell lung cancer Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Non-integrin membrane-ECM interactions NCAM1 interactions Collagen chain trimerization +20 more

Vitamin digestion and absorption Cobalamin (Cbl, vitamin B12) transport and metabolism Vitamin D (calciferol) metabolism Defective AMN causes hereditary megaloblastic anemia 1 Defective CUBN causes hereditary megaloblastic anemia 1 HDL clearance +3 more

Fatty acid degradation Valine, leucine and isoleucine degradation Lysine degradation Tryptophan metabolism beta-Alanine metabolism Propanoate metabolism Butanoate metabolism Metabolic pathways Fatty acid metabolism PPAR signaling pathway Peroxisome Beta-oxidation of very long chain fatty acids Peroxisomal protein import +10 more

Respiratory electron transport Protein methylation

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Regulation of actin cytoskeleton Cytoskeleton in muscle cells AGE-RAGE signaling pathway in diabetic complications Bacterial invasion of epithelial cells Yersinia infection Amoebiasis Human papillomavirus infection Pathways in cancer Proteoglycans in cancer Small cell lung cancer Platelet degranulation Degradation of the extracellular matrix Extracellular matrix organization Fibronectin matrix formation Cell surface interactions at the vascular wall Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MAP2K and MAPK activation Interleukin-4 and Interleukin-13 signaling Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates PTK2 signaling Post-translational protein phosphorylation Signaling downstream of RAS mutants +33 more

ECM-receptor interaction

N-Glycan biosynthesis Metabolic pathways Protein processing in endoplasmic reticulum N-glycan trimming in the ER and Calnexin/Calreticulin cycle Calnexin/calreticulin cycle +2 more

Hedgehog 'off' state Anchoring of the basal body to the plasma membrane

Nephrin family interactions

VxPx cargo-targeting to cilium

Sodium-coupled sulphate, di- and tri-carboxylate transporters

Wnt signaling pathway Deactivation of the beta-catenin transactivating complex

mTOR signaling pathway Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells Melanogenesis Cushing syndrome Alzheimer disease Pathways of neurodegeneration - multiple diseases Human papillomavirus infection Pathways in cancer Proteoglycans in cancer Basal cell carcinoma Breast cancer Hepatocellular carcinoma Gastric cancer WNT ligand biogenesis and trafficking +13 more

Transcriptional misregulation in cancer

Endocytosis

Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

Autophagy - other Autophagy - animal Ferroptosis Neutrophil extracellular trap formation Macroautophagy Neutrophil degranulation Signaling by BRAF and RAF fusions Antigen processing: Ubiquitination & Proteasome degradation +5 more

Neuroactive ligand-receptor interaction Hormone signaling Osteoclast differentiation G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production +3 more

Neutrophil degranulation

Adherens junctions interactions

Complement and coagulation cascades Staphylococcus aureus infection Regulation of Complement cascade

Pre-NOTCH Transcription and Translation

Purine metabolism Metabolic pathways Small cell lung cancer Non-small cell lung cancer +1 more

Basal transcription factors cGMP-PKG signaling pathway

Glycosaminoglycan degradation Metabolic pathways Lysosome HS-GAG degradation CS/DS degradation MPS II - Hunter syndrome +3 more

Wnt signaling pathway

VxPx cargo-targeting to cilium

Complement and coagulation cascades Staphylococcus aureus infection Regulation of Complement cascade

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Cytoskeleton in muscle cells Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Protein digestion and absorption Amoebiasis Human papillomavirus infection Pathways in cancer Small cell lung cancer Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Non-integrin membrane-ECM interactions NCAM1 interactions Collagen chain trimerization +20 more

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Cytoskeleton in muscle cells Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Protein digestion and absorption Amoebiasis Human papillomavirus infection Pathways in cancer Small cell lung cancer Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Non-integrin membrane-ECM interactions NCAM1 interactions Collagen chain trimerization +20 more

Wnt signaling pathway

Nephrin family interactions

Transcriptional misregulation in cancer