Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
KIDNEY DISEASE	EFO_0003086	MAF	Unknown	39024449	GWAS catalog	Th1 and Th2 cell differentiation Transcriptional misregulation in cancer Inflammatory bowel disease
		NOTCH4	Unknown	20595679	GWAS catalog	Endocrine resistance Notch signaling pathway Thyroid hormone signaling pathway +11 more
		NUAK1	Unknown	39024449	GWAS catalog	Regulation of TP53 Activity through Phosphorylation
		OTOL1	Unknown	39024449	GWAS catalog	—
		PAX7	Unknown	39024449	GWAS catalog	Transcriptional misregulation in cancer
		PCOLCE2	Unknown	39024449	GWAS catalog	Collagen biosynthesis and modifying enzymes
		PSMB8	Unknown	21399633	GWAS catalog	Proteasome Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha +50 more
		RNF13	Unknown	39024449	GWAS catalog	—
		STARD13	Unknown	39024449	GWAS catalog	Rho GTPase cycle
		TPD52L3	Unknown	39024449	GWAS catalog	—
		UHRF2	Unknown	39024449	GWAS catalog	SUMOylation of transcription cofactors
KIDNEY DISEASES	C0022658 MESH:D007674	ABCB1	Unknown	—	Disgenet	ABC transporters Bile secretion MicroRNAs in cancer +2 more
		ACE	Unknown	8642790	CTD, Disgenet	Renin-angiotensin system Renin secretion Chagas disease +4 more
		ACKR3	Unknown	22880115	CTD, Disgenet	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine receptors bind chemokines +1 more
		ACTA2	Unknown	19913069 31697999	CTD, Disgenet	Vascular smooth muscle contraction Apelin signaling pathway Motor proteins +3 more
		ADRA1B	Unknown	18257748	CTD, Disgenet	Calcium signaling pathway cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction +7 more
		AGT	Unknown	12414515 15213268 17989111 21896938 31098697	CTD, Disgenet	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +18 more
		AGTR1	Unknown	15213268	CTD, Disgenet	Calcium signaling pathway cGMP-PKG signaling pathway Phospholipase D signaling pathway +18 more
		ALAD	Unknown	23792432 24631795	CTD, Disgenet	Porphyrin metabolism Metabolic pathways Biosynthesis of cofactors +2 more
		ALB	Unknown	16316336 17303580 20438795 21338618 2386429 24863737 350256 7297036	CTD, Disgenet	Thyroid hormone synthesis Platelet degranulation Recycling of bile acids and salts +7 more
		ALOX5AP	Unknown	—	Disgenet	Fc epsilon RI signaling pathway Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) +1 more
		ANKFY1	Unknown	—	Disgenet	—
		ANXA1	Unknown	20484890	CTD, Disgenet	G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands +1 more
		APC	Unknown	35362542	CTD, Disgenet	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		B2M	Unknown	17303580 2202081 24863737	CTD, Disgenet	Antigen processing and presentation Human cytomegalovirus infection Human T-cell leukemia virus 1 infection +14 more
		CALB1	Unknown	21258088 21865292	CTD, Disgenet	Endocrine and other factor-regulated calcium reabsorption Amyloid fiber formation
		CASP1	Unknown	22647887	CTD, Disgenet	Efferocytosis Necroptosis Neutrophil extracellular trap formation +20 more
		CD46	Unknown	—	Disgenet	Virion - Ebolavirus, Lyssavirus and Morbillivirus Virion - Adenovirus Complement and coagulation cascades +2 more
		CD59	Unknown	31618666	CTD, Disgenet	Complement and coagulation cascades Hematopoietic cell lineage COPII-mediated vesicle transport +4 more
		CDH1	Unknown	31697999	CTD, Disgenet	Rap1 signaling pathway Apelin signaling pathway Hippo signaling pathway +15 more
		CDKN1A	Unknown	16968891	CTD, Disgenet	Endocrine resistance Platinum drug resistance ErbB signaling pathway +56 more
		CEP290	Unknown	—	Disgenet	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +5 more
		CFHR3	Unknown	—	Disgenet	Complement and coagulation cascades Regulation of Complement cascade
		CFHR4	Unknown	—	Disgenet	Complement and coagulation cascades Regulation of Complement cascade
		CLU	Unknown	21258088 21593213 24863737	CTD, Disgenet	Complement and coagulation cascades Platelet degranulation Terminal pathway of complement +2 more
		CNNM2	Unknown	23027747	CTD, Disgenet	—
		COQ2	Unknown	—	Disgenet	Ubiquinone and other terpenoid-quinone biosynthesis Metabolic pathways Biosynthesis of cofactors
		CSF3	Unknown	19429242	CTD, Disgenet	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway +6 more
		CTF1	Unknown	23335628	CTD, Disgenet	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway IL-6-type cytokine receptor ligand interactions
		CTLA4	Unknown	—	Disgenet	Cell adhesion molecules T cell receptor signaling pathway Autoimmune thyroid disease +3 more
		CTSD	Unknown	15213268	CTD, Disgenet	Sphingolipid signaling pathway Autophagy - animal Lysosome +9 more
		CYBB	Unknown	20116427	CTD, Disgenet	HIF-1 signaling pathway Phagosome Ferroptosis +18 more
		CYP2C8	Unknown	18769365	CTD, Disgenet	Arachidonic acid metabolism Linoleic acid metabolism Retinol metabolism +10 more
		CYP3A5	Unknown	18408564 20526235	CTD, Disgenet	Steroid hormone biosynthesis Retinol metabolism Metabolism of xenobiotics by cytochrome P450 +5 more
		DGKE	Unknown	—	Disgenet	Glycerolipid metabolism Glycerophospholipid metabolism Metabolic pathways +4 more
		EDN1	Unknown	10399635 15106802 8604712	CTD, Disgenet	cAMP signaling pathway HIF-1 signaling pathway Neuroactive ligand-receptor interaction +11 more
		EGF	Unknown	21865292	CTD, Disgenet	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +57 more
		EPO	Unknown	20606417 32909846	CTD, Disgenet	Cytokine-cytokine receptor interaction HIF-1 signaling pathway Hormone signaling +8 more
		FABP4	Unknown	30215792	CTD, Disgenet	PPAR signaling pathway Regulation of lipolysis in adipocytes Triglyceride catabolism +1 more
		FAS	Unknown	38555047	CTD, Disgenet	Platinum drug resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +36 more
KIDNEY DISORDER	MONDO:0005240	ANKFY1	Unknown	—	GenCC	—

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Kidney disease

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