Kidney disease

Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system Phospholipase D signaling pathway Endocytosis Focal adhesion Fc gamma R-mediated phagocytosis Regulation of actin cytoskeleton Yersinia infection Choline metabolism in cancer Synthesis of PIPs at the plasma membrane WNT mediated activation of DVL PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling +10 more

Inositol phosphate metabolism Metabolic pathways Rap1 signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway Chemokine signaling pathway Phosphatidylinositol signaling system Sphingolipid signaling pathway Phospholipase D signaling pathway Hormone signaling Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Wnt signaling pathway Apelin signaling pathway Gap junction Platelet activation Neutrophil extracellular trap formation NOD-like receptor signaling pathway Circadian entrainment Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse Dopaminergic synapse Long-term depression Taste transduction Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Estrogen signaling pathway Melanogenesis Thyroid hormone synthesis Thyroid hormone signaling pathway Oxytocin signaling pathway Glucagon signaling pathway Renin secretion Aldosterone synthesis and secretion Relaxin signaling pathway Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action GnRH secretion AGE-RAGE signaling pathway in diabetic complications Cushing syndrome Growth hormone synthesis, secretion and action Endocrine and other factor-regulated calcium reabsorption Salivary secretion Gastric acid secretion Pancreatic secretion Carbohydrate digestion and absorption Alzheimer disease Huntington disease Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Shigellosis Chagas disease African trypanosomiasis Amoebiasis Human cytomegalovirus infection Pathways in cancer Diabetic cardiomyopathy Lipid and atherosclerosis PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors +67 more

Inositol phosphate metabolism Metabolic pathways Rap1 signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway Chemokine signaling pathway Phosphatidylinositol signaling system Sphingolipid signaling pathway Phospholipase D signaling pathway Hormone signaling Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Wnt signaling pathway Apelin signaling pathway Gap junction Platelet activation Neutrophil extracellular trap formation NOD-like receptor signaling pathway Circadian entrainment Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse Dopaminergic synapse Long-term depression Taste transduction Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Estrogen signaling pathway Melanogenesis Thyroid hormone synthesis Thyroid hormone signaling pathway Oxytocin signaling pathway Glucagon signaling pathway Renin secretion Aldosterone synthesis and secretion Relaxin signaling pathway Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action GnRH secretion AGE-RAGE signaling pathway in diabetic complications Cushing syndrome Growth hormone synthesis, secretion and action Endocrine and other factor-regulated calcium reabsorption Salivary secretion Gastric acid secretion Pancreatic secretion Carbohydrate digestion and absorption Alzheimer disease Huntington disease Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Shigellosis Chagas disease African trypanosomiasis Amoebiasis Human cytomegalovirus infection Pathways in cancer Diabetic cardiomyopathy Lipid and atherosclerosis PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors +67 more

Neuroactive ligand-receptor interaction Complement and coagulation cascades Staphylococcus aureus infection Influenza A Platelet degranulation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Signaling by PDGF Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Dissolution of Fibrin Clot +7 more

FoxO signaling pathway AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Apelin signaling pathway Tight junction Circadian rhythm Thermogenesis Insulin signaling pathway Adipocytokine signaling pathway Oxytocin signaling pathway Glucagon signaling pathway Insulin resistance Non-alcoholic fatty liver disease Alcoholic liver disease Hypertrophic cardiomyopathy Macroautophagy AMPK inhibits chREBP transcriptional activation activity Carnitine metabolism Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation +19 more

Transcriptional misregulation in cancer

Endocytosis

Proteasome Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Spinocerebellar ataxia Prion disease Pathways of neurodegeneration - multiple diseases Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants that don't undergo autocatalytic processing are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Neutrophil degranulation CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Interleukin-1 signaling Antigen processing: Ubiquitination & Proteasome degradation +57 more

Apoptosis Synthesis of PIPs at the plasma membrane Interleukin-37 signaling

Cell adhesion molecules Adherens junction

TBC/RABGAPs

Endocrine resistance Cell cycle Cellular senescence Cushing syndrome Hepatitis C Hepatitis B Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Pathways in cancer Viral carcinogenesis Chemical carcinogenesis - receptor activation Pancreatic cancer Glioma Prostate cancer Melanoma Bladder cancer Chronic myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Inhibition of replication initiation of damaged DNA by RB1/E2F1 Condensation of Prophase Chromosomes Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry +30 more

Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis

Rap1 signaling pathway G alpha (i) signalling events

G alpha (q) signalling events G alpha (i) signalling events

RAB GEFs exchange GTP for GDP on RABs

Nicotinamide salvaging

mRNA surveillance pathway mRNA Capping RNA Pol II CTD phosphorylation and interaction with CE

Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +7 more

N-Glycan biosynthesis Various types of N-glycan biosynthesis Metabolic pathways Protein processing in endoplasmic reticulum Asparagine N-linked glycosylation +2 more

Purine metabolism Pyrimidine metabolism Glutathione metabolism Drug metabolism - other enzymes Metabolic pathways Nucleotide metabolism p53 signaling pathway Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6 +7 more

Virion - Hepatitis viruses Phagosome Ovarian steroidogenesis Aldosterone synthesis and secretion Cortisol synthesis and secretion Cushing syndrome Fat digestion and absorption Bile secretion Vitamin digestion and absorption Cholesterol metabolism Hepatitis C Scavenging by Class B Receptors HDL clearance +10 more

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation

Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 +4 more

Polycomb repressive complex

Amino acids regulate mTORC1

Endocytosis EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis +2 more

Rap1 signaling pathway

Sodium-coupled sulphate, di- and tri-carboxylate transporters

Central carbon metabolism in cancer Basigin interactions Proton-coupled monocarboxylate transport Pyruvate metabolism +1 more

Choline metabolism in cancer Neurotransmitter clearance Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport Na+/Cl- dependent neurotransmitter transporters Organic cation transport +3 more

Sodium/Calcium exchangers

Olfactory transduction Sodium/Calcium exchangers Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI)

Transport of inorganic cations/anions and amino acids/oligopeptides

Cellular hexose transport Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)

Mineral absorption Zinc efflux and compartmentalization by the SLC30 family

Insulin processing Zinc efflux and compartmentalization by the SLC30 family

Parathyroid hormone synthesis, secretion and action Mineral absorption Type II Na+/Pi cotransporters Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1) Surfactant metabolism +2 more

Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) Transport of nucleotide sugars

Nicotinamide salvaging

FoxO signaling pathway AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Apelin signaling pathway Tight junction Circadian rhythm Thermogenesis Insulin signaling pathway Adipocytokine signaling pathway Oxytocin signaling pathway Glucagon signaling pathway Insulin resistance Non-alcoholic fatty liver disease Alcoholic liver disease Hypertrophic cardiomyopathy Macroautophagy AMPK inhibits chREBP transcriptional activation activity Carnitine metabolism Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation +19 more

Virion - Hepatitis viruses Phagosome Ovarian steroidogenesis Aldosterone synthesis and secretion Cortisol synthesis and secretion Cushing syndrome Fat digestion and absorption Bile secretion Vitamin digestion and absorption Cholesterol metabolism Hepatitis C Scavenging by Class B Receptors HDL clearance +10 more

Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 +4 more

Choline metabolism in cancer Neurotransmitter clearance Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport Na+/Cl- dependent neurotransmitter transporters Organic cation transport +3 more

Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 +4 more