Kidney disease

Motor proteins COPI-dependent Golgi-to-ER retrograde traffic Kinesins

Negative regulation of TCF-dependent signaling by WNT ligand antagonists Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling

Polycomb repressive complex

Oxidative phosphorylation Purine ribonucleoside monophosphate biosynthesis

Cholesterol metabolism

Signaling by EGFR Negative regulation of MET activity

Hedgehog signaling pathway Thyroid hormone synthesis Cholesterol metabolism Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Retinoid metabolism and transport +4 more

Post-translational modification: synthesis of GPI-anchored proteins

Regulation of TNFR1 signaling RAB GEFs exchange GTP for GDP on RABs

MAPK signaling pathway Oxidative Stress Induced Senescence MAPK6/MAPK4 signaling Regulation of TP53 Activity through Phosphorylation +1 more

Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +2 more

Tight junction

MAPK signaling pathway HIF-1 signaling pathway Insulin signaling pathway Spry regulation of FGF signaling +1 more

Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation +2 more

Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo

Mitochondrial translation elongation Mitochondrial translation termination

Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis +3 more

Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction Regulation of actin cytoskeleton Motor proteins Cytoskeleton in muscle cells Pathogenic Escherichia coli infection Regulation of actin dynamics for phagocytic cup formation RHO GTPases activate PAKs CD163 mediating an anti-inflammatory response FCGR3A-mediated phagocytosis +8 more

Motor proteins

Cytoskeleton in muscle cells

Glutathione metabolism Metabolic pathways Amyloid fiber formation

Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways HS-GAG biosynthesis

MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Efferocytosis Cellular senescence Wnt signaling pathway Osteoclast differentiation C-type lectin receptor signaling pathway Natural killer cell mediated cytotoxicity Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway B cell receptor signaling pathway Oxytocin signaling pathway AGE-RAGE signaling pathway in diabetic complications Yersinia infection Hepatitis B Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection PD-L1 expression and PD-1 checkpoint pathway in cancer Inflammatory bowel disease Lipid and atherosclerosis Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation +26 more

Necroptosis NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Yersinia infection Influenza A Coronavirus disease - COVID-19 Lipid and atherosclerosis Metalloprotease DUBs The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection +12 more

Membrane binding and targetting of GAG proteins Inactivation, recovery and regulation of the phototransduction cascade

Signaling by Hippo Anchoring of the basal body to the plasma membrane

PPAR signaling pathway Efferocytosis Insulin resistance Non-alcoholic fatty liver disease Hepatitis C PPARA activates gene expression Nuclear Receptor transcription pathway SUMOylation of intracellular receptors VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis +12 more

EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants +18 more

ErbB signaling pathway Amyotrophic lateral sclerosis Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling PIP3 activates AKT signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants +15 more

Olfactory transduction Olfactory Signaling Pathway

Base excision repair NF-kappa B signaling pathway Apoptosis Necroptosis Diabetic cardiomyopathy POLB-Dependent Long Patch Base Excision Repair Downregulation of SMAD2/3:SMAD4 transcriptional activity SUMOylation of DNA damage response and repair proteins HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER +9 more

Maturity onset diabetes of the young

Purine metabolism Metabolic pathways cAMP signaling pathway Parathyroid hormone synthesis, secretion and action Morphine addiction DARPP-32 events G alpha (s) signalling events +4 more

Hedgehog signaling pathway Thyroid hormone synthesis Cholesterol metabolism Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Retinoid metabolism and transport +4 more

Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction Regulation of actin cytoskeleton Motor proteins Cytoskeleton in muscle cells Pathogenic Escherichia coli infection Regulation of actin dynamics for phagocytic cup formation RHO GTPases activate PAKs CD163 mediating an anti-inflammatory response FCGR3A-mediated phagocytosis +8 more

Necroptosis NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Yersinia infection Influenza A Coronavirus disease - COVID-19 Lipid and atherosclerosis Metalloprotease DUBs The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection +12 more

Signaling by Hippo Anchoring of the basal body to the plasma membrane

Base excision repair NF-kappa B signaling pathway Apoptosis Necroptosis Diabetic cardiomyopathy POLB-Dependent Long Patch Base Excision Repair Downregulation of SMAD2/3:SMAD4 transcriptional activity SUMOylation of DNA damage response and repair proteins HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER +9 more