Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
BIPOLAR DISORDER	C0005586 MONDO_0004985 MESH:D001714	LARS2	Unknown	—	Disgenet	Aminoacyl-tRNA biosynthesis Mitochondrial tRNA aminoacylation
		LAYN	Unknown	31043756	GWAS catalog	—
		LBX1	Unknown	—	Disgenet	—
		LDHA	Unknown	—	Disgenet	Glycolysis / Gluconeogenesis Cysteine and methionine metabolism Pyruvate metabolism +6 more
		LETM2	Unknown	31043756 33479212 34159505	GWAS catalog	—
		LHX5	Unknown	—	Disgenet	Signaling pathways regulating pluripotency of stem cells
		LIG4	Unknown	23453885	GWAS catalog	Non-homologous end-joining 2-LTR circle formation Nonhomologous End-Joining (NHEJ)
		LINGO2	Unknown	31754094	GWAS catalog	—
		LMAN2L	Unknown	18711365 20351715 21926972 22182935 28072414 31043756 31835028 32606422 33479212 33686288 34002096 34159505	CTD, Disgenet, GWAS catalog	COPII-mediated vesicle transport Cargo concentration in the ER
		LORICRIN	Unknown	34099189	GWAS catalog	Formation of the cornified envelope
		LPP	Unknown	23218918	GWAS catalog	—
		LRATD1	Unknown	34099189	GWAS catalog	—
		LRFN5	Unknown	31835028	GWAS catalog	—
		LRP1B	Unknown	34099189	GWAS catalog	—
		LRRC3C	Unknown	31043756	GWAS catalog	—
		LRRFIP2	Unknown	38858783	GWAS catalog	—
		LSAMP	Unknown	23218918	GWAS catalog	Post-translational modification: synthesis of GPI-anchored proteins
		LSM8	Unknown	33686288	GWAS catalog	RNA degradation Spliceosome mRNA Splicing - Major Pathway
		LY6K	Unknown	36753304	GWAS catalog	Post-translational modification: synthesis of GPI-anchored proteins
		LYRM2	Unknown	25827505	GWAS catalog	—
		LYZL4	Unknown	34099189	GWAS catalog	—
		MACROD1	Unknown	31043756 33479212 38154582	GWAS catalog	—
		MACROD2	Unknown	31043756 32606422 33169155 38858783	GWAS catalog	—
		MAD1L1	Unknown	20889312 21926972 23453885 24166486 24280982 27329760 28115744 31043756 31835028 32606422 33479212 34002096 34159505 34976021 38154582	GWAS catalog	Cell cycle Oocyte meiosis Progesterone-mediated oocyte maturation +8 more
		MAF	Unknown	33686288	GWAS catalog	Th1 and Th2 cell differentiation Transcriptional misregulation in cancer Inflammatory bowel disease
		MAGI1	Unknown	—	Disgenet	Rap1 signaling pathway PI3K-Akt signaling pathway Tight junction +1 more
		MAGI2	Unknown	—	Disgenet	Rap1 signaling pathway PI3K-Akt signaling pathway
		MAIP1	Unknown	29121268 33479212	GWAS catalog	Processing of SMDT1
		MAOA	Unknown	—	Disgenet	Glycine, serine and threonine metabolism Arginine and proline metabolism Histidine metabolism +18 more
		MAOB	Unknown	—	Disgenet	Glycine, serine and threonine metabolism Arginine and proline metabolism Histidine metabolism +12 more
		MAP1LC3A	Unknown	38858783	GWAS catalog	Mitophagy - animal Autophagy - animal Ferroptosis +9 more
		MAP2	Unknown	31043756	Disgenet, GWAS catalog	—
		MAP2K5	Unknown	31754094	GWAS catalog	MAPK signaling pathway Gap junction Neurotrophin signaling pathway +2 more
		MAPK1	Unknown	31043756	Disgenet, GWAS catalog	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +161 more
		MAPK8IP1	Unknown	31043756	GWAS catalog	MAPK signaling pathway
		MARK2	Unknown	31926635	GWAS catalog	—
		MATN1	Unknown	23092984	GWAS catalog	ECM proteoglycans
		MAU2	Unknown	24618891 33479212 33686288 34159505	GWAS catalog	Cell cycle Cohesin Loading onto Chromatin
		MBD2	Unknown	38154582	GWAS catalog	ATP-dependent chromatin remodeling NoRC negatively regulates rRNA expression RNA Polymerase I Promoter Opening
		MBD5	Unknown	—	Disgenet	Polycomb repressive complex UCH proteinases
		MBL2	Unknown	—	Disgenet	Phagosome Complement and coagulation cascades Staphylococcus aureus infection +3 more
		MC2R	Unknown	—	Disgenet	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +7 more
		MCC	Unknown	20889312	GWAS catalog	Wnt signaling pathway
		MCHR1	Unknown	32606422 34002096	Disgenet, GWAS catalog	Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors +3 more
		MCHR2	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors +2 more
		MCTP1	Unknown	19416921 31043756	GWAS catalog	—
		MDFIC	Unknown	34099189	GWAS catalog	Viral life cycle - HIV-1
		MDGA1	Unknown	—	Disgenet	Post-translational modification: synthesis of GPI-anchored proteins
		MDH1	Unknown	39024449	GWAS catalog	Citrate cycle (TCA cycle) Cysteine and methionine metabolism Pyruvate metabolism +5 more
		ME1	Unknown	33169155	GWAS catalog	Pyruvate metabolism Metabolic pathways Carbon metabolism +3 more
BIPOLAR I DISORDER	EFO_0009963	LMAN2L	Unknown	34002096	GWAS catalog	COPII-mediated vesicle transport Cargo concentration in the ER
		LRRC3C	Unknown	31043756	GWAS catalog	—
		MACROD2	Unknown	31043756	GWAS catalog	—
		MAD1L1	Unknown	31043756 34002096 35912095	GWAS catalog	Cell cycle Oocyte meiosis Progesterone-mediated oocyte maturation +8 more
		MAPK8IP1	Unknown	31043756	GWAS catalog	MAPK signaling pathway
BIPOLAR I DISORDER, MOST RECENT EPISODE MANIC	C0024713	LMAN2L	Unknown	—	Disgenet	COPII-mediated vesicle transport Cargo concentration in the ER
BIPOLAR I DISORDER, MOST RECENT EPISODE MANIC	C0024713	MBL2	Unknown	—	Disgenet	Phagosome Complement and coagulation cascades Staphylococcus aureus infection +3 more
BIPOLAR II DISORDER	EFO_0009964	MAD1L1	Unknown	35912095	GWAS catalog	Cell cycle Oocyte meiosis Progesterone-mediated oocyte maturation +8 more
MIXED BIPOLAR I DISORDER	C0236780	LMAN2L	Unknown	—	Disgenet	COPII-mediated vesicle transport Cargo concentration in the ER
MIXED BIPOLAR I DISORDER	C0236780	MBL2	Unknown	—	Disgenet	Phagosome Complement and coagulation cascades Staphylococcus aureus infection +3 more

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