Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
BIPOLAR DISORDER	MONDO_0004985 C0005586 MESH:D001714	HNRNPC	Unknown	21738484	GWAS catalog	Spliceosome SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway +1 more
		HOMER2	Unknown	34002096	GWAS catalog	FoxO signaling pathway Glutamatergic synapse Neurexins and neuroligins
		HPGDS	Unknown	—	Disgenet	Glutathione metabolism Arachidonic acid metabolism Metabolism of xenobiotics by cytochrome P450 +5 more
		HSP90B1	Unknown	—	Disgenet	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway IL-17 signaling pathway +14 more
		HSPA4	Unknown	—	Disgenet	Tight junction Antigen processing and presentation Lipid and atherosclerosis +1 more
		HSPA5	Unknown	—	Disgenet	Protein export Protein processing in endoplasmic reticulum Antigen processing and presentation +12 more
		HSPE1-MOB4	Unknown	31835028	GWAS catalog	—
		HTR1A	Unknown	—	Disgenet	cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse +3 more
		HTR1B	Unknown	—	Disgenet	cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse +3 more
		HTR1E	Unknown	20889312	GWAS catalog	cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse +3 more
		HTR2A	Unknown	14708030	CTD, Disgenet	Calcium signaling pathway Neuroactive ligand-receptor interaction Gap junction +4 more
		HTR2C	Unknown	—	Disgenet	Calcium signaling pathway Neuroactive ligand-receptor interaction Gap junction +4 more
		HTR3A	Unknown	—	Disgenet	Serotonergic synapse Taste transduction Neurotransmitter receptors and postsynaptic signal transmission
		HTR3B	Unknown	—	Disgenet	Serotonergic synapse Taste transduction Neurotransmitter receptors and postsynaptic signal transmission
		HTR4	Unknown	—	Disgenet	Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction +4 more
		HTR5A	Unknown	—	Disgenet	Calcium signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse +2 more
		HTR6	Unknown	34002096	GWAS catalog	Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction +4 more
		HUWE1	Unknown	31043756	GWAS catalog	Ubiquitin mediated proteolysis Mitophagy - animal Neutrophil degranulation +1 more
		HYCC1	Unknown	21254220	GWAS catalog	—
		IDO2	Unknown	34099189	GWAS catalog	Tryptophan metabolism Metabolic pathways Biosynthesis of cofactors +2 more
		IFI44	Unknown	21926972 22182935 23453885 24280982 27890468 31043756	GWAS catalog	—
		IFNA1	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway Necroptosis +26 more
		IFNG	Unknown	—	Disgenet	Proteasome Cytokine-cytokine receptor interaction HIF-1 signaling pathway +33 more
		IFT27	Unknown	—	Disgenet	Intraflagellar transport
		IFT81	Unknown	31043756 34002096	GWAS catalog	Intraflagellar transport
		IFT88	Unknown	20713499	GWAS catalog	Hedgehog 'off' state Intraflagellar transport Aggrephagy
		IGF1	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +35 more
		IGFBP2	Unknown	—	Disgenet	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
		IGSF11	Unknown	23218918	GWAS catalog	Cell adhesion molecules
		IGSF9B	Unknown	28115744 31835028	GWAS catalog	—
		IL1B	Unknown	—	Disgenet	Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +47 more
		IL1R1	Unknown	23453885	GWAS catalog	MAPK signaling pathway Cytokine-cytokine receptor interaction NF-kappa B signaling pathway +12 more
		IL1R2	Unknown	23453885	GWAS catalog	Cytokine-cytokine receptor interaction Hematopoietic cell lineage Amoebiasis +6 more
		IL1RN	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Interleukin-10 signaling Interleukin-1 signaling
		IL2	Unknown	31043756 33686288 38858783	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor PI3K-Akt signaling pathway +21 more
		IL21	Unknown	31043756 33686288 38858783	GWAS catalog	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +2 more
		IL2RB	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Endocytosis +12 more
		IL6	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance Antifolate resistance Cytokine-cytokine receptor interaction +59 more
		ILF3	Unknown	34002096	GWAS catalog	—
		ILRUN	Unknown	31754094	GWAS catalog	—
		IMMP2L	Unknown	23453885 31043756 31835028 32606422 33479212	GWAS catalog	Protein export
		IMPA1	Unknown	—	Disgenet	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system +1 more
		IMPA2	Unknown	—	Disgenet	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system +1 more
		IMPACT	Unknown	—	Disgenet	—
		INAVA	Unknown	38154582	GWAS catalog	—
		INPP1	Unknown	—	Disgenet	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system +1 more
		INPP4A	Unknown	23092984	GWAS catalog	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system +3 more
		INS	Unknown	5506046	CTD, Disgenet	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +39 more
		INSC	Unknown	31043756	GWAS catalog	—
		INSYN1	Unknown	21738484 31043756	GWAS catalog	—
BIPOLAR I DISORDER	EFO_0009963	HTR6	Unknown	34002096	GWAS catalog	Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction +4 more
		IFT81	Unknown	34002096	GWAS catalog	Intraflagellar transport
		IL2	Unknown	31043756	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor PI3K-Akt signaling pathway +21 more
		IL21	Unknown	31043756	GWAS catalog	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +2 more
		ILF3	Unknown	34002096	GWAS catalog	—
		IMMP2L	Unknown	31043756	GWAS catalog	Protein export
BIPOLAR I DISORDER, MOST RECENT EPISODE MANIC	C0024713	HTR2A	Unknown	—	Disgenet	Calcium signaling pathway Neuroactive ligand-receptor interaction Gap junction +4 more
		HTR2C	Unknown	—	Disgenet	Calcium signaling pathway Neuroactive ligand-receptor interaction Gap junction +4 more
		IMPA2	Unknown	—	Disgenet	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system +1 more
		INS	Unknown	—	Disgenet	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +39 more
MIXED BIPOLAR I DISORDER	C0236780	HTR2A	Unknown	—	Disgenet	Calcium signaling pathway Neuroactive ligand-receptor interaction Gap junction +4 more
		HTR2C	Unknown	—	Disgenet	Calcium signaling pathway Neuroactive ligand-receptor interaction Gap junction +4 more
		IMPA2	Unknown	—	Disgenet	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system +1 more
		INS	Unknown	—	Disgenet	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +39 more

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Bipolar disorder

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