Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
BIPOLAR DISORDER	C0005586 MONDO_0004985 MESH:D001714	GRM3	Unknown	31835028 32606422 33479212	Disgenet, GWAS catalog	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +3 more
		GRM4	Unknown	—	Disgenet	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +3 more
		GRM5	Unknown	31926635 33479212	Disgenet, GWAS catalog	Calcium signaling pathway Phospholipase D signaling pathway Neuroactive ligand-receptor interaction +10 more
		GRM7	Unknown	—	Disgenet	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +2 more
		GRM8	Unknown	24322204	GWAS catalog	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +2 more
		GRN	Unknown	—	Disgenet	Neutrophil degranulation
		GSDMA	Unknown	34002096	GWAS catalog	—
		GSDME	Unknown	31043756 31835028 31926635 32606422 33479212 34159505	GWAS catalog	Cytosolic DNA-sensing pathway
		GSK3A	Unknown	20357757	CTD, Disgenet	Chemokine signaling pathway Dopaminergic synapse Non-alcoholic fatty liver disease +4 more
		GSK3B	Unknown	20357757	CTD, Disgenet	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Chemokine signaling pathway +59 more
		GSN	Unknown	20889312	GWAS catalog	Fc gamma R-mediated phagocytosis Regulation of actin cytoskeleton Viral carcinogenesis +3 more
		GSTM1	Unknown	—	Disgenet	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +10 more
		GSTM4	Unknown	30217971	GWAS catalog	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +11 more
		GSTT1	Unknown	—	Disgenet	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +10 more
		GSTZ1	Unknown	—	Disgenet	Tyrosine metabolism Metabolic pathways Glutathione conjugation +2 more
		H1-2	Unknown	34159505	GWAS catalog	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
		H2AC14	Unknown	38154582	GWAS catalog	ATP-dependent chromatin remodeling Necroptosis Neutrophil extracellular trap formation +30 more
		H2AC15	Unknown	32606422	GWAS catalog	ATP-dependent chromatin remodeling Necroptosis Neutrophil extracellular trap formation +10 more
		H2BC4	Unknown	34159505	GWAS catalog	Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis +31 more
		H2BC6	Unknown	38154582	GWAS catalog	Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis +31 more
		H2BC9	Unknown	34002096	GWAS catalog	Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis +31 more
		H3C8	Unknown	34002096	GWAS catalog	Neutrophil extracellular trap formation Alcoholism Shigellosis +27 more
		HACE1	Unknown	20889312	GWAS catalog	Antigen processing: Ubiquitination & Proteasome degradation
		HAPSTR1	Unknown	33169155 34002096 38154582	GWAS catalog	—
		HAPSTR2	Unknown	20889312	GWAS catalog	—
		HAX1	Unknown	31043756	GWAS catalog	—
		HCAR3	Unknown	—	Disgenet	cAMP signaling pathway Hydroxycarboxylic acid-binding receptors G alpha (i) signalling events
		HCN1	Unknown	31835028	GWAS catalog	GnRH secretion HCN channels
		HDAC4	Unknown	23453885	GWAS catalog	Apelin signaling pathway Neutrophil extracellular trap formation Alcoholism +8 more
		HDAC5	Unknown	31043756 33263727 34002096	CTD, Disgenet, GWAS catalog	Apelin signaling pathway Neutrophil extracellular trap formation Alcoholism +5 more
		HDAC7	Unknown	31043756 38858783	GWAS catalog	Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis +4 more
		HIF1A	Unknown	—	Disgenet	HIF-1 signaling pathway Mitophagy - animal Autophagy - animal +19 more
		HINT1	Unknown	23453885	Disgenet, GWAS catalog	—
		HIP1R	Unknown	—	Disgenet	Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
		HIVEP2	Unknown	31043756	GWAS catalog	—
		HLA-B	Unknown	21254220	GWAS catalog	Endocytosis Phagosome Cellular senescence +24 more
		HLA-DMA	Unknown	23453885 29121268 38154582	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +21 more
		HLA-DMB	Unknown	23453885 38154582	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +22 more
		HLA-DOB	Unknown	38154582	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +22 more
		HLA-DQB2	Unknown	38154582	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQB3	Unknown	23453885	GWAS catalog	—
		HLA-DRB1	Unknown	—	Disgenet	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DRB4	Unknown	—	Disgenet	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-E	Unknown	—	Disgenet	Endocytosis Phagosome Cellular senescence +24 more
		HLA-G	Unknown	—	Disgenet	Endocytosis Phagosome Cellular senescence +22 more
		HLCS	Unknown	30217971	GWAS catalog	Biotin metabolism Metabolic pathways Biotin transport and metabolism +1 more
		HLF	Unknown	31043756 33263727	GWAS catalog	—
		HMGXB4	Unknown	—	Disgenet	—
		HMHB1	Unknown	24322204	GWAS catalog	—
		HNF1B	Unknown	20889312	GWAS catalog	Maturity onset diabetes of the young
BIPOLAR I DISORDER	EFO_0009963	H2BC9	Unknown	34002096	GWAS catalog	Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis +31 more
		H3C8	Unknown	34002096	GWAS catalog	Neutrophil extracellular trap formation Alcoholism Shigellosis +27 more
		HDAC5	Unknown	34002096	GWAS catalog	Apelin signaling pathway Neutrophil extracellular trap formation Alcoholism +5 more
BIPOLAR I DISORDER, MOST RECENT EPISODE MANIC	C0024713	GSK3A	Unknown	—	Disgenet	Chemokine signaling pathway Dopaminergic synapse Non-alcoholic fatty liver disease +4 more
		GSK3B	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Chemokine signaling pathway +59 more
		HDAC5	Unknown	—	Disgenet	Apelin signaling pathway Neutrophil extracellular trap formation Alcoholism +5 more
MIXED BIPOLAR I DISORDER	C0236780	GSK3A	Unknown	—	Disgenet	Chemokine signaling pathway Dopaminergic synapse Non-alcoholic fatty liver disease +4 more
		GSK3B	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Chemokine signaling pathway +59 more
		HDAC5	Unknown	—	Disgenet	Apelin signaling pathway Neutrophil extracellular trap formation Alcoholism +5 more

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