Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
BIPOLAR DISORDER	C0005586 MONDO_0004985 MESH:D001714	ERVW-1	Unknown	—	Disgenet	—
		ESR1	Unknown	—	Disgenet	Endocrine resistance Hormone signaling Estrogen signaling pathway +21 more
		ESR2	Unknown	31835028 31926635	GWAS catalog	Endocrine resistance Hormone signaling Estrogen signaling pathway +11 more
		ETV5	Unknown	31754094	GWAS catalog	Transcriptional misregulation in cancer Prostate cancer
		F9	Unknown	—	Disgenet	Complement and coagulation cascades Extrinsic Pathway of Fibrin Clot Formation Intrinsic Pathway of Fibrin Clot Formation +3 more
		FAAH	Unknown	34099189	GWAS catalog	Retrograde endocannabinoid signaling Arachidonic acid metabolism
		FABP7	Unknown	—	Disgenet	PPAR signaling pathway Triglyceride catabolism
		FADS1	Unknown	28115744 31043756 38154582 38858783	GWAS catalog	Biosynthesis of unsaturated fatty acids Metabolic pathways Fatty acid metabolism +3 more
		FADS2	Unknown	28115744 31043756 31835028 34002096 38154582 38858783	CTD, Disgenet, GWAS catalog	alpha-Linolenic acid metabolism Biosynthesis of unsaturated fatty acids Metabolic pathways +4 more
		FAM177A1	Unknown	29121268	GWAS catalog	—
		FAM178B	Unknown	29121268	GWAS catalog	—
		FAM81A	Unknown	20889312	GWAS catalog	—
		FAT4	Unknown	20351715	GWAS catalog	Hippo signaling pathway - multiple species
		FBXL17	Unknown	24322204	GWAS catalog	—
		FBXL3	Unknown	—	Disgenet	Circadian rhythm Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		FBXO11	Unknown	34099189	GWAS catalog	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		FBXO28	Unknown	34099189	GWAS catalog	—
		FEZ1	Unknown	23453885	GWAS catalog	Viral life cycle - HIV-1
		FFAR2	Unknown	22925353	GWAS catalog	cAMP signaling pathway G alpha (q) signalling events Free fatty acid receptors
		FGF12	Unknown	31043756	GWAS catalog	Phase 0 - rapid depolarisation
		FGF17	Unknown	—	Disgenet	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +47 more
		FGF20	Unknown	—	Disgenet	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +46 more
		FGFR1	Unknown	31835028 32606422 33479212 34159505	Disgenet, GWAS catalog	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +32 more
		FGFR2	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +26 more
		FGGY	Unknown	30217971	GWAS catalog	Pentose and glucuronate interconversions Metabolic pathways
		FHIT	Unknown	34099189	GWAS catalog	Purine metabolism Metabolic pathways Small cell lung cancer +1 more
		FHL2	Unknown	34099189	GWAS catalog	Osteoclast differentiation Cytoskeleton in muscle cells PPARA activates gene expression
		FKBP2	Unknown	34002096	GWAS catalog	—
		FKBP5	Unknown	—	Disgenet	Estrogen signaling pathway HSP90 chaperone cycle for steroid hormone receptors (SHR) ESR-mediated signaling
		FOXN2	Unknown	23453885	GWAS catalog	—
		FOXO6	Unknown	21926972	GWAS catalog	FoxO signaling pathway Shigellosis
		FOXP2	Unknown	34099189	GWAS catalog	—
		FOXP3	Unknown	—	Disgenet	Th17 cell differentiation Inflammatory bowel disease RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) +1 more
		FOXQ1	Unknown	30217971	GWAS catalog	—
		FSTL5	Unknown	31043756 33686288	CTD, Disgenet, GWAS catalog	—
		FTCDNL1	Unknown	31835028 32606422 34159505	GWAS catalog	—
		FTH1	Unknown	34099189	GWAS catalog	Porphyrin metabolism Ferroptosis Necroptosis +4 more
		FTO	Unknown	34099189	GWAS catalog	Reversal of alkylation damage by DNA dioxygenases
		FURIN	Unknown	31835028 32606422 33479212 34002096 34159505	GWAS catalog	Viral life cycle - HIV-1 Collagen degradation Elastic fibre formation +12 more
		FXR1	Unknown	26433762	GWAS catalog	Signaling by BRAF and RAF fusions
		FYN	Unknown	31043756	Disgenet, GWAS catalog	Sphingolipid signaling pathway Phospholipase D signaling pathway Axon guidance +47 more
		FZD4	Unknown	—	Disgenet	mTOR signaling pathway Wnt signaling pathway Hippo signaling pathway +19 more
		G6PD	Unknown	—	Disgenet	Pentose phosphate pathway Glutathione metabolism Metabolic pathways +5 more
		GABRA1	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Retrograde endocannabinoid signaling GABAergic synapse +4 more
		GABRA3	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Retrograde endocannabinoid signaling GABAergic synapse +4 more
		GABRA5	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Retrograde endocannabinoid signaling GABAergic synapse +4 more
		GABRB1	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Retrograde endocannabinoid signaling Serotonergic synapse +4 more
		GABRB2	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Retrograde endocannabinoid signaling Serotonergic synapse +4 more
		GABRB3	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Retrograde endocannabinoid signaling Serotonergic synapse +4 more
		GABRG1	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Retrograde endocannabinoid signaling GABAergic synapse +2 more
BIPOLAR I DISORDER	EFO_0009963	FADS1	Unknown	31043756	GWAS catalog	Biosynthesis of unsaturated fatty acids Metabolic pathways Fatty acid metabolism +3 more
		FADS2	Unknown	31043756 34002096	GWAS catalog	alpha-Linolenic acid metabolism Biosynthesis of unsaturated fatty acids Metabolic pathways +4 more
		FSTL5	Unknown	31043756	GWAS catalog	—
BIPOLAR I DISORDER, MOST RECENT EPISODE MANIC	C0024713	FADS2	Unknown	—	Disgenet	alpha-Linolenic acid metabolism Biosynthesis of unsaturated fatty acids Metabolic pathways +4 more
		FSTL5	Unknown	—	Disgenet	—
		GABRA3	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Retrograde endocannabinoid signaling GABAergic synapse +4 more
		GABRA5	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Retrograde endocannabinoid signaling GABAergic synapse +4 more
MIXED BIPOLAR I DISORDER	C0236780	FADS2	Unknown	—	Disgenet	alpha-Linolenic acid metabolism Biosynthesis of unsaturated fatty acids Metabolic pathways +4 more
		FSTL5	Unknown	—	Disgenet	—
		GABRA3	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Retrograde endocannabinoid signaling GABAergic synapse +4 more
		GABRA5	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Retrograde endocannabinoid signaling GABAergic synapse +4 more

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Bipolar disorder

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