Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
BIPOLAR DISORDER	C0005586 MONDO_0004985 MESH:D001714	ME2	Unknown	—	Disgenet	Pyruvate metabolism Carbon metabolism Citric acid cycle (TCA cycle)
		METTL15	Unknown	33479212	GWAS catalog	—
		METTL9	Unknown	34099189	GWAS catalog	—
		MFGE8	Unknown	—	Disgenet	Efferocytosis Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation +1 more
		MGAT4A	Unknown	21738484	GWAS catalog	N-Glycan biosynthesis Various types of N-glycan biosynthesis Metabolic pathways +3 more
		MGLL	Unknown	39024449	GWAS catalog	Glycerolipid metabolism Metabolic pathways Thermogenesis +4 more
		MINDY2	Unknown	34099189	GWAS catalog	—
		MKLN1	Unknown	27769005	GWAS catalog	—
		MLC1	Unknown	—	Disgenet	—
		MLLT3	Unknown	—	Disgenet	Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex +2 more
		MMP10	Unknown	—	Disgenet	Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases
		MMP16	Unknown	31043756	GWAS catalog	Parathyroid hormone synthesis, secretion and action MicroRNAs in cancer Activation of Matrix Metalloproteinases
		MMP9	Unknown	—	Disgenet	Endocrine resistance IL-17 signaling pathway TNF signaling pathway +22 more
		MOB4	Unknown	31835028	GWAS catalog	—
		MOCOS	Unknown	34099189	GWAS catalog	Folate biosynthesis Metabolic pathways Molybdenum cofactor biosynthesis
		MOCS3	Unknown	33169155	GWAS catalog	Sulfur relay system Molybdenum cofactor biosynthesis
		MOG	Unknown	38154582	GWAS catalog	—
		MPHOSPH9	Unknown	31835028	GWAS catalog	—
		MPPE1	Unknown	—	Disgenet	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Metabolic pathways
		MRM2	Unknown	23453885	GWAS catalog	rRNA modification in the mitochondrion
		MRPL33	Unknown	31043756 31835028 32606422 33479212 34159505 38154582 38858783	GWAS catalog	Ribosome Mitochondrial translation elongation Mitochondrial translation termination
		MRPS33	Unknown	31043756	CTD, Disgenet	Mitochondrial translation elongation Mitochondrial translation termination
		MRTFA	Unknown	20889312	GWAS catalog	SUMOylation of transcription cofactors RHO GTPases Activate Formins
		MSRA	Unknown	22688191 31043756 34002096 38154582	GWAS catalog	Protein repair
		MTHFD1	Unknown	—	Disgenet	One carbon pool by folate Metabolic pathways Biosynthesis of cofactors +2 more
		MTHFR	Unknown	17074966	CTD, Disgenet	One carbon pool by folate Metabolic pathways Antifolate resistance +2 more
		MTR	Unknown	—	Disgenet	Cysteine and methionine metabolism Selenocompound metabolism One carbon pool by folate +9 more
		MUC1	Unknown	38858783	GWAS catalog	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +4 more
		MUC21	Unknown	38154582	GWAS catalog	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUCL3	Unknown	23453885	GWAS catalog	—
		MUSTN1	Unknown	38858783	GWAS catalog	—
		MVB12B	Unknown	31043756	GWAS catalog	Endocytosis Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins +2 more
		MXI1	Unknown	32606422	GWAS catalog	—
		MYH15	Unknown	31926635	GWAS catalog	Motor proteins Cytoskeleton in muscle cells
		MYL12BP2	Unknown	34099189	GWAS catalog	—
		MYO16	Unknown	31043756	GWAS catalog	Motor proteins
		MYO18A	Unknown	31835028	GWAS catalog	Motor proteins Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease
		MYO18B	Unknown	20713499	GWAS catalog	Motor proteins
		MYO19	Unknown	34002096	GWAS catalog	Motor proteins
		MYO1G	Unknown	31043756 33686288	GWAS catalog	Motor proteins Pathogenic Escherichia coli infection
		MYO1H	Unknown	29121268	GWAS catalog	Motor proteins Pathogenic Escherichia coli infection
		MYOM2	Unknown	20889312	GWAS catalog	Cytoskeleton in muscle cells
		MYOM3	Unknown	23092984	GWAS catalog	Cytoskeleton in muscle cells
		MYRF	Unknown	38154582	GWAS catalog	—
		NAA11	Unknown	31835028	GWAS catalog	—
		NAA40	Unknown	31835028 34159505	GWAS catalog	—
		NAALADL2	Unknown	24322204	GWAS catalog	—
		NALCN	Unknown	20889312 26433762	GWAS catalog	Stimuli-sensing channels
		NALF1	Unknown	23453885	GWAS catalog	—
		NAPG	Unknown	—	Disgenet	COPII-mediated vesicle transport COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic +2 more
BIPOLAR I DISORDER	EFO_0009963	MRPL33	Unknown	31043756	GWAS catalog	Ribosome Mitochondrial translation elongation Mitochondrial translation termination
		MYO16	Unknown	31043756	GWAS catalog	Motor proteins
		MYO19	Unknown	34002096	GWAS catalog	Motor proteins
		MYO1G	Unknown	31043756	GWAS catalog	Motor proteins Pathogenic Escherichia coli infection
BIPOLAR I DISORDER, MOST RECENT EPISODE MANIC	C0024713	ME2	Unknown	—	Disgenet	Pyruvate metabolism Carbon metabolism Citric acid cycle (TCA cycle)
		MRPS33	Unknown	—	Disgenet	Mitochondrial translation elongation Mitochondrial translation termination
		MTHFR	Unknown	—	Disgenet	One carbon pool by folate Metabolic pathways Antifolate resistance +2 more
MIXED BIPOLAR I DISORDER	C0236780	MRPS33	Unknown	—	Disgenet	Mitochondrial translation elongation Mitochondrial translation termination
MIXED BIPOLAR I DISORDER	C0236780	MTHFR	Unknown	—	Disgenet	One carbon pool by folate Metabolic pathways Antifolate resistance +2 more

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Bipolar disorder

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