Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 202

8 diseases · 19 shared-gene connections
8 Diseases
22 Unique genes
0.252 Avg. similarity score
Hyper-ige syndrome Most-connected disease (6 links)
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Disease Searched: multisystemic smooth muscle dysfunction syndrome Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Hyper-ige syndrome 6 6 1
Lymphoproliferative disorder of natural killer cells 6 6 1
STAT3-related early-onset multisystem autoimmune disease 6 6 1
hyper-IgE recurrent infection syndrome 1, autosomal dominant 6 6 1
Copper overload cirrhosis 5 5 11
Atrophy 4 4 10
Hyper-immunoglobulin e syndrome 4 4 3
multisystemic smooth muscle dysfunction syndrome 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
STAT3 7 / 8 Atrophy, Copper overload cirrhosis, hyper-IgE recurrent infection syndrome 1, autosomal dominant, Hyper-ige syndrome and 3 more
ACTA2 2 / 8 Copper overload cirrhosis, multisystemic smooth muscle dysfunction syndrome
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Proteoglycans in cancer
MAPK3, RPS6KB1, STAT3, CASP3, HGF, MET, SMAD2, TGFB1, ITGB3
 KEGG 9 / 204 24.1× 4.05e-11 6.04e-9 ✓ sig.
MET activates STAT3
STAT3, HGF, MET
 Reactome 3 / 3 546× 5.34e-9 4.84e-7 ✓ sig.
Th17 cell differentiation
AHR, MAPK3, STAT3, SMAD2, TGFB1, IL6ST
 KEGG 6 / 109 30.1× 3.23e-8 2.40e-6 ✓ sig.
Pathways in cancer
MAPK3, RPS6KB1, STAT3, CASP3, HGF, MET, SMAD2, TGFB1, IL6ST
 KEGG 9 / 533 9.2× 1.85e-7 1.12e-5 ✓ sig.
Gastric cancer
MAPK3, RPS6KB1, HGF, MET, SMAD2, TGFB1
 KEGG 6 / 150 21.8× 2.17e-7 1.28e-5 ✓ sig.
Pancreatic cancer
MAPK3, RPS6KB1, STAT3, SMAD2, TGFB1
 KEGG 5 / 77 35.4× 2.30e-7 1.35e-5 ✓ sig.
EGFR tyrosine kinase inhibitor resistance
MAPK3, RPS6KB1, STAT3, HGF, MET
 KEGG 5 / 80 34.1× 2.78e-7 1.60e-5 ✓ sig.
Colorectal cancer
MAPK3, RPS6KB1, CASP3, SMAD2, TGFB1
 KEGG 5 / 87 31.4× 4.24e-7 2.32e-5 ✓ sig.
Hepatocellular carcinoma
MAPK3, RPS6KB1, HGF, MET, SMAD2, TGFB1
 KEGG 6 / 170 19.3× 4.55e-7 2.47e-5 ✓ sig.
AGE-RAGE signaling pathway in diabetic complications
MAPK3, STAT3, CASP3, SMAD2, TGFB1
 KEGG 5 / 101 27.0× 8.95e-7 4.41e-5 ✓ sig.
Renal cell carcinoma
MAPK3, HGF, MET, TGFB1
 KEGG 4 / 70 31.2× 7.15e-6 2.60e-4 ✓ sig.
Non-small cell lung cancer
MAPK3, STAT3, HGF, MET
 KEGG 4 / 73 29.9× 8.46e-6 2.99e-4 ✓ sig.
MET activates PTPN11
HGF, MET
 Reactome 2 / 5 218× 3.19e-5 8.92e-4 ✓ sig.
MET interacts with TNS proteins
HGF, MET
 Reactome 2 / 5 218× 3.19e-5 8.92e-4 ✓ sig.
Chemical carcinogenesis - receptor activation
AHR, CYP1A2, MAPK3, RPS6KB1, STAT3
 KEGG 5 / 215 12.7× 3.61e-5 9.87e-4 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
negative regulation of autophagy
MAPK3, RPS6KB1, STAT3, HGF, MET
 GO:0010507 5 / 73 58.2× 1.98e-8 3.06e-6 ✓ sig.
positive regulation of vascular endothelial growth factor production
STAT3, TGFB1, IL6ST
 GO:0010575 3 / 32 79.6× 6.87e-6 3.95e-4 ✓ sig.
positive regulation of gene expression
CLU, STAT3, ACTA2, SMAD2, TGFB1, ITGB3
 GO:0010628 6 / 504 10.1× 1.93e-5 8.86e-4 ✓ sig.
response to anesthetic
SLC1A1, CASP3
 GO:0072347 2 / 6 283× 1.98e-5 9.05e-4 ✓ sig.
negative regulation of hydrogen peroxide-mediated programmed cell death
HGF, MET
 GO:1901299 2 / 6 283× 1.98e-5 9.05e-4 ✓ sig.
interleukin-11-mediated signaling pathway
STAT3, IL6ST
 GO:0038154 2 / 7 243× 2.77e-5 1.16e-3 ✓ sig.
response to glucocorticoid
IL1RN, TRIM63, CASP3
 GO:0051384 3 / 53 48.1× 3.19e-5 1.30e-3 ✓ sig.
odontoblast differentiation
SMAD2, TGFB1
 GO:0071895 2 / 8 212× 3.69e-5 1.46e-3 ✓ sig.
hepatocyte growth factor receptor signaling pathway
HGF, MET
 GO:0048012 2 / 8 212× 3.69e-5 1.46e-3 ✓ sig.
response to cholesterol
SMAD2, TGFB1
 GO:0070723 2 / 10 170× 5.92e-5 2.08e-3 ✓ sig.
response to glucose
CASP3, SMAD2, TGFB1
 GO:0009749 3 / 68 37.5× 6.75e-5 2.30e-3 ✓ sig.
negative regulation of T cell mediated immune response to tumor cell
AHR, MAPK3
 GO:0002841 2 / 11 154× 7.23e-5 2.43e-3 ✓ sig.
positive regulation of ERK1 and ERK2 cascade
MAPK3, ACTA2, TGFB1, ITGB3
 GO:0070374 4 / 201 16.9× 8.16e-5 2.66e-3 ✓ sig.
cellular response to insulin-like growth factor stimulus
TGFB1, ITGB3
 GO:1990314 2 / 12 142× 8.67e-5 2.78e-3 ✓ sig.
regulation of gene expression
AHR, CYP1A2, MAPK3, MET, TGFB1
 GO:0010468 5 / 402 10.6× 8.75e-5 2.80e-3 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Lymphoproliferative disorder of natural killer cells STAT3-related early-onset multisystem autoimmune disease 0.500 1 6.49e-5 2.32e-4 ✓ sig.
Hyper-ige syndrome STAT3-related early-onset multisystem autoimmune disease 0.500 1 6.49e-5 2.32e-4 ✓ sig.
Hyper-ige syndrome Lymphoproliferative disorder of natural killer cells 0.500 1 6.49e-5 2.32e-4 ✓ sig.
hyper-IgE recurrent infection syndrome 1, autosomal dominant Hyper-ige syndrome 0.500 1 6.49e-5 2.32e-4 ✓ sig.
hyper-IgE recurrent infection syndrome 1, autosomal dominant Lymphoproliferative disorder of natural killer cells 0.500 1 6.49e-5 2.32e-4 ✓ sig.
hyper-IgE recurrent infection syndrome 1, autosomal dominant STAT3-related early-onset multisystem autoimmune disease 0.500 1 6.49e-5 2.32e-4 ✓ sig.
Hyper-immunoglobulin e syndrome STAT3-related early-onset multisystem autoimmune disease 0.250 1 1.95e-4 5.32e-4 ✓ sig.
Hyper-immunoglobulin e syndrome Lymphoproliferative disorder of natural killer cells 0.250 1 1.95e-4 5.32e-4 ✓ sig.
Hyper-ige syndrome Hyper-immunoglobulin e syndrome 0.250 1 1.95e-4 5.32e-4 ✓ sig.
hyper-IgE recurrent infection syndrome 1, autosomal dominant Hyper-immunoglobulin e syndrome 0.250 1 1.95e-4 5.32e-4 ✓ sig.
Atrophy Lymphoproliferative disorder of natural killer cells 0.091 1 6.49e-4 1.24e-3 ✓ sig.
Atrophy hyper-IgE recurrent infection syndrome 1, autosomal dominant 0.091 1 6.49e-4 1.24e-3 ✓ sig.
Atrophy STAT3-related early-onset multisystem autoimmune disease 0.091 1 6.49e-4 1.24e-3 ✓ sig.
Atrophy Hyper-ige syndrome 0.091 1 6.49e-4 1.24e-3 ✓ sig.
Copper overload cirrhosis hyper-IgE recurrent infection syndrome 1, autosomal dominant 0.083 1 7.14e-4 1.33e-3 ✓ sig.
Copper overload cirrhosis STAT3-related early-onset multisystem autoimmune disease 0.083 1 7.14e-4 1.33e-3 ✓ sig.
Copper overload cirrhosis Lymphoproliferative disorder of natural killer cells 0.083 1 7.14e-4 1.33e-3 ✓ sig.
Copper overload cirrhosis Hyper-ige syndrome 0.083 1 7.14e-4 1.33e-3 ✓ sig.
Copper overload cirrhosis multisystemic smooth muscle dysfunction syndrome 0.083 1 7.14e-4 1.33e-3 ✓ sig.