Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 11

28 diseases · 104 shared-gene connections
28 Diseases
35 Unique genes
0.364 Avg. similarity score
Endometrial cyst Most-connected disease (23 links)
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Disease Searched: Endometrial cyst Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Endometrial cyst 23 23 1
Low grade vulvar intraepithelial neoplasia 23 23 1
PTEN hamartoma tumor syndrome 23 23 1
Atypical ductal hyperplasia 21 21 3
Cervical endometrioid adenocarcinoma 19 19 3
Anisometropia 6 6 2
Lipomatosis 6 6 2
Atrophy 5 5 11
Bannayan-riley-ruvalcaba syndrome 5 5 1
Breast and ovarian cancer 5 5 3
Concussion 5 5 4
Cowden syndrome 1 5 5 1
Extragonadal germ cell cancer 5 5 6
Gangliocytoma 5 5 2
Glioma susceptibility 2 5 5 1
Lacrimal duct cancer 5 5 2
Lhermitte-duclos disease 5 5 1
Malignant melanoma, somatic 5 5 1
Primary effusion lymphoma 5 5 3
Proteus syndrome 5 5 2
Squamous cell carcinoma, head and neck, somatic 5 5 1
Vater association with macrocephaly and ventriculomegaly 5 5 1
Calcifying epithelial odontogenic tumor 4 4 4
Papillary tumor of the pineal region 4 4 4
Ceroid lipofuscinosis, neuronal, 4a (kufs type), autosomal recessive 1 1 1
Dicarboxylic aminoaciduria 1 1 1
Maturity-onset diabetes of the young type 8 1 1 1
Trichiasis 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
PTEN 24 / 28 Anisometropia, Atrophy, Atypical ductal hyperplasia, Bannayan-riley-ruvalcaba syndrome and 20 more
CDKN2A 2 / 28 Calcifying epithelial odontogenic tumor, Primary effusion lymphoma
CEL 2 / 28 Lipomatosis, Maturity-onset diabetes of the young type 8
CLN6 2 / 28 Atrophy, Ceroid lipofuscinosis, neuronal, 4a (kufs type), autosomal recessive
KRAS 2 / 28 Atypical ductal hyperplasia, Cervical endometrioid adenocarcinoma
MCM7 2 / 28 Anisometropia, Trichiasis
SLC1A1 2 / 28 Atrophy, Dicarboxylic aminoaciduria
TP53 2 / 28 Cervical endometrioid adenocarcinoma, Papillary tumor of the pineal region
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Non-small cell lung cancer
MAPK3, STAT3, TP53, CDKN2A, AKT1, PIK3CA, PIK3R2, KRAS, MET, JAK3, NRAS
 KEGG 11 / 73 51.7× 7.08e-17 3.07e-14 ✓ sig.
Central carbon metabolism in cancer
PTEN, MAPK3, TP53, IDH1, AKT1, PIK3CA, PIK3R2, KRAS, MET, NRAS
 KEGG 10 / 71 48.3× 4.40e-15 1.35e-12 ✓ sig.
Melanoma
PTEN, MAPK3, TP53, CDKN2A, AKT1, PIK3CA, PIK3R2, KRAS, MET, NRAS
 KEGG 10 / 73 47.0× 5.90e-15 1.75e-12 ✓ sig.
EGFR tyrosine kinase inhibitor resistance
PTEN, MAPK3, RPS6KB1, STAT3, AKT1, PIK3CA, PIK3R2, KRAS, MET, NRAS
 KEGG 10 / 80 42.9× 1.54e-14 4.22e-12 ✓ sig.
Glioma
PTEN, MAPK3, TP53, CDKN2A, AKT1, PIK3CA, PIK3R2, KRAS, NRAS
 KEGG 9 / 76 40.6× 6.18e-13 1.24e-10 ✓ sig.
Pancreatic cancer
MAPK3, RPS6KB1, STAT3, TP53, CDKN2A, AKT1, PIK3CA, PIK3R2, KRAS
 KEGG 9 / 77 40.1× 6.98e-13 1.40e-10 ✓ sig.
Hepatocellular carcinoma
PTEN, MAPK3, RPS6KB1, TP53, CDKN2A, AKT1, PIK3CA, PIK3R2, KRAS, MET, NRAS
 KEGG 11 / 170 22.2× 1.03e-12 1.95e-10 ✓ sig.
PD-L1 expression and PD-1 checkpoint pathway in cancer
PTEN, MAPK3, RPS6KB1, STAT3, AKT1, PIK3CA, PIK3R2, KRAS, NRAS
 KEGG 9 / 90 34.3× 2.98e-12 5.08e-10 ✓ sig.
Endometrial cancer
PTEN, MAPK3, TP53, AKT1, PIK3CA, PIK3R2, KRAS, NRAS
 KEGG 8 / 59 46.5× 4.40e-12 7.24e-10 ✓ sig.
Endocrine resistance
MAPK3, RPS6KB1, TP53, CDKN2A, AKT1, PIK3CA, PIK3R2, KRAS, NRAS
 KEGG 9 / 99 31.2× 7.18e-12 1.13e-9 ✓ sig.
Proteoglycans in cancer
MAPK3, RPS6KB1, STAT3, TP53, AKT1, PIK3CA, RRAS2, PIK3R2, KRAS, MET, NRAS
 KEGG 11 / 204 18.5× 7.58e-12 1.18e-9 ✓ sig.
Acute myeloid leukemia
MAPK3, RPS6KB1, STAT3, AKT1, PIK3CA, PIK3R2, KRAS, NRAS
 KEGG 8 / 68 40.4× 1.44e-11 2.10e-9 ✓ sig.
Cellular senescence
PTEN, MAPK3, TP53, CDKN2A, AKT1, PIK3CA, RRAS2, PIK3R2, KRAS, NRAS
 KEGG 10 / 157 21.9× 1.51e-11 2.20e-9 ✓ sig.
Autophagy - animal
PTEN, MAPK3, RPS6KB1, AKT1, PIK3CA, RRAS2, PIK3R2, KRAS, NRAS, STK11
 KEGG 10 / 169 20.3× 3.16e-11 4.27e-9 ✓ sig.
Chronic myeloid leukemia
MAPK3, TP53, CDKN2A, AKT1, PIK3CA, PIK3R2, KRAS, NRAS
 KEGG 8 / 77 35.7× 4.03e-11 5.29e-9 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
phosphatidylinositol 3-kinase/protein kinase B signal transduction
PTEN, RPS6KB1, STAT3, AKT1, PIK3CA, PIK3R2
 GO:0043491 6 / 92 34.8× 1.75e-8 2.86e-6 ✓ sig.
negative regulation of autophagy
MAPK3, RPS6KB1, STAT3, AKT1, MET
 GO:0010507 5 / 73 36.6× 2.35e-7 2.58e-5 ✓ sig.
Ras protein signal transduction
TP53, CDKN2A, RRAS2, KRAS, NRAS
 GO:0007265 5 / 79 33.8× 3.49e-7 3.60e-5 ✓ sig.
insulin receptor signaling pathway
MAPK3, RPS6KB1, AKT1, PIK3CA, PIK3R2
 GO:0008286 5 / 80 33.4× 3.72e-7 3.79e-5 ✓ sig.
apoptotic process
PTEN, AHR, CLU, MAPK3, RPS6KB1, TP53, CDKN2A, AKT1, STK11, PALB2
 GO:0006915 10 / 747 7.1× 7.26e-7 6.60e-5 ✓ sig.
anoikis
AKT1, PIK3CA, STK11
 GO:0043276 3 / 12 133× 1.31e-6 1.07e-4 ✓ sig.
phosphorylation
MAPK3, STAT3, AKT1
 GO:0016310 3 / 14 114× 2.16e-6 1.61e-4 ✓ sig.
glucose homeostasis
MAPK3, STAT3, CDKN2A, AKT1, STK11
 GO:0042593 5 / 134 19.9× 4.80e-6 3.07e-4 ✓ sig.
cytokine-mediated signaling pathway
SLC1A1, STAT3, AKT1, KRAS, JAK3
 GO:0019221 5 / 145 18.4× 7.06e-6 4.15e-4 ✓ sig.
TORC1 signaling
MAPK3, RPS6KB1, AKT1, CARD11
 GO:0038202 4 / 67 31.9× 7.27e-6 4.25e-4 ✓ sig.
cell population proliferation
MCM7, STAT3, H3-3A, TP53, AKT1, KRAS
 GO:0008283 6 / 263 12.2× 8.46e-6 4.79e-4 ✓ sig.
negative regulation of TORC1 signaling
MAPK3, RPS6KB1, AKT1, STK11
 GO:1904262 4 / 71 30.1× 9.16e-6 5.09e-4 ✓ sig.
insulin-like growth factor receptor signaling pathway
MAPK3, AKT1, PIK3CA
 GO:0048009 3 / 33 48.5× 3.16e-5 1.30e-3 ✓ sig.
central nervous system myelin maintenance
PTEN, CLU
 GO:0032286 2 / 5 214× 3.40e-5 1.38e-3 ✓ sig.
positive regulation of gene expression
CLU, STAT3, TP53, CDKN2A, AKT1, PRDM1, KRAS
 GO:0010628 7 / 504 7.4× 3.48e-5 1.40e-3 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Calcifying epithelial odontogenic tumor Primary effusion lymphoma 0.333 2 1.50e-7 1.02e-6 ✓ sig.
Atypical ductal hyperplasia PTEN hamartoma tumor syndrome 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Atypical ductal hyperplasia Low grade vulvar intraepithelial neoplasia 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Atypical ductal hyperplasia Endometrial cyst 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Atypical ductal hyperplasia Cervical endometrioid adenocarcinoma 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Atypical ductal hyperplasia Lhermitte-duclos disease 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Bannayan-riley-ruvalcaba syndrome PTEN hamartoma tumor syndrome 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Bannayan-riley-ruvalcaba syndrome Low grade vulvar intraepithelial neoplasia 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Bannayan-riley-ruvalcaba syndrome Endometrial cyst 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Atypical ductal hyperplasia Bannayan-riley-ruvalcaba syndrome 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Bannayan-riley-ruvalcaba syndrome Cervical endometrioid adenocarcinoma 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Cervical endometrioid adenocarcinoma PTEN hamartoma tumor syndrome 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Cervical endometrioid adenocarcinoma Low grade vulvar intraepithelial neoplasia 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Cervical endometrioid adenocarcinoma Endometrial cyst 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Cervical endometrioid adenocarcinoma Lhermitte-duclos disease 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Cowden syndrome 1 PTEN hamartoma tumor syndrome 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Cowden syndrome 1 Low grade vulvar intraepithelial neoplasia 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Cowden syndrome 1 Endometrial cyst 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Atypical ductal hyperplasia Cowden syndrome 1 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Cervical endometrioid adenocarcinoma Cowden syndrome 1 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Endometrial cyst PTEN hamartoma tumor syndrome 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Endometrial cyst Low grade vulvar intraepithelial neoplasia 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Endometrial cyst Lhermitte-duclos disease 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Glioma susceptibility 2 PTEN hamartoma tumor syndrome 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Glioma susceptibility 2 Low grade vulvar intraepithelial neoplasia 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Endometrial cyst Glioma susceptibility 2 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Atypical ductal hyperplasia Glioma susceptibility 2 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Cervical endometrioid adenocarcinoma Glioma susceptibility 2 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Lhermitte-duclos disease PTEN hamartoma tumor syndrome 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Lhermitte-duclos disease Low grade vulvar intraepithelial neoplasia 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Low grade vulvar intraepithelial neoplasia PTEN hamartoma tumor syndrome 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Malignant melanoma, somatic PTEN hamartoma tumor syndrome 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Low grade vulvar intraepithelial neoplasia Malignant melanoma, somatic 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Endometrial cyst Malignant melanoma, somatic 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Atypical ductal hyperplasia Malignant melanoma, somatic 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Cervical endometrioid adenocarcinoma Malignant melanoma, somatic 0.500 1 6.46e-5 1.98e-4 ✓ sig.
PTEN hamartoma tumor syndrome Squamous cell carcinoma, head and neck, somatic 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Low grade vulvar intraepithelial neoplasia Squamous cell carcinoma, head and neck, somatic 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Endometrial cyst Squamous cell carcinoma, head and neck, somatic 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Atypical ductal hyperplasia Squamous cell carcinoma, head and neck, somatic 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Cervical endometrioid adenocarcinoma Squamous cell carcinoma, head and neck, somatic 0.500 1 6.46e-5 1.98e-4 ✓ sig.
PTEN hamartoma tumor syndrome Vater association with macrocephaly and ventriculomegaly 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Low grade vulvar intraepithelial neoplasia Vater association with macrocephaly and ventriculomegaly 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Endometrial cyst Vater association with macrocephaly and ventriculomegaly 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Atypical ductal hyperplasia Vater association with macrocephaly and ventriculomegaly 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Cervical endometrioid adenocarcinoma Vater association with macrocephaly and ventriculomegaly 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Anisometropia PTEN hamartoma tumor syndrome 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Anisometropia Low grade vulvar intraepithelial neoplasia 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Anisometropia Endometrial cyst 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Anisometropia Atypical ductal hyperplasia 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Anisometropia Cervical endometrioid adenocarcinoma 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Gangliocytoma PTEN hamartoma tumor syndrome 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Gangliocytoma Low grade vulvar intraepithelial neoplasia 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Endometrial cyst Gangliocytoma 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Atypical ductal hyperplasia Gangliocytoma 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Cervical endometrioid adenocarcinoma Gangliocytoma 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Lacrimal duct cancer PTEN hamartoma tumor syndrome 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Lacrimal duct cancer Low grade vulvar intraepithelial neoplasia 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Endometrial cyst Lacrimal duct cancer 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Atypical ductal hyperplasia Lacrimal duct cancer 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Cervical endometrioid adenocarcinoma Lacrimal duct cancer 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Lipomatosis PTEN hamartoma tumor syndrome 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Lipomatosis Low grade vulvar intraepithelial neoplasia 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Endometrial cyst Lipomatosis 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Atypical ductal hyperplasia Lipomatosis 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Cervical endometrioid adenocarcinoma Lipomatosis 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Lipomatosis Maturity-onset diabetes of the young type 8 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Proteus syndrome PTEN hamartoma tumor syndrome 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Low grade vulvar intraepithelial neoplasia Proteus syndrome 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Endometrial cyst Proteus syndrome 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Atypical ductal hyperplasia Proteus syndrome 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Cervical endometrioid adenocarcinoma Proteus syndrome 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Anisometropia Trichiasis 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Breast and ovarian cancer PTEN hamartoma tumor syndrome 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Breast and ovarian cancer Low grade vulvar intraepithelial neoplasia 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Breast and ovarian cancer Endometrial cyst 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Atypical ductal hyperplasia Breast and ovarian cancer 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Breast and ovarian cancer Cervical endometrioid adenocarcinoma 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Papillary tumor of the pineal region PTEN hamartoma tumor syndrome 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Low grade vulvar intraepithelial neoplasia Papillary tumor of the pineal region 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Endometrial cyst Papillary tumor of the pineal region 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Atypical ductal hyperplasia Papillary tumor of the pineal region 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Primary effusion lymphoma PTEN hamartoma tumor syndrome 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Low grade vulvar intraepithelial neoplasia Primary effusion lymphoma 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Endometrial cyst Primary effusion lymphoma 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Atypical ductal hyperplasia Primary effusion lymphoma 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Calcifying epithelial odontogenic tumor PTEN hamartoma tumor syndrome 0.200 1 2.58e-4 5.38e-4 ✓ sig.
Calcifying epithelial odontogenic tumor Low grade vulvar intraepithelial neoplasia 0.200 1 2.58e-4 5.38e-4 ✓ sig.
Calcifying epithelial odontogenic tumor Endometrial cyst 0.200 1 2.58e-4 5.38e-4 ✓ sig.
Concussion PTEN hamartoma tumor syndrome 0.200 1 2.58e-4 5.38e-4 ✓ sig.
Concussion Low grade vulvar intraepithelial neoplasia 0.200 1 2.58e-4 5.38e-4 ✓ sig.
Concussion Endometrial cyst 0.200 1 2.58e-4 5.38e-4 ✓ sig.
Atypical ductal hyperplasia Concussion 0.200 1 2.58e-4 5.38e-4 ✓ sig.
Cervical endometrioid adenocarcinoma Concussion 0.200 1 2.58e-4 5.38e-4 ✓ sig.
Extragonadal germ cell cancer PTEN hamartoma tumor syndrome 0.143 1 3.87e-4 7.33e-4 ✓ sig.
Extragonadal germ cell cancer Low grade vulvar intraepithelial neoplasia 0.143 1 3.87e-4 7.33e-4 ✓ sig.
Endometrial cyst Extragonadal germ cell cancer 0.143 1 3.87e-4 7.33e-4 ✓ sig.
Atypical ductal hyperplasia Extragonadal germ cell cancer 0.143 1 3.87e-4 7.33e-4 ✓ sig.
Cervical endometrioid adenocarcinoma Extragonadal germ cell cancer 0.143 1 3.87e-4 7.33e-4 ✓ sig.
Atrophy PTEN hamartoma tumor syndrome 0.083 1 7.10e-4 1.17e-3 ✓ sig.
Atrophy Low grade vulvar intraepithelial neoplasia 0.083 1 7.10e-4 1.17e-3 ✓ sig.
Atrophy Endometrial cyst 0.083 1 7.10e-4 1.17e-3 ✓ sig.
Atrophy Ceroid lipofuscinosis, neuronal, 4a (kufs type), autosomal recessive 0.083 1 7.10e-4 1.17e-3 ✓ sig.
Atrophy Dicarboxylic aminoaciduria 0.083 1 7.10e-4 1.17e-3 ✓ sig.