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Cluster 366

5 diseases · 6 shared-gene connections

5 Diseases

34 Unique genes

0.205 Avg. similarity score

C3 glomerulonephritis Most-connected disease (3 links)

Significant edges only (q < 0.05) Spacing Colour by

Disease Searched: C3 glomerulonephritis Pinned (dragged)

Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

C3 glomerulonephritis Hemolytic uremic syndrome Mesangiocapillary glomerulonephritis atypical hemolytic-uremic syndrome with B factor anomaly hemolytic uremic syndrome, atypical, 8, with rhizomelic short stature

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵	Connections in cluster ⇵	Significant partners ⇵	Curated genes ⇵
C3 glomerulonephritis	3	3	8
Hemolytic uremic syndrome	3	3	33
Mesangiocapillary glomerulonephritis	3	3	8
atypical hemolytic-uremic syndrome with B factor anomaly	2	2	1
hemolytic uremic syndrome, atypical, 8, with rhizomelic short stature	1	1	1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵	Member diseases ⇵	Linked diseases
CFB	4 / 5	atypical hemolytic-uremic syndrome with B factor anomaly, C3 glomerulonephritis, Hemolytic uremic syndrome, Mesangiocapillary glomerulonephritis
C3	3 / 5	C3 glomerulonephritis, Hemolytic uremic syndrome, Mesangiocapillary glomerulonephritis
CFH	3 / 5	C3 glomerulonephritis, Hemolytic uremic syndrome, Mesangiocapillary glomerulonephritis
CFHR1	3 / 5	C3 glomerulonephritis, Hemolytic uremic syndrome, Mesangiocapillary glomerulonephritis
CFHR5	3 / 5	C3 glomerulonephritis, Hemolytic uremic syndrome, Mesangiocapillary glomerulonephritis
CFI	3 / 5	C3 glomerulonephritis, Hemolytic uremic syndrome, Mesangiocapillary glomerulonephritis
C1GALT1C1	2 / 5	Hemolytic uremic syndrome, hemolytic uremic syndrome, atypical, 8, with rhizomelic short stature
CD46	2 / 5	Hemolytic uremic syndrome, Mesangiocapillary glomerulonephritis
CFHR3	2 / 5	C3 glomerulonephritis, Hemolytic uremic syndrome
DGKE	2 / 5	Hemolytic uremic syndrome, Mesangiocapillary glomerulonephritis

What do these columns mean?

Connections in cluster: How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners: How many of those links are statistically significant (FDR q < 0.05).
Curated genes: Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes): How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y): x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count: Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment: Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value: Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster): Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster): Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵	Source ⇵	Overlap genes ⇵	Fold enrichment ⇵	P-value ⇵	FDR q-value ⇵
Complement and coagulation cascades C3, CD46, CFB, CFH, CFHR1, CFHR3, CFHR5, CFI, PLG, THBD, CFHR4, CFHR2	KEGG	13 / 88	52.2×	5.71e-20	3.89e-17 ✓ sig.
Regulation of Complement cascade C3, CD46, CFB, CFH, CFHR1, CFHR3, CFHR5, CFI, CFHR4, CFHR2	Reactome	10 / 47	75.2×	3.70e-17	1.61e-14 ✓ sig.
Interleukin-10 signaling IL1A, IL1B, IL1RN, IL6, TNF	Reactome	5 / 47	37.6×	1.89e-7	1.14e-5 ✓ sig.
Malaria HBB, CD36, IL1B, IL6, TNF	KEGG	5 / 50	35.3×	2.59e-7	1.50e-5 ✓ sig.
Staphylococcus aureus infection C3, CFB, CFH, CFI, PLG, MBL2	KEGG	6 / 99	21.4×	3.00e-7	1.71e-5 ✓ sig.
Hematopoietic cell lineage CD36, EPO, IL1A, IL1B, IL6, TNF	KEGG	6 / 100	21.2×	3.19e-7	1.81e-5 ✓ sig.
AGE-RAGE signaling pathway in diabetic complications COL4A5, THBD, IL1A, IL1B, IL6, TNF	KEGG	6 / 101	21.0×	3.38e-7	1.90e-5 ✓ sig.
Pertussis C3, IL1A, IL1B, IL6, TNF	KEGG	5 / 78	22.6×	2.44e-6	1.06e-4 ✓ sig.
African trypanosomiasis HBB, IL1B, IL6, TNF	KEGG	4 / 37	38.2×	3.31e-6	1.37e-4 ✓ sig.
Graft-versus-host disease IL1A, IL1B, IL6, TNF	KEGG	4 / 45	31.4×	7.35e-6	2.66e-4 ✓ sig.
Interleukin-4 and Interleukin-13 signaling CD36, IL1A, IL1B, IL6, TNF	Reactome	5 / 108	16.4×	1.21e-5	4.00e-4 ✓ sig.
Legionellosis C3, IL1B, IL6, TNF	KEGG	4 / 56	25.2×	1.77e-5	5.50e-4 ✓ sig.
Inflammatory bowel disease IL1A, IL1B, IL6, TNF	KEGG	4 / 66	21.4×	3.41e-5	9.44e-4 ✓ sig.
Purinergic signaling in leishmaniasis infection C3, IL1A, IL1B	Reactome	3 / 24	44.2×	4.03e-5	1.09e-3 ✓ sig.
Fluid shear stress and atherosclerosis THBD, IL1A, IL1B, NQO1, TNF	KEGG	5 / 141	12.5×	4.39e-5	1.17e-3 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵	GO ID ⇵	Overlap genes ⇵	Fold enrichment ⇵	P-value ⇵	FDR q-value ⇵
complement activation C3, CFB, CFH, CFHR1, CFHR3, CFHR5, CFI, CFHR4, CFHR2, MBL2	GO:0006956	10 / 35	157×	1.64e-20	2.80e-17 ✓ sig.
complement activation, alternative pathway C3, CFB, CFH, CFHR5	GO:0006957	4 / 16	137×	1.64e-8	2.59e-6 ✓ sig.
vascular endothelial growth factor production IL1B, IL6, TNF	GO:0010573	3 / 6	275×	1.10e-7	1.32e-5 ✓ sig.
positive regulation of vascular endothelial growth factor production C3, IL1A, IL1B, IL6	GO:0010575	4 / 32	68.7×	3.17e-7	3.22e-5 ✓ sig.
acute-phase response EPO, IL1RN, IL6, MBL2	GO:0006953	4 / 37	59.4×	5.78e-7	5.33e-5 ✓ sig.
complement activation, classical pathway C3, CD46, CFI, MBL2	GO:0006958	4 / 37	59.4×	5.78e-7	5.33e-5 ✓ sig.
cytolysis by host of symbiont cells CFHR1, CFHR5, CFHR2	GO:0051838	3 / 11	150×	8.99e-7	7.66e-5 ✓ sig.
positive regulation of nitric oxide biosynthetic process HBB, CD36, IL1B, TNF	GO:0045429	4 / 42	52.3×	9.73e-7	8.17e-5 ✓ sig.
cellular response to lipopolysaccharide ADAMTS13, CD36, IL1A, IL1B, IL6, TNF	GO:0071222	6 / 187	17.6×	9.87e-7	8.26e-5 ✓ sig.
positive regulation of interleukin-6 production CD36, IL1A, IL1B, IL6, TNF	GO:0032755	5 / 103	26.7×	1.13e-6	9.25e-5 ✓ sig.
activation of membrane attack complex C3, CFB, MBL2	GO:0001905	3 / 13	127×	1.55e-6	1.20e-4 ✓ sig.
positive regulation of neuroinflammatory response IL1B, IL6, TNF	GO:0150078	3 / 16	103×	3.03e-6	2.05e-4 ✓ sig.
positive regulation of blood microparticle formation CD36, TNF	GO:2000334	2 / 2	550×	3.21e-6	2.15e-4 ✓ sig.
defense response to Gram-positive bacterium CD36, IL1B, IL6, MBL2, TNF	GO:0050830	5 / 135	20.4×	4.30e-6	2.71e-4 ✓ sig.
positive regulation of macrophage derived foam cell differentiation CD36, IL1B, TNF	GO:0010744	3 / 21	78.5×	7.16e-6	4.08e-4 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵	Disease B ⇵	Similarity score ⇵	Shared genes ⇵	P-value ⇵	FDR q-value ⇵
Hemolytic uremic syndrome	Mesangiocapillary glomerulonephritis	0.235	8	1.77e-22	3.78e-21 ✓ sig.
C3 glomerulonephritis	Mesangiocapillary glomerulonephritis	0.545	6	4.24e-20	8.15e-19 ✓ sig.
C3 glomerulonephritis	Hemolytic uremic syndrome	0.200	7	8.39e-19	1.50e-17 ✓ sig.
atypical hemolytic-uremic syndrome with B factor anomaly	C3 glomerulonephritis	0.111	1	5.20e-4	1.06e-3 ✓ sig.
atypical hemolytic-uremic syndrome with B factor anomaly	Mesangiocapillary glomerulonephritis	0.111	1	5.20e-4	1.06e-3 ✓ sig.
Hemolytic uremic syndrome	hemolytic uremic syndrome, atypical, 8, with rhizomelic short stature	0.029	1	2.14e-3	3.04e-3 ✓ sig.

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