Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 194

8 diseases · 16 shared-gene connections
8 Diseases
34 Unique genes
0.203 Avg. similarity score
Anterior compartment syndrome Most-connected disease (5 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Anterior compartment syndrome 5 5 1
Heme oxygenase deficiency 5 5 1
Pancreatic diseases 5 5 6
heme oxygenase 1 deficiency 5 5 1
Hemolysis 4 4 6
Intracranial vasospasm 3 3 7
Vascular system injury 3 3 10
Diabetic cardiomyopathy 2 2 14

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
HMOX1 7 / 8 Anterior compartment syndrome, heme oxygenase 1 deficiency, Heme oxygenase deficiency, Hemolysis and 3 more
SPP1 3 / 8 Diabetic cardiomyopathy, Pancreatic diseases, Vascular system injury
AGTR2 2 / 8 Diabetic cardiomyopathy, Vascular system injury
ATP7A 2 / 8 Hemolysis, Vascular system injury
LEPR 2 / 8 Diabetic cardiomyopathy, Pancreatic diseases
TNF 2 / 8 Diabetic cardiomyopathy, Vascular system injury
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Diabetic cardiomyopathy
AGT, ATP2A2, INS, RYR2, SLC25A4, G6PD, AGER, ACE
 KEGG 8 / 205 13.8× 7.80e-8 5.25e-6 ✓ sig.
Hypertrophic cardiomyopathy
AGT, ATP2A2, IGF1, RYR2, TNF, ACE
 KEGG 6 / 99 21.4× 3.00e-7 1.71e-5 ✓ sig.
Renin-angiotensin system
AGT, AGTR2, KLK1, ACE
 KEGG 4 / 23 61.4× 4.56e-7 2.47e-5 ✓ sig.
Hormone signaling
AGT, AGTR2, IGF1, INS, LEPR, SLC40A1, POMC
 KEGG 7 / 219 11.3× 2.16e-6 9.37e-5 ✓ sig.
Scavenging of heme from plasma
APOA1, HP, ALB
 Reactome 3 / 13 81.5× 5.82e-6 2.15e-4 ✓ sig.
Dilated cardiomyopathy
AGT, ATP2A2, IGF1, RYR2, TNF
 KEGG 5 / 105 16.8× 1.06e-5 3.51e-4 ✓ sig.
Peptide ligand-binding receptors
AGT, AGTR2, POMC, BDKRB1, BDKRB2
 Reactome 5 / 106 16.7× 1.11e-5 3.65e-4 ✓ sig.
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
APOA1, IGF1, KLK1, SPP1, ALB
 Reactome 5 / 125 14.1× 2.46e-5 7.08e-4 ✓ sig.
G alpha (i) signalling events
AGT, AGTR2, POMC, BDKRB1, BDKRB2, S1PR1
 Reactome 6 / 249 8.5× 6.18e-5 1.52e-3 ✓ sig.
Neuroactive ligand-receptor interaction
AGT, AGTR2, LEPR, POMC, BDKRB1, BDKRB2, S1PR1
 KEGG 7 / 370 6.7× 6.52e-5 1.58e-3 ✓ sig.
Calcium signaling pathway
ATP2A2, RYR2, SLC25A4, BDKRB1, BDKRB2, RYR1
 KEGG 6 / 254 8.3× 6.90e-5 1.65e-3 ✓ sig.
Advanced glycosylation endproduct receptor signaling
AGER, S100B
 Reactome 2 / 8 88.3× 2.16e-4 4.14e-3 ✓ sig.
Interleukin-4 and Interleukin-13 signaling
HMOX1, TNF, POMC, S1PR1
 Reactome 4 / 108 13.1× 2.33e-4 4.41e-3 ✓ sig.
Pathways of neurodegeneration - multiple diseases
ATP2A2, RYR2, SLC25A4, TNF, SOD1, AGER, RYR1
 KEGG 7 / 480 5.2× 3.28e-4 5.75e-3 ✓ sig.
HDL remodeling
APOA1, ALB
 Reactome 2 / 10 70.6× 3.45e-4 5.98e-3 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
vasodilation
AGTR2, INS, TNF, ACE, BDKRB2, S100A1
 GO:0042311 6 / 50 66.0× 3.42e-10 8.58e-8 ✓ sig.
blood vessel remodeling
AGT, AGTR2, IGF1, ATP7A, ACE
 GO:0001974 5 / 42 65.4× 1.19e-8 1.99e-6 ✓ sig.
positive regulation of cytokine production
AGT, INS, TNF, SOD1, AGER
 GO:0001819 5 / 81 33.9× 3.40e-7 3.38e-5 ✓ sig.
regulation of blood pressure
AGT, AGTR2, SOD1, POMC, ACE
 GO:0008217 5 / 83 33.1× 3.85e-7 3.75e-5 ✓ sig.
nitric oxide-cGMP-mediated signaling
AGT, AGTR2, INS
 GO:0038060 3 / 10 165× 6.55e-7 5.87e-5 ✓ sig.
positive regulation of smooth muscle cell proliferation
HMOX1, IGF1, TNF, S1PR1
 GO:0048661 4 / 52 42.3× 2.32e-6 1.62e-4 ✓ sig.
cellular response to amyloid-beta
APOA1, IGF1, TNF, AGER
 GO:1904646 4 / 53 41.5× 2.51e-6 1.73e-4 ✓ sig.
angiotensin-activated signaling pathway
AGT, AGTR2, ACE
 GO:0038166 3 / 16 103× 3.03e-6 2.01e-4 ✓ sig.
regulation of renal output by angiotensin
AGT, ACE
 GO:0002019 2 / 2 550× 3.21e-6 2.11e-4 ✓ sig.
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
AGT, AGTR2
 GO:0007199 2 / 2 550× 3.21e-6 2.11e-4 ✓ sig.
regulation of vasoconstriction
AGT, ACE, BDKRB2
 GO:0019229 3 / 23 71.7× 9.51e-6 5.02e-4 ✓ sig.
response to hypoxia
RYR2, TNF, AGER, PLAT, RYR1
 GO:0001666 5 / 176 15.6× 1.56e-5 7.42e-4 ✓ sig.
inflammatory response
AGTR2, TNF, HP, AGER, BDKRB1, BDKRB2, NFE2L2
 GO:0006954 7 / 467 8.2× 1.74e-5 8.05e-4 ✓ sig.
negative regulation of neurotrophin TRK receptor signaling pathway
AGT, AGTR2
 GO:0051387 2 / 4 275× 1.92e-5 8.71e-4 ✓ sig.
response to macrophage colony-stimulating factor
SPP1, TNF
 GO:0036005 2 / 4 275× 1.92e-5 8.71e-4 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Diabetic cardiomyopathy Vascular system injury 0.136 3 7.15e-8 5.45e-7 ✓ sig.
Pancreatic diseases Vascular system injury 0.133 2 5.69e-6 3.09e-5 ✓ sig.
Hemolysis Vascular system injury 0.133 2 5.69e-6 3.09e-5 ✓ sig.
Diabetic cardiomyopathy Pancreatic diseases 0.105 2 1.15e-5 5.97e-5 ✓ sig.
Anterior compartment syndrome Heme oxygenase deficiency 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Anterior compartment syndrome heme oxygenase 1 deficiency 0.500 1 6.49e-5 2.34e-4 ✓ sig.
heme oxygenase 1 deficiency Heme oxygenase deficiency 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Anterior compartment syndrome Hemolysis 0.143 1 3.90e-4 8.52e-4 ✓ sig.
Anterior compartment syndrome Pancreatic diseases 0.143 1 3.90e-4 8.52e-4 ✓ sig.
heme oxygenase 1 deficiency Hemolysis 0.143 1 3.90e-4 8.52e-4 ✓ sig.
heme oxygenase 1 deficiency Pancreatic diseases 0.143 1 3.90e-4 8.52e-4 ✓ sig.
Heme oxygenase deficiency Hemolysis 0.143 1 3.90e-4 8.52e-4 ✓ sig.
Heme oxygenase deficiency Pancreatic diseases 0.143 1 3.90e-4 8.52e-4 ✓ sig.
Anterior compartment syndrome Intracranial vasospasm 0.125 1 4.55e-4 9.55e-4 ✓ sig.
heme oxygenase 1 deficiency Intracranial vasospasm 0.125 1 4.55e-4 9.55e-4 ✓ sig.
Heme oxygenase deficiency Intracranial vasospasm 0.125 1 4.55e-4 9.55e-4 ✓ sig.