UBE2D3 (ubiquitin conjugating enzyme E2 D3)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 7323 |
| Gene name | Ubiquitin conjugating enzyme E2 D3 |
| Gene symbol | UBE2D3 |
| Synonyms (NCBI Gene) |
E2(17)KB3UBC4/5UBCH5C
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| Chromosome | 4 |
| Chromosome location | 4q24 |
| Summary | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conju |
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miRNA
miRNA information provided by mirtarbase database.
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Transcription factors
Transcription factors information provided by TRRUST V2 database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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P61077 | ||||||||||
| Protein name | Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzym | ||||||||||
| Protein function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:15247280, PubMed:15496420, PubMed:18284575, PubMed:20061386, PubMed:21532592, PubMed:28322253). In vitro catalyzes 'Lys-11'-, as well as 'Lys-4 | ||||||||||
| PDB | 1X23 , 2FUH , 3L1Z , 3RPG , 3UGB , 4BVU , 4R8P , 4S3O , 5EGG , 5IFR , 6CP0 , 6T7F , 7JZV , 7LYB , 8AMS , 8GRQ , 8SMW , 8SMX , 8SMY , 8SMZ , 8SN0 , 8SN1 , 8SN2 , 8SN3 , 8SN4 , 8SN5 , 8SN6 , 8SN7 , 8SN8 , 8SN9 , 8SNA , 8U14 , 8UPF , 8UQ8 , 8UQ9 , 8UQA , 8UQB , 8UQC , 8UQD , 8UQE , 8X7I , 8X7J , 8X7K , 9IPU | ||||||||||
| Family and domains |
Pfam
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| Sequence | |||||||||||
| Sequence length | 147 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with UBE2D3 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to UBE2D3 (see Related Genes above), that are NOT already directly curated for UBE2D3 itself -- a lead worth checking, not a confirmed association.
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