PLA2G2E (phospholipase A2 group IIE)

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Gene Gene information from NCBI Gene database.
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Entrez ID 30814
Gene name Phospholipase A2 group IIE
Gene symbol PLA2G2E
Synonyms (NCBI Gene)
GIIE sPLA2sPLA2-IIE
Chromosome 1
Chromosome location 1p36.13
miRNA miRNA information provided by mirtarbase database.
1
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miRTarBase ID miRNA Experiments Reference
MIRT017753 hsa-miR-335-5p Microarray 18185580
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0004623 Function Phospholipase A2 activity IEA
GO:0004623 Function Phospholipase A2 activity TAS 10681567
GO:0005509 Function Calcium ion binding IBA
GO:0005509 Function Calcium ion binding IDA 28883454
GO:0005509 Function Calcium ion binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
618320 13414 ENSG00000188784
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NZK7
Protein name Group IIE secretory phospholipase A2 (GIIE sPLA2) (sPLA2-IIE) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 2E)
Protein function Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:10681567, PubMed:11922621, PubMed:28883454). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (ph
PDB 5WZM , 5WZO , 5WZS , 5WZT , 5WZU , 5WZV , 5WZW , 5Y5E , 6KQU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00068 Phospholip_A2_1 21 → 128 Phospholipase A2 Domain
Tissue specificity TISSUE SPECIFICITY: Restricted to the brain, heart, lung, and placenta. {ECO:0000269|PubMed:10681567}.
Sequence
Sequence length 142
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway Reactome Pathway
Glycerophospholipid metabolism Acyl chain remodelling of PC
Ether lipid metabolism Acyl chain remodelling of PS
Arachidonic acid metabolism Acyl chain remodelling of PE
Linoleic acid metabolism Acyl chain remodelling of PI
alpha-Linolenic acid metabolism Acyl chain remodelling of PG
Metabolic pathways Synthesis of PA
Ras signaling pathway  
Vascular smooth muscle contraction  
Pancreatic secretion  
Fat digestion and absorption  
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PLA2G2D 15 shared pathwaysGlycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, Linoleic acid metabolism, alpha-Linolenic acid metabolism, Ras signaling pathway, Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Acyl chain remodelling of PC, Acyl chain remodelling of PS, Acyl chain remodelling of PE +3 more Related via 15 shared pathways including Glycerophospholipid metabolism, Ether lipid metabolism. PLA2G1B 15 shared pathwaysGlycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, Linoleic acid metabolism, alpha-Linolenic acid metabolism, Ras signaling pathway, Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Acyl chain remodelling of PC, Acyl chain remodelling of PS, Acyl chain remodelling of PE +3 more Related via 15 shared pathways including Glycerophospholipid metabolism, Ether lipid metabolism. PLA2G5 15 shared pathwaysGlycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, Linoleic acid metabolism, alpha-Linolenic acid metabolism, Ras signaling pathway, Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Acyl chain remodelling of PC, Acyl chain remodelling of PS, Acyl chain remodelling of PE +3 more Related via 15 shared pathways including Glycerophospholipid metabolism, Ether lipid metabolism. PLA2G2F 15 shared pathwaysGlycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, Linoleic acid metabolism, alpha-Linolenic acid metabolism, Ras signaling pathway, Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Acyl chain remodelling of PC, Acyl chain remodelling of PS, Acyl chain remodelling of PE +3 more Related via 15 shared pathways including Glycerophospholipid metabolism, Ether lipid metabolism. PLA2G12A 15 shared pathwaysGlycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, Linoleic acid metabolism, alpha-Linolenic acid metabolism, Ras signaling pathway, Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Acyl chain remodelling of PC, Acyl chain remodelling of PS, Acyl chain remodelling of PE +3 more Related via 15 shared pathways including Glycerophospholipid metabolism, Ether lipid metabolism.
Crohn disease Linked via 2 of 5 related genesPLA2G2D, PLA2G5 Inflammatory bowel disease Linked via 2 of 5 related genesPLA2G2D, PLA2G5 Obesity Linked via 2 of 5 related genesPLA2G2D, PLA2G2F Attention deficit hyperactivity disorder Linked via 1 of 5 related genesPLA2G1B Bipolar disorder Linked via 1 of 5 related genesPLA2G1B