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Gene Gene information from NCBI Gene database.
Entrez ID 1783
Gene name Dynein cytoplasmic 1 light intermediate chain 2
Gene symbol DYNC1LI2
Synonyms (NCBI Gene)
DNCLI2LIC2
Chromosome 16
Chromosome location 16q22.1
Summary Cytoplasmic dynein is a microtubule-associated motor protein (Hughes et al., 1995 [PubMed 7738094]). See DYNC1H1 (MIM 600112) for general information about dyneins.[supplied by OMIM, Mar 2008]
miRNA miRNA information provided by mirtarbase database.
1273 Show/Hide all (1273)
miRTarBase ID miRNA Experiments Reference
MIRT030895 hsa-miR-21-5p Microarray 18591254
MIRT051385 hsa-let-7f-5p CLASH 23622248
MIRT558281 hsa-miR-130b-3p PAR-CLIP 21572407
MIRT558280 hsa-miR-454-3p PAR-CLIP 21572407
MIRT558278 hsa-miR-4295 PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25 Show/Hide all (25)
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000226 Process Microtubule cytoskeleton organization IBA
GO:0000226 Process Microtubule cytoskeleton organization IEA
GO:0000776 Component Kinetochore IEA
GO:0005524 Function ATP binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611406 2966 ENSG00000135720
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O43237
Protein name Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55)
Protein function Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor
PDB 6F1T , 6F1Y , 6F38 , 6F3A , 7Z8F , 7Z8I , 7Z8J , 7Z8K , 7Z8L , 8PR0 , 8PR1 , 8PR2 , 8PR3 , 8PTK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05783 DLIC 30 → 491 Dynein light intermediate chain (DLIC) Family
Sequence
Sequence length 492
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Phagosome Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Motor proteins MHC class II antigen presentation
Vasopressin-regulated water reabsorption Separation of Sister Chromatids
Salmonella infection Resolution of Sister Chromatid Cohesion
  HSP90 chaperone cycle for steroid hormone receptors (SHR)
  RHO GTPases Activate Formins
  COPI-mediated anterograde transport
  COPI-independent Golgi-to-ER retrograde traffic
  Mitotic Prometaphase
  HCMV Early Events
  Aggrephagy
  EML4 and NUDC in mitotic spindle formation