Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	766
Gene name	Carbonic anhydrase 7
Gene symbol	CA7
Synonyms (NCBI Gene)	CA-VIICAVII
Chromosome	16
Chromosome location	16q22.1
Summary	Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and th

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miRTarBase ID	miRNA	Experiments
MIRT856748	hsa-miR-1224-3p	CLIP-seq
MIRT856749	hsa-miR-1913	CLIP-seq
MIRT856750	hsa-miR-298	CLIP-seq
MIRT856751	hsa-miR-3151	CLIP-seq
MIRT856752	hsa-miR-3158-5p	CLIP-seq
MIRT856753	hsa-miR-3194-3p	CLIP-seq
MIRT856754	hsa-miR-324-3p	CLIP-seq
MIRT856755	hsa-miR-365	CLIP-seq
MIRT856756	hsa-miR-4283	CLIP-seq
MIRT856757	hsa-miR-4489	CLIP-seq
MIRT856758	hsa-miR-4651	CLIP-seq
MIRT856759	hsa-miR-4660	CLIP-seq
MIRT856760	hsa-miR-4735-5p	CLIP-seq
MIRT856761	hsa-miR-596	CLIP-seq
MIRT856762	hsa-miR-608	CLIP-seq
MIRT856763	hsa-miR-648	CLIP-seq
MIRT856764	hsa-miR-933	CLIP-seq
MIRT856765	hsa-miR-944	CLIP-seq
MIRT2495491	hsa-miR-1270	CLIP-seq
MIRT2495492	hsa-miR-185	CLIP-seq
MIRT2495493	hsa-miR-193a-5p	CLIP-seq
MIRT2495494	hsa-miR-2278	CLIP-seq
MIRT2495495	hsa-miR-2467-3p	CLIP-seq
MIRT2495496	hsa-miR-4306	CLIP-seq
MIRT2495497	hsa-miR-432	CLIP-seq
MIRT2495498	hsa-miR-4468	CLIP-seq
MIRT2495499	hsa-miR-4531	CLIP-seq
MIRT2495500	hsa-miR-4644	CLIP-seq
MIRT2495501	hsa-miR-620	CLIP-seq
MIRT2495502	hsa-miR-9	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004089	Function	Carbonate dehydratase activity	IBA
GO:0004089	Function	Carbonate dehydratase activity	IEA
GO:0004089	Function	Carbonate dehydratase activity	TAS	1783392
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0008270	Function	Zinc ion binding	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0032230	Process	Positive regulation of synaptic transmission, GABAergic	IEA
GO:0032849	Process	Positive regulation of cellular pH reduction	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051453	Process	Regulation of intracellular pH	IBA
GO:0070050	Process	Neuron cellular homeostasis	IEA
GO:2001225	Process	Regulation of chloride transport	IEA

MIM	HGNC	e!Ensembl
114770	1381	ENSG00000168748

P43166

Protein name

Carbonic anhydrase 7 (EC 4.2.1.1) (Carbonate dehydratase VII) (Carbonic anhydrase VII) (CA-VII)

Protein function

Reversible hydration of carbon dioxide.

PDB

3MDZ , 3ML5 , 6G4T , 6H36 , 6H37 , 6H38 , 6SDT , 6ZR9 , 7NC4 , 7P1A , 8Q3U

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00194	Carb_anhydrase	6 → 261	Eukaryotic-type carbonic anhydrase	Domain

Sequence

MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLS
ITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSEL
HLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSC
FNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDER
IHMVNNFRPPQPLKGRVVKASFRA

Sequence length

264

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Nitrogen metabolism	Reversible hydration of carbon dioxide
Metabolic pathways

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Clear cell carcinoma of kidney	Likely benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Likely benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Likely benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (7)
Colorectal Carcinoma	Colorectal Cancer	BEFREE	25885898		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	25885898	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	26208990, 35114976, 37895185	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Febrile Convulsions	Febrile seizures	BEFREE	23881097		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin disease	Pubtator	6370286	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	25885898	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	25885898		★★★★★ ★☆☆☆☆ Found in Text Mining only

CA7 (carbonic anhydrase 7)

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