Multiple sclerosis

Ras signaling pathway Phospholipase D signaling pathway Efferocytosis Axon guidance C-type lectin receptor signaling pathway JAK-STAT signaling pathway Natural killer cell mediated cytotoxicity T cell receptor signaling pathway Leukocyte transendothelial migration Neurotrophin signaling pathway Adipocytokine signaling pathway Insulin resistance Epithelial cell signaling in Helicobacter pylori infection Pathogenic Escherichia coli infection Herpes simplex virus 1 infection Proteoglycans in cancer Chemical carcinogenesis - reactive oxygen species Renal cell carcinoma Chronic myeloid leukemia PD-L1 expression and PD-1 checkpoint pathway in cancer Interleukin-6 signaling PI3K Cascade MAPK3 (ERK1) activation MAPK1 (ERK2) activation GPVI-mediated activation cascade PIP3 activates AKT signaling Spry regulation of FGF signaling Signaling by SCF-KIT GAB1 signalosome Downstream signal transduction PECAM1 interactions Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer Costimulation by the CD28 family CTLA4 inhibitory signaling PD-1 signaling Platelet sensitization by LDL Interleukin-3, Interleukin-5 and GM-CSF signaling PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Interleukin-20 family signaling MET activates PTPN11 Regulation of RUNX1 Expression and Activity Interleukin-37 signaling Interferon alpha/beta signaling Regulation of IFNA signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon +56 more

Cell adhesion molecules T cell receptor signaling pathway Fc gamma R-mediated phagocytosis Salmonella infection Primary immunodeficiency Phosphorylation of CD3 and TCR zeta chains Other semaphorin interactions Neutrophil degranulation +5 more

EGFR downregulation

Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint +3 more

RAF/MAP kinase cascade

MAPK signaling pathway Ras signaling pathway Focal adhesion RAF/MAP kinase cascade +1 more

MAPK signaling pathway Ras signaling pathway Platelet activation T cell receptor signaling pathway Pathways in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Activation of RAS in B cells Integrin signaling Rap1 signalling RAF/MAP kinase cascade +7 more

Spliceosome mRNA Splicing - Major Pathway

Notch signaling pathway Th1 and Th2 cell differentiation Spinocerebellar ataxia Human papillomavirus infection Epstein-Barr virus infection Viral carcinogenesis Pre-NOTCH Transcription and Translation NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription +12 more

Huntington disease HDACs deacetylate histones Factors involved in megakaryocyte development and platelet production

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Spinocerebellar ataxia Human papillomavirus infection Reelin signalling pathway +3 more

Defective RFT1 causes RFT1-CDG (CDG-1n)

Regulation of actin cytoskeleton TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

TGF-beta signaling pathway Axon guidance

G alpha (q) signalling events G alpha (i) signalling events

Rap1 signaling pathway G alpha (i) signalling events

Leukocyte transendothelial migration Salmonella infection Rho GTPase cycle

Fanconi anemia pathway HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint +7 more

NOD-like receptor signaling pathway Hepatitis C Influenza A Herpes simplex virus 1 infection OAS antiviral response Interferon alpha/beta signaling +3 more

Antigen processing: Ubiquitination & Proteasome degradation

Nicotinamide salvaging

Th17 cell differentiation Circadian rhythm Spinocerebellar ataxia Inflammatory bowel disease RORA activates gene expression PPARA activates gene expression Nuclear Receptor transcription pathway Circadian Clock SUMOylation of intracellular receptors Interleukin-4 and Interleukin-13 signaling +7 more

RNA polymerase II transcribes snRNA genes

Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +7 more

Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +10 more

MAPK signaling pathway Adrenergic signaling in cardiomyocytes TNF signaling pathway Circadian entrainment Neurotrophin signaling pathway Shigellosis Pathways in cancer MicroRNAs in cancer Bladder cancer ERK/MAPK targets CREB phosphorylation NCAM signaling for neurite out-growth CD209 (DC-SIGN) signaling +10 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway HIF-1 signaling pathway Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species TGF-beta signaling pathway Apelin signaling pathway Fc gamma R-mediated phagocytosis Thermogenesis Insulin signaling pathway Insulin resistance Shigellosis Human cytomegalovirus infection Human papillomavirus infection Human immunodeficiency virus 1 infection Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - receptor activation Colorectal cancer Pancreatic cancer Acute myeloid leukemia Breast cancer Hepatocellular carcinoma Gastric cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer mTORC1-mediated signalling +29 more

MAPK signaling pathway Ras signaling pathway cAMP signaling pathway Phospholipase D signaling pathway Mitophagy - animal Autophagy - animal Cellular senescence Apelin signaling pathway C-type lectin receptor signaling pathway Regulation of actin cytoskeleton Proteoglycans in cancer +8 more

Th1 and Th2 cell differentiation Epstein-Barr virus infection Binding of TCF/LEF:CTNNB1 to target gene promoters RUNX3 regulates CDKN1A transcription RUNX3 regulates NOTCH signaling Regulation of RUNX3 expression and activity RUNX3 Regulates Immune Response and Cell Migration RUNX3 regulates WNT signaling RUNX3 regulates YAP1-mediated transcription RUNX3 regulates RUNX1-mediated transcription RUNX3 regulates p14-ARF RUNX3 regulates BCL2L11 (BIM) transcription +9 more

Ubiquitin mediated proteolysis SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9)

Cell adhesion molecules TNF signaling pathway AGE-RAGE signaling pathway in diabetic complications African trypanosomiasis Malaria Lipid and atherosclerosis Fluid shear stress and atherosclerosis Cell surface interactions at the vascular wall +5 more

Lysine degradation Metabolic pathways PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function +1 more

Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Viral myocarditis +2 more

Glycerophospholipid metabolism Sphingolipid metabolism Metabolic pathways Sphingolipid signaling pathway Sphingolipid de novo biosynthesis +2 more

Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production

VEGF signaling pathway VEGFA-VEGFR2 Pathway

Natural killer cell mediated cytotoxicity

Yersinia infection Signal regulatory protein family interactions