Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TM9SF2	Unknown	24076602	GWAS catalog	—
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TMEM114	Unknown	36448302	GWAS catalog	—
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TMEM244	Unknown	31604244	GWAS catalog	—
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TMEM47	Unknown	23412934	GWAS catalog	—
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TMEM8B	Unknown	31604244	GWAS catalog	—
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TNF	Unknown	—	Disgenet	Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +72 more
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TNFAIP3	Unknown	24076602	CTD, Disgenet	NF-kappa B signaling pathway Necroptosis NOD-like receptor signaling pathway +10 more
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TNFAIP8	Unknown	31604244	GWAS catalog	PI Metabolism
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TNFRSF14	Unknown	27386562 28445677	GWAS catalog	Virion - Herpesvirus Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor +3 more
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TNFSF14	Unknown	21833088 24076602 31604244 40262193	CTD, Disgenet, GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor NF-kappa B signaling pathway +4 more
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TNFSF4	Unknown	23412934	GWAS catalog	Cytokine-cytokine receptor interaction TNFs bind their physiological receptors
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TNIP2	Unknown	31604244	GWAS catalog	MAP3K8 (TPL2)-dependent MAPK1/3 activation Ovarian tumor domain proteases
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TNIP3	Unknown	31604244	GWAS catalog	Ovarian tumor domain proteases
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TNPO2	Unknown	31407831	GWAS catalog	Nucleocytoplasmic transport
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TOP3A	Unknown	27386562	GWAS catalog	Homologous recombination Fanconi anemia pathway HDR through Single Strand Annealing (SSA) +8 more
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TOX2	Unknown	31604244	GWAS catalog	—
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TRAF1	Unknown	31068361	CTD, Disgenet	NF-kappa B signaling pathway Apoptosis TNF signaling pathway +6 more
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TRAF3	Unknown	24076602 31604244 40262193	GWAS catalog	NF-kappa B signaling pathway Toll-like receptor signaling pathway NOD-like receptor signaling pathway +25 more
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TRAM1	Unknown	31604244	GWAS catalog	Protein processing in endoplasmic reticulum
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TRIM14	Unknown	31604244	GWAS catalog	Interferon gamma signaling
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TRIM2	Unknown	21654844	GWAS catalog	Interferon gamma signaling
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TRIM42	Unknown	19010793	GWAS catalog	—
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TRIM71	Unknown	31604244	GWAS catalog	MicroRNAs in cancer Antigen processing: Ubiquitination & Proteasome degradation
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TSBP1	Unknown	18941528 22457343	GWAS catalog	—
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TSFM	Unknown	24076602	GWAS catalog	—
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TSGA10IP	Unknown	31604244	GWAS catalog	—
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TSPAN31	Unknown	21833088	GWAS catalog	—
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TSPOAP1	Unknown	31604244	GWAS catalog	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Pregnenolone biosynthesis +3 more
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TTC28	Unknown	31604244	GWAS catalog	—
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TTC33	Unknown	19525953 21833088 22570697 24076602 28445677 31604244 40262193	GWAS catalog	—
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TTC34	Unknown	21833088	GWAS catalog	—
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TXK	Unknown	31604244	GWAS catalog	Leukocyte transendothelial migration FCERI mediated Ca+2 mobilization
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	TYK2	Unknown	19525955 24076602 31604244	CTD, Disgenet, GWAS catalog	Necroptosis Osteoclast differentiation Toll-like receptor signaling pathway +28 more
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	UBASH3B	Unknown	26920376 31604244	GWAS catalog	—
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	UBXN6	Unknown	31604244	GWAS catalog	Protein processing in endoplasmic reticulum
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	UCK2	Unknown	31604244	GWAS catalog	Pyrimidine metabolism Drug metabolism - other enzymes Metabolic pathways +2 more
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	UNK	Unknown	31604244	GWAS catalog	—
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	USP31	Unknown	19525955	GWAS catalog	—
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	VANGL2	Unknown	24076602 31604244	GWAS catalog	Wnt signaling pathway
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	VAV2	Unknown	20598377	GWAS catalog	Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway +24 more
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	VCAM1	Unknown	20175758 21833088 24076602 40262193	CTD, Disgenet, GWAS catalog	NF-kappa B signaling pathway Cell adhesion molecules TNF signaling pathway +10 more
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	VDAC1	Unknown	21833088 24076602 31604244	GWAS catalog	Calcium signaling pathway cGMP-PKG signaling pathway Necroptosis +19 more
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	VDR	Unknown	25853421	CTD, Disgenet	Parathyroid hormone synthesis, secretion and action Endocrine and other factor-regulated calcium reabsorption Mineral absorption +5 more
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	VHL	Unknown	31068361	CTD, Disgenet	HIF-1 signaling pathway Ubiquitin mediated proteolysis Pathways in cancer +5 more
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	VMP1	Unknown	24076602 31407831 31604244 40262193	GWAS catalog	Autophagy - animal
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	VTI1A	Unknown	23412934	GWAS catalog	SNARE interactions in vesicular transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	VWA8	Unknown	21833088	GWAS catalog	—
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	WDR46	Unknown	37377963	GWAS catalog	Major pathway of rRNA processing in the nucleolus and cytosol
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	WNT9B	Unknown	33704824	GWAS catalog	mTOR signaling pathway Wnt signaling pathway Hippo signaling pathway +13 more
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	WWOX	Unknown	24076602 31604244 40262193	GWAS catalog	Nuclear signaling by ERBB4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors

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Multiple sclerosis

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