Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	NFKB1	Unknown	24076602	GWAS catalog	Antifolate resistance MAPK signaling pathway Ras signaling pathway +96 more
		NFKBIL1	Unknown	37377963 39024449	GWAS catalog	—
		NLRC5	Unknown	31604244	GWAS catalog	DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling
		NLRP11	Unknown	19010793	GWAS catalog	—
		NLRP3	Unknown	25458313	CTD, Disgenet	Necroptosis NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway +12 more
		NOTCH4	Unknown	37377963	Disgenet, GWAS catalog	Endocrine resistance Notch signaling pathway Thyroid hormone signaling pathway +11 more
		NPEPPS	Unknown	24076602 24234648	GWAS catalog	Antigen processing: Ubiquitination & Proteasome degradation
		NR1D1	Unknown	31604244	GWAS catalog	Circadian rhythm PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis +2 more
		NR3C1	Unknown	31604244	GWAS catalog	Neuroactive ligand-receptor interaction HSP90 chaperone cycle for steroid hormone receptors (SHR) Nuclear Receptor transcription pathway +2 more
		NRROS	Unknown	31604244	GWAS catalog	TGF-beta signaling pathway
		NSL1	Unknown	31604244	GWAS catalog	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion +3 more
		NUBPL	Unknown	19010793	GWAS catalog	Complex I biogenesis
		OS9	Unknown	31604244 40262193	GWAS catalog	Protein processing in endoplasmic reticulum ABC-family proteins mediated transport Hedgehog ligand biogenesis +3 more
		P2RX7	Unknown	17728465	CTD, Disgenet	Calcium signaling pathway Neuroactive ligand-receptor interaction NOD-like receptor signaling pathway +4 more
		PADI1	Unknown	33296963	GWAS catalog	Chromatin modifying enzymes
		PCSK5	Unknown	19010793	GWAS catalog	NGF processing Assembly of active LPL and LIPC lipase complexes
		PDE4A	Unknown	31604244 40262193	GWAS catalog	Purine metabolism Metabolic pathways cAMP signaling pathway +4 more
		PDE4B	Unknown	31604244	GWAS catalog	Purine metabolism Metabolic pathways cAMP signaling pathway +3 more
		PDZRN4	Unknown	19010793	GWAS catalog	—
		PER2	Unknown	36448302	GWAS catalog	Circadian rhythm Circadian entrainment Transcriptional misregulation in cancer +1 more
		PFDN4	Unknown	21833088 24076602	GWAS catalog	—
		PHACTR2	Unknown	31604244	Disgenet, GWAS catalog	Platelet degranulation
		PHGDH	Unknown	24076602 31604244 40262193	GWAS catalog	Glycine, serine and threonine metabolism Cysteine and methionine metabolism Metabolic pathways +3 more
		PHKG1	Unknown	31604244	GWAS catalog	Calcium signaling pathway Insulin signaling pathway Glucagon signaling pathway +1 more
		PHLDB1	Unknown	31604244	GWAS catalog	—
		PHTF1	Unknown	37377963	GWAS catalog	—
		PITPNM2	Unknown	24076602 31604244 40262193	GWAS catalog	Synthesis of PI
		PKIA	Unknown	24076602 40262193	GWAS catalog	Alcoholism
		PLCL2	Unknown	21833088 26920376	GWAS catalog	—
		PLEC	Unknown	31604244	Disgenet, GWAS catalog	Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins +1 more
		PLEK	Unknown	21833088 22190364 24076602 31407831 31604244 40262193	GWAS catalog	Platelet degranulation
		PLEKHG5	Unknown	24076602	GWAS catalog	Pathways in cancer NRAGE signals death through JNK Rho GTPase cycle +1 more
		PLXNC1	Unknown	31604244	GWAS catalog	Axon guidance Other semaphorin interactions
		PNMT	Unknown	—	Disgenet	Tyrosine metabolism Metabolic pathways Catecholamine biosynthesis
		POLG	Unknown	—	Disgenet	Base excision repair
		POLR1H	Unknown	37377963	GWAS catalog	RNA polymerase
		POMC	Unknown	2843795 9664777	CTD, Disgenet	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +18 more
		POPDC3	Unknown	21654844	GWAS catalog	cAMP signaling pathway Adrenergic signaling in cardiomyocytes
		POU2AF1	Unknown	31604244	GWAS catalog	—
		PRDX5	Unknown	24076602 31604244	GWAS catalog	Peroxisome Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes
		PREX1	Unknown	40262193	GWAS catalog	Chemokine signaling pathway Kaposi sarcoma-associated herpesvirus infection NRAGE signals death through JNK +2 more
		PRF1	Unknown	—	Disgenet	Apoptosis Natural killer cell mediated cytotoxicity Type I diabetes mellitus +4 more
		PRICKLE1	Unknown	31604244	GWAS catalog	Wnt signaling pathway Asymmetric localization of PCP proteins
		PRNP	Unknown	31068361	CTD, Disgenet	Ferroptosis Prion disease Pathways of neurodegeneration - multiple diseases +1 more
		PRR16	Unknown	36448302	GWAS catalog	—
		PRR5L	Unknown	24076602 31604244	GWAS catalog	mTOR signaling pathway
		PRXL2B	Unknown	27386562 28445677 31604244 40262193	GWAS catalog	Arachidonic acid metabolism Metabolic pathways
		PSMB9	Unknown	—	Disgenet	Proteasome Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha +49 more
		PTGFR	Unknown	33296963	GWAS catalog	Calcium signaling pathway Phospholipase D signaling pathway Neuroactive ligand-receptor interaction +2 more
		PTGFRN	Unknown	31604244	GWAS catalog	—

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Multiple sclerosis

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