Multiple sclerosis

Endocrine resistance MAPK signaling pathway ErbB signaling pathway Ras signaling pathway cAMP signaling pathway FoxO signaling pathway Sphingolipid signaling pathway Mitophagy - animal Autophagy - animal Protein processing in endoplasmic reticulum Apoptosis Apoptosis - multiple species Necroptosis Wnt signaling pathway Osteoclast differentiation Focal adhesion Tight junction Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway C-type lectin receptor signaling pathway IL-17 signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway Fc epsilon RI signaling pathway TNF signaling pathway Neurotrophin signaling pathway Retrograde endocannabinoid signaling Dopaminergic synapse Inflammatory mediator regulation of TRP channels Insulin signaling pathway GnRH signaling pathway Progesterone-mediated oocyte maturation Prolactin signaling pathway Adipocytokine signaling pathway Relaxin signaling pathway Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Alcoholic liver disease Alzheimer disease Parkinson disease Huntington disease Spinocerebellar ataxia Prion disease Pathways of neurodegeneration - multiple diseases Epithelial cell signaling in Helicobacter pylori infection Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Yersinia infection Chagas disease Toxoplasmosis Tuberculosis Hepatitis B Measles Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Chemical carcinogenesis - reactive oxygen species Colorectal cancer Pancreatic cancer Choline metabolism in cancer Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors +74 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance MAPK signaling pathway ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway HIF-1 signaling pathway FoxO signaling pathway Sphingolipid signaling pathway Phospholipase D signaling pathway Oocyte meiosis Autophagy - animal Efferocytosis mTOR signaling pathway PI3K-Akt signaling pathway Apoptosis Cellular senescence Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction TGF-beta signaling pathway Axon guidance VEGF signaling pathway Apelin signaling pathway Osteoclast differentiation Focal adhesion Adherens junction Gap junction Signaling pathways regulating pluripotency of stem cells Platelet activation Neutrophil extracellular trap formation Toll-like receptor signaling pathway NOD-like receptor signaling pathway C-type lectin receptor signaling pathway Natural killer cell mediated cytotoxicity IL-17 signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway B cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis TNF signaling pathway Circadian entrainment Long-term potentiation Neurotrophin signaling pathway Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse Long-term depression Regulation of actin cytoskeleton Insulin signaling pathway GnRH signaling pathway Progesterone-mediated oocyte maturation Estrogen signaling pathway Melanogenesis Prolactin signaling pathway Thyroid hormone signaling pathway Oxytocin signaling pathway Relaxin signaling pathway Parathyroid hormone synthesis, secretion and action GnRH secretion Type II diabetes mellitus AGE-RAGE signaling pathway in diabetic complications Cushing syndrome Growth hormone synthesis, secretion and action Aldosterone-regulated sodium reabsorption Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Alcoholism Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Yersinia infection Leishmaniasis Chagas disease Toxoplasmosis Tuberculosis Hepatitis C Hepatitis B Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Glioma Prostate cancer Thyroid cancer Melanoma Bladder cancer Chronic myeloid leukemia Acute myeloid leukemia Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Lipid and atherosclerosis MAPK3 (ERK1) activation RAF-independent MAPK1/3 activation ISG15 antiviral mechanism Spry regulation of FGF signaling Golgi Cisternae Pericentriolar Stack Reorganization Frs2-mediated activation ERK/MAPK targets ERKs are inactivated Regulation of actin dynamics for phagocytic cup formation Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence FCERI mediated MAPK activation Regulation of HSF1-mediated heat shock response NCAM signaling for neurite out-growth Signal transduction by L1 Activation of the AP-1 family of transcription factors Thrombin signalling through proteinase activated receptors (PARs) Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate NADPH Oxidases RAF/MAP kinase cascade MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RNA Polymerase I Promoter Opening Signal attenuation Gastrin-CREB signalling pathway via PKC and MAPK ESR-mediated signaling Regulation of PTEN gene transcription Regulation of the apoptosome activity Suppression of apoptosis Signaling downstream of RAS mutants FCGR3A-mediated phagocytosis Growth hormone receptor signaling +158 more

Fc gamma R-mediated phagocytosis MicroRNAs in cancer Acetylcholine regulates insulin secretion

EGR2 and SOX10-mediated initiation of Schwann cell myelination

cGMP-PKG signaling pathway Apelin signaling pathway Myogenesis

MAPK signaling pathway cGMP-PKG signaling pathway Apelin signaling pathway Oxytocin signaling pathway Parathyroid hormone synthesis, secretion and action Transcriptional misregulation in cancer Fluid shear stress and atherosclerosis Transcriptional activation of mitochondrial biogenesis Circadian Clock Myogenesis +7 more

Efferocytosis Cell surface interactions at the vascular wall

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Axon guidance Focal adhesion Adherens junction Bacterial invasion of epithelial cells Epithelial cell signaling in Helicobacter pylori infection Malaria Pathways in cancer Transcriptional misregulation in cancer Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - reactive oxygen species Renal cell carcinoma Melanoma Non-small cell lung cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Sema4D mediated inhibition of cell attachment and migration RAF/MAP kinase cascade MET Receptor Activation Negative regulation of MET activity PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates RAS signaling MET activates PI3K/AKT signaling MET activates PTPN11 MET activates PTK2 signaling InlB-mediated entry of Listeria monocytogenes into host cell MET interacts with TNS proteins MET activates RAP1 and RAC1 MET receptor recycling MET activates STAT3 MECP2 regulates neuronal receptors and channels +37 more

N-Glycan biosynthesis Metabolic pathways N-Glycan antennae elongation

Natural killer cell mediated cytotoxicity Kaposi sarcoma-associated herpesvirus infection Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Oxidative Stress Induced Senescence

Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors G alpha (q) signalling events +1 more

Collagen degradation Degradation of the extracellular matrix

Endocrine resistance IL-17 signaling pathway TNF signaling pathway Leukocyte transendothelial migration Estrogen signaling pathway Relaxin signaling pathway Hepatitis B Pathways in cancer Transcriptional misregulation in cancer Proteoglycans in cancer MicroRNAs in cancer Prostate cancer Bladder cancer Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis Signaling by SCF-KIT Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Extra-nuclear estrogen signaling +22 more

ATP-dependent chromatin remodeling

Drug metabolism - other enzymes Phagosome Neutrophil extracellular trap formation Transcriptional misregulation in cancer Acute myeloid leukemia Neutrophil degranulation Events associated with phagocytolytic activity of PMN cells +4 more

Peroxisome

One carbon pool by folate Metabolic pathways Antifolate resistance Folate transport and metabolism Metabolism of folate and pterines +2 more

PI3K-Akt signaling pathway RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression

Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Dilated cardiomyopathy Striated Muscle Contraction +1 more

Motor proteins Pathogenic Escherichia coli infection Vasopressin regulates renal water homeostasis via Aquaporins

NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination

RNA polymerase II transcribes snRNA genes

COPI-dependent Golgi-to-ER retrograde traffic

Phagosome Osteoclast differentiation Neutrophil extracellular trap formation Leukocyte transendothelial migration Prion disease Leishmaniasis Diabetic cardiomyopathy Lipid and atherosclerosis ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases +10 more

Estrogen signaling pathway Thyroid hormone signaling pathway RORA activates gene expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) HATs acetylate histones Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Estrogen-dependent gene expression +14 more

Notch signaling pathway Epstein-Barr virus infection PPARA activates gene expression Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis +11 more

Oxidative phosphorylation Metabolic pathways Thermogenesis Retrograde endocannabinoid signaling Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy Respiratory electron transport Complex I biogenesis +11 more

Oxidative phosphorylation Metabolic pathways Thermogenesis Retrograde endocannabinoid signaling Non-alcoholic fatty liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy Respiratory electron transport Complex I biogenesis +12 more

Virion - Herpesvirus Cell adhesion molecules Adherens junction Herpes simplex virus 1 infection Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adherens junctions interactions Nectin/Necl trans heterodimerization +4 more