Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	HLA-DOA	Unknown	37377963	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +22 more
		HLA-DOB	Unknown	37377963	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +22 more
		HLA-DPA1	Unknown	37377963	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DPB1	Unknown	17956852	CTD, Disgenet	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQA1	Unknown	19525955 20453840 20598377 23472185 27386562 37377963	Disgenet, GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQA2	Unknown	37377963	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQB1	Unknown	23472185 37377963	CTD, Disgenet, GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQB3	Unknown	23472185 37377963	GWAS catalog	—
		HLA-DRA	Unknown	17660530 19525953 20159113 22190364 23472185	CTD, Disgenet, GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DRB1	Unknown	19525955 20598377 23472185 25911099	CTD, Disgenet, GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DRB3	Unknown	—	Disgenet	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DRB5	Unknown	39024449	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-F	Unknown	19525953	GWAS catalog	Endocytosis Phagosome Cellular senescence +21 more
		HMGN4	Unknown	37377963	GWAS catalog	—
		HORMAD1	Unknown	31604244	GWAS catalog	—
		HOXA1	Unknown	31604244	GWAS catalog	Signaling pathways regulating pluripotency of stem cells
		HS3ST2	Unknown	19525955	GWAS catalog	Glycosaminoglycan biosynthesis - heparan sulfate / heparin HS-GAG biosynthesis
		HSP90AB1	Unknown	—	Disgenet	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +26 more
		HTR3A	Unknown	31604244	GWAS catalog	Serotonergic synapse Taste transduction Neurotransmitter receptors and postsynaptic signal transmission
		ICAM1	Unknown	20175758	CTD, Disgenet	NF-kappa B signaling pathway Cell adhesion molecules Natural killer cell mediated cytotoxicity +19 more
		IFI30	Unknown	24076602 31604244	GWAS catalog	Antigen processing and presentation MHC class II antigen presentation Interferon gamma signaling
		IFITM3	Unknown	31604244	GWAS catalog	Interferon alpha/beta signaling
		IFNAR1	Unknown	31604244	GWAS catalog	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway Necroptosis +17 more
		IFNB1	Unknown	10520943 12424511 12432978 23517930 27806875	CTD, Disgenet	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway Necroptosis +31 more
		IFNG	Unknown	23517930	CTD, Disgenet	Proteasome Cytokine-cytokine receptor interaction HIF-1 signaling pathway +33 more
		IFNGR2	Unknown	24076602 31604244	GWAS catalog	Cytokine-cytokine receptor interaction HIF-1 signaling pathway Necroptosis +16 more
		IGF2R	Unknown	19010793	GWAS catalog	Virion - Herpesvirus Lysosome Endocytosis +5 more
		IKZF1	Unknown	24076602 31604244 38616254	GWAS catalog	—
		IKZF2	Unknown	31604244	GWAS catalog	—
		IKZF3	Unknown	24076602 31604244	GWAS catalog	—
		IL10	Unknown	23517930	CTD, Disgenet	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor FoxO signaling pathway +25 more
		IL10RB	Unknown	31604244	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor JAK-STAT signaling pathway +6 more
		IL12A	Unknown	21833088 24076602 31604244	CTD, Disgenet, GWAS catalog	Cytokine-cytokine receptor interaction Toll-like receptor signaling pathway RIG-I-like receptor signaling pathway +26 more
		IL17A	Unknown	23517930	CTD, Disgenet	Cytokine-cytokine receptor interaction IL-17 signaling pathway Th17 cell differentiation +5 more
		IL1B	Unknown	15210533 25458313	CTD, Disgenet	Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +47 more
		IL1RN	Unknown	25458313	CTD, Disgenet	Cytokine-cytokine receptor interaction Interleukin-10 signaling Interleukin-1 signaling
		IL20RA	Unknown	21833088 24076602 31604244 40262193	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor JAK-STAT signaling pathway +1 more
		IL21R	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +2 more
		IL22RA2	Unknown	21833088 24076602 31604244 40262193	GWAS catalog	JAK-STAT signaling pathway Interleukin-20 family signaling
		IL23R	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +4 more
		IL2RA	Unknown	17660530 19119414 19525955 24076602 19525953 21833088 22190364 26819262 28445677 31407831 31604244	CTD, Disgenet, GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Endocytosis +12 more
		IL4	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway +15 more
		IL4R	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway +6 more
		IL6	Unknown	31604244	Disgenet, GWAS catalog	EGFR tyrosine kinase inhibitor resistance Antifolate resistance Cytokine-cytokine receptor interaction +59 more
		IL7	Unknown	17660816 38616254	CTD, Disgenet, GWAS catalog	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway +3 more
		IL7R	Unknown	17660530 17660816 17660817 19525955 19525953 21833088 24076602 31604244 40262193	CTD, Disgenet, GWAS catalog	Cytokine-cytokine receptor interaction FoxO signaling pathway PI3K-Akt signaling pathway +7 more
		INAVA	Unknown	21833088 24076602 31604244 40262193	GWAS catalog	—
		IP6K3	Unknown	26920376	GWAS catalog	Phosphatidylinositol signaling system Synthesis of pyrophosphates in the cytosol
		IQCB1	Unknown	24076602 26920376 31604244	GWAS catalog	Anchoring of the basal body to the plasma membrane
		IQGAP1	Unknown	24076602	GWAS catalog	Adherens junction Regulation of actin cytoskeleton Proteoglycans in cancer +9 more
MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO	MONDO:0007462PS126200	HLA-DQB1	Unknown	—	ClinVar	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more

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Multiple sclerosis

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