Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
MULTIPLE SCLEROSIS	MONDO_0005301 C0026769 MESH:D009103	EVI5	Unknown	21833088 24076602 26819262 31604244 40262193	GWAS catalog	—
		EXOC2	Unknown	31604244	GWAS catalog	Ras signaling pathway Salmonella infection Insulin processing +1 more
		EXOC6	Unknown	21833088 24076602 31604244 40262193	GWAS catalog	Insulin processing VxPx cargo-targeting to cilium
		EXTL2	Unknown	21833088 24076602 40262193	GWAS catalog	Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways XBP1(S) activates chaperone genes
		FAM167A	Unknown	24076602 31604244	GWAS catalog	—
		FAM221B	Unknown	31604244	GWAS catalog	—
		FAM241A	Unknown	31604244	GWAS catalog	—
		FAM47B	Unknown	23412934	GWAS catalog	—
		FAM76B	Unknown	21833088 26920376 31604244	GWAS catalog	—
		FAS	Unknown	—	Disgenet	Platinum drug resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +36 more
		FASLG	Unknown	31068361	CTD, Disgenet	Platinum drug resistance MAPK signaling pathway Ras signaling pathway +38 more
		FCRL1	Unknown	24076602	GWAS catalog	—
		FCRL3	Unknown	21833088 26920376 31604244	GWAS catalog	—
		FLI1	Unknown	31604244	GWAS catalog	Transcriptional misregulation in cancer
		FOXO3	Unknown	19010793	GWAS catalog	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway FoxO signaling pathway +26 more
		FOXP1	Unknown	24076602 31604244	GWAS catalog	MicroRNAs in cancer Transcriptional regulation of pluripotent stem cells
		FPR1	Unknown	24076602 31604244	GWAS catalog	Rap1 signaling pathway Neuroactive ligand-receptor interaction Neutrophil extracellular trap formation +5 more
		FUT2	Unknown	21833088	GWAS catalog	Glycosphingolipid biosynthesis - lacto and neolacto series Glycosphingolipid biosynthesis - globo and isoglobo series Metabolic pathways +2 more
		FUT8	Unknown	20802204	GWAS catalog	N-Glycan biosynthesis Various types of N-glycan biosynthesis Glycosaminoglycan biosynthesis - keratan sulfate +3 more
		GABRA3	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Retrograde endocannabinoid signaling GABAergic synapse +4 more
		GALC	Unknown	24076602 31604244	GWAS catalog	Sphingolipid metabolism Metabolic pathways Lysosome +1 more
		GARIN3	Unknown	31604244	GWAS catalog	—
		GATA3	Unknown	31604244 38616254	GWAS catalog	Th1 and Th2 cell differentiation Th17 cell differentiation Parathyroid hormone synthesis, secretion and action +6 more
		GC	Unknown	25590278	CTD, Disgenet	Vitamin D (calciferol) metabolism
		GCFC2	Unknown	33296963	GWAS catalog	mRNA Splicing - Major Pathway
		GCG	Unknown	31604244	GWAS catalog	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +11 more
		GFI1	Unknown	26920376 27386562 31604244	GWAS catalog	—
		GIMAP2	Unknown	31604244	GWAS catalog	—
		GIMAP6	Unknown	31604244	GWAS catalog	—
		GLB1	Unknown	24076602	GWAS catalog	Galactose metabolism Other glycan degradation Glycosaminoglycan degradation +11 more
		GLI3	Unknown	39024449	GWAS catalog	cAMP signaling pathway Hedgehog signaling pathway Pathways in cancer +5 more
		GNG2	Unknown	31604244	GWAS catalog	Ras signaling pathway Chemokine signaling pathway Hormone signaling +43 more
		GPC5	Unknown	19010793	GWAS catalog	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation +7 more
		GRAP2	Unknown	31604244	GWAS catalog	T cell receptor signaling pathway Signaling by SCF-KIT Generation of second messenger molecules +4 more
		GRB2	Unknown	31604244	GWAS catalog	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +129 more
		GRB7	Unknown	24076602	GWAS catalog	GRB7 events in ERBB2 signaling Signaling by SCF-KIT Downstream signal transduction +2 more
		GSTM1	Unknown	—	Disgenet	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +10 more
		GSTM3	Unknown	—	Disgenet	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +10 more
		GSTM5	Unknown	39024449	GWAS catalog	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +10 more
		GSTP1	Unknown	—	Disgenet	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +11 more
		GSTT1	Unknown	—	Disgenet	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +10 more
		GTF2H4	Unknown	37377963	GWAS catalog	Basal transcription factors Nucleotide excision repair Viral carcinogenesis +20 more
		H2BC15	Unknown	37377963	GWAS catalog	Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis +31 more
		H6PD	Unknown	—	Disgenet	Pentose phosphate pathway Metabolic pathways Carbon metabolism
		HACE1	Unknown	23412934	GWAS catalog	Antigen processing: Ubiquitination & Proteasome degradation
		HBS1L	Unknown	21833088 31604244 38616254	GWAS catalog	mRNA surveillance pathway Legionellosis mRNA decay by 3' to 5' exoribonuclease
		HDGFL2	Unknown	31604244	GWAS catalog	—
		HIC1	Unknown	31604244	GWAS catalog	SUMOylation of transcription factors
		HLA-B	Unknown	37377963	GWAS catalog	Endocytosis Phagosome Cellular senescence +24 more
		HLA-DMB	Unknown	37377963	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +22 more
MULTIPLE SCLEROSIS, RELAPSING-REMITTING	C0751967	FAS	Unknown	—	Disgenet	Platinum drug resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +36 more

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Multiple sclerosis

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