Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
CROHN'S DISEASE	EFO_0000384	NCR3	Unknown	22936669	GWAS catalog	Natural killer cell mediated cytotoxicity Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
		NDFIP1	Unknown	21102463 23128233 26192919 26974007 28067908 37156999 37262302	GWAS catalog	—
		NEK5	Unknown	37156999	GWAS catalog	—
		NELL1	Unknown	17684544	GWAS catalog	—
		NFATC1	Unknown	26192919 26974007	GWAS catalog	MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +26 more
		NFKB1	Unknown	26974007	GWAS catalog	Antifolate resistance MAPK signaling pathway Ras signaling pathway +96 more
		NFKBIA	Unknown	37156999 37523193	GWAS catalog	cAMP signaling pathway Chemokine signaling pathway NF-kappa B signaling pathway +58 more
		NFKBIZ	Unknown	37156999	GWAS catalog	Transcriptional misregulation in cancer
		NKD1	Unknown	26301688 26974007 33686288 39024449	GWAS catalog	Wnt signaling pathway Hippo signaling pathway
		NLRP1	Unknown	30801121	GWAS catalog	NOD-like receptor signaling pathway The NLRP1 inflammasome
		NMT1	Unknown	39024449	GWAS catalog	Late Phase of HIV Life Cycle Inactivation, recovery and regulation of the phototransduction cascade Activation, myristolyation of BID and translocation to mitochondria
		NOL4L	Unknown	37156999	GWAS catalog	—
		NOS2	Unknown	26974007	GWAS catalog	Arginine biosynthesis Arginine and proline metabolism Metabolic pathways +21 more
		NOTCH1	Unknown	26192919 26974007	GWAS catalog	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	23128233 37156999	GWAS catalog	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NOTCH4	Unknown	23266558 37262302 38154582	GWAS catalog	Endocrine resistance Notch signaling pathway Thyroid hormone signaling pathway +11 more
		NPEPPS	Unknown	26974007	GWAS catalog	Antigen processing: Ubiquitination & Proteasome degradation
		NPIPB6	Unknown	26301688	GWAS catalog	—
		NR5A2	Unknown	26192919 26974007 28067908 37156999	GWAS catalog	Maturity onset diabetes of the young Nuclear Receptor transcription pathway SUMOylation of intracellular receptors +1 more
		NRBP1	Unknown	23128233	GWAS catalog	Nuclear Receptor transcription pathway
		NRP1	Unknown	30801121	GWAS catalog	Axon guidance Human T-cell leukemia virus 1 infection Coronavirus disease - COVID-19 +5 more
		NRXN3	Unknown	35232999	GWAS catalog	Cell adhesion molecules Neurexins and neuroligins
		NUCB2	Unknown	37156999	GWAS catalog	—
		NUDT12	Unknown	35232999	GWAS catalog	Nicotinate and nicotinamide metabolism Metabolic pathways Peroxisome +1 more
		NUPR1	Unknown	28067908 35512355 37156999 37523193	GWAS catalog	Transcriptional misregulation in cancer
		NXPE1	Unknown	26192919 26974007 28067908 37156999	GWAS catalog	—
		OPCML	Unknown	30801121	GWAS catalog	Post-translational modification: synthesis of GPI-anchored proteins
		OR5B21	Unknown	26974007	GWAS catalog	Olfactory transduction Olfactory Signaling Pathway
		OSMR	Unknown	26192919 26974007 28067908 37156999	GWAS catalog	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway +1 more
		OTUD1	Unknown	18723019	GWAS catalog	—
		OTUD3	Unknown	26192919 26974007 28067908 33608531 33686288 37156999	GWAS catalog	Ovarian tumor domain proteases Regulation of PTEN stability and activity
		P4HA2	Unknown	33608531	GWAS catalog	Arginine and proline metabolism Metabolic pathways Collagen biosynthesis and modifying enzymes
		PARK7	Unknown	23128233 26192919 26974007 28067908 37523193	GWAS catalog	Parkinson disease Pathways of neurodegeneration - multiple diseases SUMOylation of transcription cofactors +1 more
		PCSK5	Unknown	27569725	GWAS catalog	NGF processing Assembly of active LPL and LIPC lipase complexes
		PDE4A	Unknown	26301688	GWAS catalog	Purine metabolism Metabolic pathways cAMP signaling pathway +4 more
		PDGFB	Unknown	21102463 23128233 26192919 26974007 28067908 33686288 37156999	GWAS catalog	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +25 more
		PDK1	Unknown	37156999	GWAS catalog	HIF-1 signaling pathway Central carbon metabolism in cancer Regulation of pyruvate dehydrogenase (PDH) complex +1 more
		PDLIM4	Unknown	33608531	GWAS catalog	Cytoskeleton in muscle cells
		PER3	Unknown	21102463	GWAS catalog	Circadian rhythm Circadian entrainment
		PGAP3	Unknown	37262302	GWAS catalog	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Metabolic pathways
		PHACTR2	Unknown	23128233 26192919 37156999	GWAS catalog	Platelet degranulation
		PHC2	Unknown	37156999	GWAS catalog	Polycomb repressive complex Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins +5 more
		PHLDB2	Unknown	25557950	GWAS catalog	—
		PHTF1	Unknown	23128233 26301688	GWAS catalog	—
		PIK3R1	Unknown	32581322	GWAS catalog	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		PKD1	Unknown	37156999	GWAS catalog	VxPx cargo-targeting to cilium
		PKIG	Unknown	26974007	GWAS catalog	—
		PLA2G2D	Unknown	32581322	GWAS catalog	Glycerophospholipid metabolism Ether lipid metabolism Arachidonic acid metabolism +13 more
		PLA2G4A	Unknown	26192919 37156999	GWAS catalog	Glycerophospholipid metabolism Ether lipid metabolism Arachidonic acid metabolism +33 more
		PLA2G5	Unknown	32581322	GWAS catalog	Glycerophospholipid metabolism Ether lipid metabolism Arachidonic acid metabolism +13 more
PERIANAL CROHN'S DISEASE	EFO_0005627	PHLDB2	Unknown	25557950	GWAS catalog	—

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Crohn disease

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