Crohn disease | Gene-Disease Associations & Pathways | GeDiPNet

GeDiPNet

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Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
CROHN'S DISEASE	EFO_0000384	VSTM2B	Unknown	32581322	GWAS catalog	—
		VSX2	Unknown	28008999	GWAS catalog	—
		VWF	Unknown	39024449	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +20 more
		WWOX	Unknown	37156999	GWAS catalog	Nuclear signaling by ERBB4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors
		XPO1	Unknown	37262302	GWAS catalog	Ribosome biogenesis in eukaryotes Nucleocytoplasmic transport Viral life cycle - HIV-1 +15 more
		YDJC	Unknown	37156999	GWAS catalog	—
		ZBTB38	Unknown	26192919 28067908 37156999 37523193	GWAS catalog	—
		ZBTB40	Unknown	23128233 26192919 26974007 28067908 33608531 37156999	GWAS catalog	—
		ZBTB46	Unknown	37523193	GWAS catalog	—
		ZBTB9	Unknown	32024964	GWAS catalog	—
		ZC3H13	Unknown	35232999	GWAS catalog	—
		ZCCHC7	Unknown	38154582	GWAS catalog	RNA degradation
		ZDHHC23	Unknown	22482804	GWAS catalog	—
		ZFP1	Unknown	23665963	GWAS catalog	Generic Transcription Pathway
		ZFP36L1	Unknown	21102463 23128233 26192919 37156999	GWAS catalog	Cellular senescence Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
		ZFP90	Unknown	37156999	GWAS catalog	Generic Transcription Pathway
		ZGPAT	Unknown	18758464 21102463 23128233 26192919	GWAS catalog	—
		ZHX3	Unknown	37156999	GWAS catalog	—
		ZMIZ1	Unknown	21102463 22482804 23128233 25489960 26192919 26301688 26974007 28067908 33686288 37156999	GWAS catalog	—
		ZNF300	Unknown	23128233 26192919 28067908 37156999	GWAS catalog	Generic Transcription Pathway
		ZNF568	Unknown	37156999	GWAS catalog	Generic Transcription Pathway
		ZNF831	Unknown	23128233 26192919 26974007 28067908 37156999	GWAS catalog	—
		ZPBP2	Unknown	18587394 21102463 26192919 26301688 26974007	GWAS catalog	—
CROHNS DISEASE OF LARGE BOWEL	C0156147	ABCB1	Unknown	—	Disgenet	ABC transporters Bile secretion MicroRNAs in cancer +2 more
		BPI	Unknown	—	Disgenet	Toll Like Receptor 4 (TLR4) Cascade Neutrophil degranulation Antimicrobial peptides
		CLDN1	Unknown	—	Disgenet	Virion - Hepatitis viruses Cell adhesion molecules Tight junction +3 more
		FCGR3A	Unknown	—	Disgenet	Phagosome Osteoclast differentiation Neutrophil extracellular trap formation +12 more
		GC	Unknown	—	Disgenet	Vitamin D (calciferol) metabolism
		GSTM1	Unknown	—	Disgenet	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +10 more
		GSTT1	Unknown	—	Disgenet	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +10 more
		HFE	Unknown	—	Disgenet	TGF-beta signaling pathway Transferrin endocytosis and recycling
		HLA-DPA1	Unknown	—	Disgenet	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		ICAM1	Unknown	—	Disgenet	NF-kappa B signaling pathway Cell adhesion molecules Natural killer cell mediated cytotoxicity +19 more
		MBL2	Unknown	—	Disgenet	Phagosome Complement and coagulation cascades Staphylococcus aureus infection +3 more
		MKI67	Unknown	—	Disgenet	—
		OCLN	Unknown	—	Disgenet	Virion - Hepatitis viruses Cell adhesion molecules Tight junction +5 more
		PRF1	Unknown	—	Disgenet	Apoptosis Natural killer cell mediated cytotoxicity Type I diabetes mellitus +4 more
		SELL	Unknown	—	Disgenet	Cell adhesion molecules Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall +1 more
		UGT1A1	Unknown	—	Disgenet	Pentose and glucuronate interconversions Ascorbate and aldarate metabolism Steroid hormone biosynthesis +12 more

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