Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
CROHN'S DISEASE	EFO_0000384	TC2N	Unknown	35232999	GWAS catalog	—
		TCERG1L	Unknown	22412388	GWAS catalog	—
		TENM3	Unknown	26301688	GWAS catalog	—
		TET2	Unknown	26192919 37156999	GWAS catalog	—
		TEX48	Unknown	23266558	GWAS catalog	—
		TGFBR2	Unknown	37156999	GWAS catalog	MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway +28 more
		TGFBR3	Unknown	37156999	GWAS catalog	—
		THADA	Unknown	21102463 23128233 26192919 26974007 28067908 37156999	GWAS catalog	tRNA modification in the nucleus and cytosol
		THEMIS	Unknown	23128233 26192919 26974007 28067908 37156999	GWAS catalog	—
		THSD7A	Unknown	32581322	GWAS catalog	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		TIMD4	Unknown	37156999	GWAS catalog	Efferocytosis
		TM9SF4	Unknown	23128233 28067908	GWAS catalog	—
		TMBIM1	Unknown	23128233 26192919 28067908	GWAS catalog	Neutrophil degranulation
		TMCO4	Unknown	26974007	GWAS catalog	—
		TMEM106B	Unknown	32581322	GWAS catalog	—
		TMEM117	Unknown	27569725	GWAS catalog	—
		TMEM151B	Unknown	37156999	GWAS catalog	—
		TMEM170A	Unknown	37156999	GWAS catalog	—
		TMEM174	Unknown	21102463 23128233 26192919 26974007 28067908 37156999 37262302	GWAS catalog	—
		TMEM258	Unknown	21102463 26192919 26974007 33686288 37156999	GWAS catalog	N-Glycan biosynthesis Various types of N-glycan biosynthesis Protein processing in endoplasmic reticulum
		TNFAIP3	Unknown	26974007	GWAS catalog	NF-kappa B signaling pathway Necroptosis NOD-like receptor signaling pathway +10 more
		TNFRSF14	Unknown	26192919 26974007 28067908 37156999	GWAS catalog	Virion - Herpesvirus Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor +3 more
		TNFRSF1A	Unknown	26974007	GWAS catalog	MAPK signaling pathway Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor +39 more
		TNFRSF6B	Unknown	26192919 26974007 28067908 37156999	GWAS catalog	Cytokine-cytokine receptor interaction TNFs bind their physiological receptors
		TNFSF18	Unknown	17554261 18587394 23128233 33686288	GWAS catalog	Cytokine-cytokine receptor interaction TNFs bind their physiological receptors
		TNFSF8	Unknown	37262302	GWAS catalog	Cytokine-cytokine receptor interaction TNFs bind their physiological receptors
		TNIP1	Unknown	26974007	GWAS catalog	Shigellosis Ovarian tumor domain proteases
		TNRC18	Unknown	37156999	GWAS catalog	—
		TNXB	Unknown	37262302	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +3 more
		TOM1	Unknown	28067908	GWAS catalog	Neutrophil degranulation
		TRAF3IP2	Unknown	26192919 37156999	GWAS catalog	Cellular senescence IL-17 signaling pathway
		TRAPPC10	Unknown	37156999	GWAS catalog	COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs
		TRIM40	Unknown	38154582	GWAS catalog	—
		TRPM3	Unknown	32581322	GWAS catalog	TRP channels
		TRPS1	Unknown	37156999	GWAS catalog	—
		TSBP1	Unknown	39024449	GWAS catalog	—
		TSHZ2	Unknown	32581322	GWAS catalog	—
		TSPAN14	Unknown	23128233 26192919 26974007 28067908 33686288 37156999	GWAS catalog	Neutrophil degranulation Amyloid fiber formation
		TTC33	Unknown	17447842 17554261 17554300 17684544 18587394 21102463 22412388 22936669 23128233 26192919 26278503 26301688 26974007 28067908 33600772 33608531 33686288 37156999 37523193 39024449	GWAS catalog	—
		TUBD1	Unknown	23128233 26192919 28067908 37156999	GWAS catalog	Motor proteins
		TWF1	Unknown	27569725	GWAS catalog	—
		UBAC2	Unknown	23128233 26192919 26974007 28067908 37156999	GWAS catalog	—
		UBASH3A	Unknown	26974007 37262302	GWAS catalog	—
		UBE2L3	Unknown	21102463 23128233 26192919 26974007 28067908 37156999 37523193	GWAS catalog	Ubiquitin mediated proteolysis Parkinson disease Pathways of neurodegeneration - multiple diseases +3 more
		UBE2V2	Unknown	26192919 28067908 37156999	GWAS catalog	Shigellosis Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) +5 more
		UBE3D	Unknown	26891255	GWAS catalog	Antigen processing: Ubiquitination & Proteasome degradation
		UBR4	Unknown	35232999	GWAS catalog	Human papillomavirus infection Viral carcinogenesis Neutrophil degranulation +1 more
		UQCR10	Unknown	26974007	GWAS catalog	Oxidative phosphorylation Metabolic pathways Cardiac muscle contraction +11 more
		USP1	Unknown	26192919	GWAS catalog	Fanconi anemia pathway Recognition of DNA damage by PCNA-containing replication complex Fanconi Anemia Pathway
		USP34	Unknown	37262302	GWAS catalog	TCF dependent signaling in response to WNT Ub-specific processing proteases

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Crohn disease

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