Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
CROHN'S DISEASE	EFO_0000384	SLC25A24	Unknown	37156999	GWAS catalog	—
		SLC25A28	Unknown	26301688 33686288 37262302 37523193	GWAS catalog	—
		SLC2A13	Unknown	26192919	GWAS catalog	Inositol transporters
		SLC34A1	Unknown	37156999 37262302	GWAS catalog	Parathyroid hormone synthesis, secretion and action Mineral absorption Type II Na+/Pi cotransporters +2 more
		SLC39A11	Unknown	26192919 26974007 28067908 37156999	GWAS catalog	Alzheimer disease Parkinson disease
		SLC39A8	Unknown	37156999	GWAS catalog	Ferroptosis Alzheimer disease Parkinson disease +1 more
		SLC43A3	Unknown	22412388	GWAS catalog	—
		SLC7A10	Unknown	21102463 23128233 26192919 28067908 37156999 38616254	GWAS catalog	Basigin interactions Amino acid transport across the plasma membrane
		SLC9A2	Unknown	35512355	GWAS catalog	Sodium/Proton exchangers
		SLC9A4	Unknown	23128233 26301688 35512355	GWAS catalog	Gastric acid secretion Sodium/Proton exchangers
		SLC9A8	Unknown	26974007	GWAS catalog	Sodium/Proton exchangers
		SMAD7	Unknown	23128233 26192919 28067908 37156999	GWAS catalog	TGF-beta signaling pathway Hippo signaling pathway Signaling by BMP +3 more
		SMARCE1	Unknown	37156999	GWAS catalog	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		SMCHD1	Unknown	37156999	GWAS catalog	—
		SMIM3	Unknown	17554261 33686288 39024449	GWAS catalog	—
		SMURF1	Unknown	23128233 26192919 26974007 28067908 37156999	GWAS catalog	Ubiquitin mediated proteolysis Mitophagy - animal Endocytosis +10 more
		SNAPC4	Unknown	33686288 37156999	GWAS catalog	RNA polymerase II transcribes snRNA genes RNA Polymerase III Transcription Initiation From Type 3 Promoter
		SNN	Unknown	26974007	GWAS catalog	—
		SNX20	Unknown	26974007 28008999 33686288 35512355	GWAS catalog	—
		SOCS1	Unknown	22482804	GWAS catalog	Ubiquitin mediated proteolysis Osteoclast differentiation JAK-STAT signaling pathway +13 more
		SORCS2	Unknown	30801121	GWAS catalog	—
		SOX5	Unknown	27569725	GWAS catalog	—
		SP140	Unknown	21102463 23128233 26192919 26974007 28067908 37156999	GWAS catalog	—
		SPATA31F1	Unknown	26974007	GWAS catalog	—
		SPATA31H1	Unknown	37262302	GWAS catalog	—
		SPATC1	Unknown	37156999	GWAS catalog	—
		SPATS2L	Unknown	38154582	GWAS catalog	—
		SPDEF	Unknown	27569725	GWAS catalog	—
		SPMIP7	Unknown	18587394 21102463 23128233 26192919 26974007 28067908 37156999 37262302 37523193 38616254	GWAS catalog	—
		SPRED2	Unknown	37156999	GWAS catalog	Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants
		SPRY4	Unknown	37262302	GWAS catalog	—
		ST7	Unknown	23128233 28067908	GWAS catalog	—
		ST8SIA4	Unknown	30801121	GWAS catalog	Sialic acid metabolism NCAM1 interactions
		STAT3	Unknown	18587394 23128233 23266558 26192919 26278503 26974007 27569725 28067908 32024964 37156999 37523193	GWAS catalog	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway HIF-1 signaling pathway +53 more
		STAT4	Unknown	23128233 26192919 33686288	GWAS catalog	Necroptosis JAK-STAT signaling pathway Th1 and Th2 cell differentiation +9 more
		STAT5B	Unknown	37262302	GWAS catalog	ErbB signaling pathway Chemokine signaling pathway Hormone signaling +28 more
		STK10	Unknown	37156999	GWAS catalog	Progesterone-mediated oocyte maturation Neutrophil degranulation
		STK11	Unknown	26974007	GWAS catalog	FoxO signaling pathway Hormone signaling Autophagy - animal +9 more
		STMN3	Unknown	26301688	GWAS catalog	—
		SUB1	Unknown	39024449	GWAS catalog	—
		SUFU	Unknown	26192919	GWAS catalog	Hedgehog signaling pathway Pathways in cancer Basal cell carcinoma +4 more
		SULF1	Unknown	32581322	GWAS catalog	—
		SULT1A1	Unknown	38616254	GWAS catalog	Chemical carcinogenesis - DNA adducts Cytosolic sulfonation of small molecules
		SUOX	Unknown	26301688	GWAS catalog	Sulfur metabolism Metabolic pathways Sulfide oxidation to sulfate
		SYNDIG1L	Unknown	30801121	GWAS catalog	—
		SYNGR1	Unknown	26192919	GWAS catalog	Neutrophil degranulation
		SYPL1	Unknown	30801121	GWAS catalog	—
		SYVN1	Unknown	32581322	GWAS catalog	Ubiquitin mediated proteolysis Protein processing in endoplasmic reticulum XBP1(S) activates chaperone genes +3 more
		TAB2	Unknown	26192919 37156999	GWAS catalog	MAPK signaling pathway NF-kappa B signaling pathway Osteoclast differentiation +33 more
		TAGLN2	Unknown	25557950	GWAS catalog	Platelet degranulation
CROHNS DISEASE OF LARGE BOWEL	C0156147	STAT3	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway HIF-1 signaling pathway +53 more
PERIANAL CROHN'S DISEASE	EFO_0005627	TAGLN2	Unknown	25557950	GWAS catalog	Platelet degranulation

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Crohn disease

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