Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
CROHN'S DISEASE	EFO_0000384	PLA2R1	Unknown	26192919	GWAS catalog	Phagosome Tuberculosis Acyl chain remodelling of PC +5 more
		PLAU	Unknown	23128233 26192919 26974007 28067908	GWAS catalog	NF-kappa B signaling pathway Complement and coagulation cascades Transcriptional misregulation in cancer +5 more
		PLB1	Unknown	37156999	GWAS catalog	Glycerophospholipid metabolism Ether lipid metabolism Arachidonic acid metabolism +6 more
		PLCG2	Unknown	28067908 37156999	GWAS catalog	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +49 more
		PLCL1	Unknown	21102463 26192919 26974007 28067908 37156999	GWAS catalog	GABAergic synapse
		PLCXD2	Unknown	25557950	GWAS catalog	—
		PLPP3	Unknown	37156999	GWAS catalog	Glycerolipid metabolism Glycerophospholipid metabolism Ether lipid metabolism +7 more
		PLXNA2	Unknown	27569725	GWAS catalog	Axon guidance Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion +1 more
		PNKD	Unknown	23128233 26192919 28067908 37262302	GWAS catalog	—
		POFUT1	Unknown	26192919 26974007	GWAS catalog	Other types of O-glycan biosynthesis
		POP7	Unknown	23128233 37156999	GWAS catalog	Ribosome biogenesis in eukaryotes tRNA processing in the nucleus
		POU5F1	Unknown	23266558 37262302	GWAS catalog	Signaling pathways regulating pluripotency of stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation +1 more
		PPBP	Unknown	23128233	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +4 more
		PPM1G	Unknown	23128233	GWAS catalog	—
		PPP2R3C	Unknown	26974007	GWAS catalog	mRNA surveillance pathway Sphingolipid signaling pathway PI3K-Akt signaling pathway +5 more
		PPP5C	Unknown	23128233 26192919 26974007 28067908 37156999	GWAS catalog	MAPK signaling pathway Negative regulation of MAPK pathway Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks +1 more
		PRDM1	Unknown	18587394 21102463 23128233 26192919 26974007 28067908 37156999 37262302	GWAS catalog	Regulation of TP53 Expression
		PRDX5	Unknown	21102463 37156999	GWAS catalog	Peroxisome Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes
		PRKCB	Unknown	23128233 26192919 26974007 28067908 37156999	GWAS catalog	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +77 more
		PRORP	Unknown	37262302	GWAS catalog	tRNA processing in the mitochondrion tRNA modification in the mitochondrion rRNA processing in the mitochondrion
		PRR5L	Unknown	37156999	GWAS catalog	mTOR signaling pathway
		PRRC2A	Unknown	37262302	GWAS catalog	—
		PRXL2B	Unknown	26192919 28067908	GWAS catalog	Arachidonic acid metabolism Metabolic pathways
		PSEN2	Unknown	37156999	GWAS catalog	Notch signaling pathway Neurotrophin signaling pathway Alzheimer disease +9 more
		PSMA6	Unknown	26974007 37262302	GWAS catalog	Proteasome Alzheimer disease Parkinson disease +56 more
		PSMB10	Unknown	22412388	GWAS catalog	Proteasome Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha +49 more
		PSMD14	Unknown	30801121	GWAS catalog	Proteasome Alzheimer disease Parkinson disease +59 more
		PTCD2	Unknown	26192919 26974007	GWAS catalog	—
		PTGIR	Unknown	26192919	GWAS catalog	Neuroactive ligand-receptor interaction Vascular smooth muscle contraction Platelet activation +4 more
		PTK2B	Unknown	26192919 37156999	GWAS catalog	Calcium signaling pathway Chemokine signaling pathway Phospholipase D signaling pathway +10 more
		PTPN22	Unknown	18587394 21102463 26192919 26974007 33686288 37156999	GWAS catalog	Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse
		PTPRC	Unknown	26192919 28067908 37156999	GWAS catalog	Cell adhesion molecules T cell receptor signaling pathway Fc gamma R-mediated phagocytosis +5 more
		PTPRD	Unknown	30801121	GWAS catalog	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		PTPRK	Unknown	23128233 26192919 26974007 28067908 37156999	GWAS catalog	EGFR downregulation
		PUS10	Unknown	21102463 21298027 22412388 23128233 26192919 26974007 28067908 33608531 37156999	GWAS catalog	—
		PVALEF	Unknown	37156999	GWAS catalog	—
		PYGO2	Unknown	27569725 37156999 37523193	GWAS catalog	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
		RAD50	Unknown	37262302	GWAS catalog	Homologous recombination Non-homologous end-joining Cellular senescence +14 more
		RAD51AP2	Unknown	35232999	GWAS catalog	—
		RAP1A	Unknown	32581322	GWAS catalog	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +28 more
		RARB	Unknown	30801121	GWAS catalog	Pathways in cancer Small cell lung cancer Non-small cell lung cancer +3 more
		RASGRP1	Unknown	26192919	GWAS catalog	MAPK signaling pathway Ras signaling pathway Platelet activation +7 more
		RASIP1	Unknown	37262302	GWAS catalog	Adherens junction
		RAVER1	Unknown	26974007	GWAS catalog	—
		RBM43	Unknown	30801121	GWAS catalog	—
		RBMS2	Unknown	39024449	GWAS catalog	—
		RBMS3	Unknown	35232999	GWAS catalog	—
		RBPJ	Unknown	26192919	GWAS catalog	Notch signaling pathway Th1 and Th2 cell differentiation Spinocerebellar ataxia +12 more
		RBX1	Unknown	22936669	GWAS catalog	Nucleotide excision repair HIF-1 signaling pathway Cell cycle +36 more
		RDX	Unknown	26974007	GWAS catalog	Tight junction Regulation of actin cytoskeleton Proteoglycans in cancer +2 more
CROHNS DISEASE OF LARGE BOWEL	C0156147	PTPN22	Unknown	—	Disgenet	Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse
PERIANAL CROHN'S DISEASE	EFO_0005627	PLCXD2	Unknown	25557950	GWAS catalog	—

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Crohn disease

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