Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
CROHN'S DISEASE	EFO_0000384	IFIH1	Unknown	23128233 26192919 26974007 37156999 37262302	GWAS catalog	RIG-I-like receptor signaling pathway Hepatitis B Measles +11 more
		IFNGR2	Unknown	22936669 23128233 26192919 26974007 28067908 37156999	GWAS catalog	Cytokine-cytokine receptor interaction HIF-1 signaling pathway Necroptosis +16 more
		IFNLR1	Unknown	26974007	GWAS catalog	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Other interleukin signaling +1 more
		IFT81	Unknown	37156999	GWAS catalog	Intraflagellar transport
		IGF2	Unknown	26301688	GWAS catalog	MAPK signaling pathway Ras signaling pathway Hormone signaling +9 more
		IKZF1	Unknown	18587394 21102463 23128233 26192919 26974007 28067908 37156999 37262302 37523193 38616254	GWAS catalog	—
		IKZF3	Unknown	23128233 26192919 28067908 37156999	GWAS catalog	—
		IL12RB2	Unknown	32024964 35232999	GWAS catalog	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th1 and Th2 cell differentiation +4 more
		IL15RA	Unknown	26974007	GWAS catalog	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Intestinal immune network for IgA production +3 more
		IL17REL	Unknown	37156999	GWAS catalog	—
		IL18R1	Unknown	26192919 26974007 28067908 37156999	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor TNF signaling pathway +3 more
		IL18RAP	Unknown	21102463 23128233 26192919 26301688 37156999	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Inflammatory bowel disease +1 more
		IL19	Unknown	26974007	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor JAK-STAT signaling pathway +1 more
		IL1R1	Unknown	26192919 26974007	GWAS catalog	MAPK signaling pathway Cytokine-cytokine receptor interaction NF-kappa B signaling pathway +12 more
		IL1R2	Unknown	26192919 26974007	GWAS catalog	Cytokine-cytokine receptor interaction Hematopoietic cell lineage Amoebiasis +6 more
		IL1RL1	Unknown	28067908	GWAS catalog	Cytokine-cytokine receptor interaction PIP3 activates AKT signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling +1 more
		IL2	Unknown	26974007 28067908 37156999	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor PI3K-Akt signaling pathway +21 more
		IL21	Unknown	26974007 37156999	GWAS catalog	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +2 more
		IL21R	Unknown	37156999	GWAS catalog	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +2 more
		IL27	Unknown	23128233 26192919 26974007 28067908 30500874 32581322 35512355 37156999 37523193	GWAS catalog	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +1 more
		IL3	Unknown	22412388	GWAS catalog	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway Apoptosis +11 more
		IL4R	Unknown	37156999	GWAS catalog	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway +6 more
		IL6R	Unknown	26974007	GWAS catalog	EGFR tyrosine kinase inhibitor resistance Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor +13 more
		IMPG2	Unknown	28067908 37156999	GWAS catalog	—
		INAVA	Unknown	21102463 23128233 26192919 26974007 28067908 33608531 37156999	GWAS catalog	—
		INKA2	Unknown	30500874	GWAS catalog	—
		INS-IGF2	Unknown	26301688	GWAS catalog	—
		INTS11	Unknown	23128233 26192919 28067908	GWAS catalog	RNA polymerase II transcribes snRNA genes
		IPMK	Unknown	21102463 23128233 26192919 28067908 37156999	GWAS catalog	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system +1 more
		IPPK	Unknown	37156999	GWAS catalog	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system +2 more
		IQCH	Unknown	38154582	GWAS catalog	—
		IRF1	Unknown	21102463 26192919 26301688 26974007 32024964 33686288 38616254	GWAS catalog	C-type lectin receptor signaling pathway TNF signaling pathway Prolactin signaling pathway +5 more
		IRF2BP2	Unknown	37156999	GWAS catalog	—
		IRF4	Unknown	26192919	GWAS catalog	Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +1 more
		IRF5	Unknown	26192919 26974007 33608531 37156999	GWAS catalog	Toll-like receptor signaling pathway Interferon gamma signaling Interferon alpha/beta signaling
		IRF6	Unknown	28067908 37156999	GWAS catalog	Interferon gamma signaling Interferon alpha/beta signaling
		ITGA4	Unknown	28067908 33608531 37156999	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +16 more
		ITGAL	Unknown	26974007	GWAS catalog	Rap1 signaling pathway Cell adhesion molecules Neutrophil extracellular trap formation +14 more
		ITGAV	Unknown	37156999	GWAS catalog	Hormone signaling Phagosome Efferocytosis +26 more
		ITGB3	Unknown	37156999	GWAS catalog	Virion - Herpesvirus Rap1 signaling pathway Hormone signaling +39 more
		ITGB8	Unknown	28067908 37156999	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +9 more
		ITLN1	Unknown	18587394 23128233 26192919 26974007 28067908	GWAS catalog	Antimicrobial peptides
		JAK2	Unknown	18587394 21102463 23128233 23266558 26192919 26301688 26974007 28067908 35232999 37156999	GWAS catalog	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		JAZF1	Unknown	23128233 26192919 26974007 37156999	GWAS catalog	—
		KAT2A	Unknown	26278503	GWAS catalog	Viral life cycle - HIV-1 Notch signaling pathway Thyroid hormone signaling pathway +12 more
		KEAP1	Unknown	26301688 26974007	GWAS catalog	Ubiquitin mediated proteolysis Parkinson disease Pathways in cancer +6 more
		KIF21B	Unknown	18587394	GWAS catalog	Motor proteins COPI-dependent Golgi-to-ER retrograde traffic Kinesins
		KIF3B	Unknown	26192919 26974007	GWAS catalog	Motor proteins MHC class II antigen presentation Intraflagellar transport +2 more
		KIR3DL2	Unknown	26192919	GWAS catalog	Antigen processing and presentation Natural killer cell mediated cytotoxicity Graft-versus-host disease +1 more
		KLF6	Unknown	17554300	GWAS catalog	—
CROHNS DISEASE OF LARGE BOWEL	C0156147	IL21R	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +2 more
CROHNS DISEASE OF LARGE BOWEL	C0156147	JAK2	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more

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Crohn disease

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