Bipolar disorder

Nucleocytoplasmic transport snRNP Assembly RNA polymerase II transcribes snRNA genes

Condensation of Prophase Chromosomes HDMs demethylate histones

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Metabolic pathways Synthesis of glycosylphosphatidylinositol (GPI)

Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system Salmonella infection Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis +7 more

Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system Autophagy - other Autophagy - animal Phagosome Apelin signaling pathway Alzheimer disease Amyotrophic lateral sclerosis Huntington disease Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Shigellosis Salmonella infection Tuberculosis Kaposi sarcoma-associated herpesvirus infection PI3K Cascade Macroautophagy Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Toll Like Receptor 9 (TLR9) Cascade RHO GTPases Activate NADPH Oxidases +20 more

JAK-STAT signaling pathway AGE-RAGE signaling pathway in diabetic complications Pathways in cancer MicroRNAs in cancer Acute myeloid leukemia Interleukin-4 and Interleukin-13 signaling +3 more

Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system Regulation of actin cytoskeleton Synthesis of PIPs at the plasma membrane PI5P Regulates TP53 Acetylation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Synthesis of PIPs in the nucleus +5 more

Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system Regulation of actin cytoskeleton Synthesis of PIPs at the plasma membrane PI5P Regulates TP53 Acetylation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Synthesis of PIPs in the nucleus +5 more

Glycine, serine and threonine metabolism Lysine degradation Metabolic pathways Peroxisome Lysine catabolism Peroxisomal protein import +3 more

Antigen processing: Ubiquitination & Proteasome degradation

Glycerophospholipid metabolism Ether lipid metabolism Arachidonic acid metabolism Linoleic acid metabolism alpha-Linolenic acid metabolism Metabolic pathways Ras signaling pathway Vascular smooth muscle contraction Pancreatic secretion Fat digestion and absorption Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA +13 more

Glycerophospholipid metabolism Ether lipid metabolism Arachidonic acid metabolism Linoleic acid metabolism alpha-Linolenic acid metabolism Metabolic pathways Ras signaling pathway Vascular smooth muscle contraction Pancreatic secretion Fat digestion and absorption Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA Antimicrobial peptides +14 more

Glycerophospholipid metabolism Ether lipid metabolism Arachidonic acid metabolism Linoleic acid metabolism alpha-Linolenic acid metabolism Metabolic pathways MAPK signaling pathway Ras signaling pathway Phospholipase D signaling pathway Necroptosis Vascular smooth muscle contraction VEGF signaling pathway Platelet activation Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Glutamatergic synapse Serotonergic synapse Long-term depression Inflammatory mediator regulation of TRP channels GnRH signaling pathway Ovarian steroidogenesis Oxytocin signaling pathway Choline metabolism in cancer phospho-PLA2 pathway Acyl chain remodelling of PC Acyl chain remodeling of CL Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Hydrolysis of LPC Synthesis of PA Arachidonic acid metabolism ADP signalling through P2Y purinoceptor 1 Platelet sensitization by LDL COPI-independent Golgi-to-ER retrograde traffic +33 more

Glycerophospholipid metabolism Ether lipid metabolism Arachidonic acid metabolism Linoleic acid metabolism alpha-Linolenic acid metabolism Metabolic pathways Ras signaling pathway Efferocytosis Vascular smooth muscle contraction Fc gamma R-mediated phagocytosis Inflammatory mediator regulation of TRP channels Acyl chain remodelling of PC Acyl chain remodelling of PE Role of phospholipids in phagocytosis COPI-independent Golgi-to-ER retrograde traffic +12 more

Inositol phosphate metabolism Metabolic pathways Rap1 signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway Chemokine signaling pathway Phosphatidylinositol signaling system Sphingolipid signaling pathway Phospholipase D signaling pathway Hormone signaling Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Wnt signaling pathway Apelin signaling pathway Gap junction Platelet activation Neutrophil extracellular trap formation NOD-like receptor signaling pathway Circadian entrainment Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse Dopaminergic synapse Long-term depression Taste transduction Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Estrogen signaling pathway Melanogenesis Thyroid hormone synthesis Thyroid hormone signaling pathway Oxytocin signaling pathway Glucagon signaling pathway Renin secretion Aldosterone synthesis and secretion Relaxin signaling pathway Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action GnRH secretion AGE-RAGE signaling pathway in diabetic complications Cushing syndrome Growth hormone synthesis, secretion and action Endocrine and other factor-regulated calcium reabsorption Salivary secretion Gastric acid secretion Pancreatic secretion Carbohydrate digestion and absorption Alzheimer disease Huntington disease Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Shigellosis Chagas disease African trypanosomiasis Amoebiasis Human cytomegalovirus infection Pathways in cancer Diabetic cardiomyopathy Lipid and atherosclerosis PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors +67 more

Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway Chemokine signaling pathway NF-kappa B signaling pathway HIF-1 signaling pathway Phosphatidylinositol signaling system Phospholipase D signaling pathway Axon guidance VEGF signaling pathway Neutrophil extracellular trap formation Natural killer cell mediated cytotoxicity Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Neurotrophin signaling pathway Inflammatory mediator regulation of TRP channels Thyroid hormone signaling pathway AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Parkinson disease Pathways of neurodegeneration - multiple diseases Vibrio cholerae infection Epithelial cell signaling in Helicobacter pylori infection Shigellosis Yersinia infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Glioma Non-small cell lung cancer Hepatocellular carcinoma Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Lipid and atherosclerosis ISG15 antiviral mechanism Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Synthesis of IP3 and IP4 in the cytosol Downstream signal transduction Generation of second messenger molecules Role of phospholipids in phagocytosis PECAM1 interactions EGFR interacts with phospholipase C-gamma DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization VEGFR2 mediated cell proliferation Constitutive Signaling by EGFRvIII Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 point mutants in cancer RET signaling Activated NTRK2 signals through PLCG1 Activated NTRK3 signals through PLCG1 FCGR3A-mediated IL10 synthesis Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants +70 more

GABAergic synapse

Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins Type I hemidesmosome assembly +1 more

Glycerolipid metabolism Glycerophospholipid metabolism Role of phospholipids in phagocytosis

Axon guidance Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling +1 more

Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events +2 more

Terpenoid backbone biosynthesis Metabolic pathways Peroxisome Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP) +2 more

Base excision repair

RNA polymerase

RNA polymerase Cytosolic DNA-sensing pathway Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter +3 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Estrogen signaling pathway Melanogenesis Adipocytokine signaling pathway Aldosterone synthesis and secretion Cortisol synthesis and secretion Cushing syndrome Opioid Signalling Androgen biosynthesis Glucocorticoid biosynthesis G-protein activation Peptide hormone biosynthesis Endogenous sterols Peptide ligand-binding receptors G alpha (s) signalling events G alpha (i) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Interleukin-4 and Interleukin-13 signaling ADORA2B mediated anti-inflammatory cytokines production +18 more

Mannose type O-glycan biosynthesis Metabolic pathways O-linked glycosylation

Synthesis of 5-eicosatetraenoic acids

EGR2 and SOX10-mediated initiation of Schwann cell myelination

PPAR signaling pathway Efferocytosis Wnt signaling pathway Pathways in cancer Acute myeloid leukemia Carnitine metabolism Regulation of pyruvate dehydrogenase (PDH) complex Nuclear Receptor transcription pathway Signaling by Retinoic Acid +6 more

Necroptosis Cellular senescence Alzheimer disease Pathways of neurodegeneration - multiple diseases Shigellosis ESR-mediated signaling +3 more

mRNA surveillance pathway cGMP-PKG signaling pathway cAMP signaling pathway Oocyte meiosis Cellular senescence Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Hippo signaling pathway Focal adhesion Platelet activation Long-term potentiation Dopaminergic synapse Inflammatory mediator regulation of TRP channels Regulation of actin cytoskeleton Insulin signaling pathway Oxytocin signaling pathway Insulin resistance Amphetamine addiction Alcoholism Herpes simplex virus 1 infection Proteoglycans in cancer Diabetic cardiomyopathy Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation +25 more

Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors +2 more

cAMP signaling pathway Dopaminergic synapse Cocaine addiction Amphetamine addiction Alcoholism DARPP-32 events +3 more

mRNA surveillance pathway Sphingolipid signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Adrenergic signaling in cardiomyocytes Hippo signaling pathway Tight junction T cell receptor signaling pathway Dopaminergic synapse Chagas disease Hepatitis C Human papillomavirus infection +9 more

mRNA surveillance pathway Sphingolipid signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Adrenergic signaling in cardiomyocytes Hippo signaling pathway Tight junction T cell receptor signaling pathway Dopaminergic synapse Chagas disease Hepatitis C Human papillomavirus infection +9 more

mRNA surveillance pathway Sphingolipid signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Adrenergic signaling in cardiomyocytes T cell receptor signaling pathway Dopaminergic synapse Human papillomavirus infection +5 more

MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway Oocyte meiosis Cellular senescence Wnt signaling pathway Axon guidance VEGF signaling pathway Osteoclast differentiation C-type lectin receptor signaling pathway Natural killer cell mediated cytotoxicity Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway B cell receptor signaling pathway Long-term potentiation Glutamatergic synapse Dopaminergic synapse Oxytocin signaling pathway Glucagon signaling pathway Renin secretion Alzheimer disease Amyotrophic lateral sclerosis Prion disease Pathways of neurodegeneration - multiple diseases Amphetamine addiction Tuberculosis Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection PD-L1 expression and PD-1 checkpoint pathway in cancer Lipid and atherosclerosis Activation of BAD and translocation to mitochondria +31 more

FoxO signaling pathway AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Apelin signaling pathway Tight junction Circadian rhythm Thermogenesis Insulin signaling pathway Adipocytokine signaling pathway Oxytocin signaling pathway Glucagon signaling pathway Insulin resistance Non-alcoholic fatty liver disease Alcoholic liver disease Hypertrophic cardiomyopathy Macroautophagy AMPK inhibits chREBP transcriptional activation activity Carnitine metabolism Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation +19 more

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway HIF-1 signaling pathway Phosphatidylinositol signaling system Sphingolipid signaling pathway Phospholipase D signaling pathway mTOR signaling pathway PI3K-Akt signaling pathway Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Wnt signaling pathway Axon guidance VEGF signaling pathway Focal adhesion Gap junction Neutrophil extracellular trap formation Natural killer cell mediated cytotoxicity Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Circadian entrainment Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Long-term depression Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Melanogenesis Thyroid hormone synthesis Thyroid hormone signaling pathway Oxytocin signaling pathway Aldosterone synthesis and secretion Relaxin signaling pathway Parathyroid hormone synthesis, secretion and action GnRH secretion AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Aldosterone-regulated sodium reabsorption Endocrine and other factor-regulated calcium reabsorption Salivary secretion Gastric acid secretion Pancreatic secretion Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Amphetamine addiction Morphine addiction Vibrio cholerae infection African trypanosomiasis Amoebiasis Hepatitis B Human cytomegalovirus infection Influenza A Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Glioma Non-small cell lung cancer Hepatocellular carcinoma Choline metabolism in cancer Diabetic cardiomyopathy Lipid and atherosclerosis Calmodulin induced events Disinhibition of SNARE formation SHC1 events in ERBB2 signaling Signaling by SCF-KIT Regulation of KIT signaling EGFR Transactivation by Gastrin Syndecan interactions Acetylcholine regulates insulin secretion Trafficking of GluR2-containing AMPA receptors Depolymerisation of the Nuclear Lamina HuR (ELAVL1) binds and stabilizes mRNA WNT5A-dependent internalization of FZD4 VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Response to elevated platelet cytosolic Ca2+ RET signaling ROBO receptors bind AKAP5 +87 more

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Metabolic pathways Synthesis of glycosylphosphatidylinositol (GPI)

Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins Type I hemidesmosome assembly +1 more

Synthesis of 5-eicosatetraenoic acids

cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Estrogen signaling pathway Melanogenesis Adipocytokine signaling pathway Aldosterone synthesis and secretion Cortisol synthesis and secretion Cushing syndrome Opioid Signalling Androgen biosynthesis Glucocorticoid biosynthesis G-protein activation Peptide hormone biosynthesis Endogenous sterols Peptide ligand-binding receptors G alpha (s) signalling events G alpha (i) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Interleukin-4 and Interleukin-13 signaling ADORA2B mediated anti-inflammatory cytokines production +18 more

EGR2 and SOX10-mediated initiation of Schwann cell myelination

cAMP signaling pathway Dopaminergic synapse Cocaine addiction Amphetamine addiction Alcoholism DARPP-32 events +3 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Estrogen signaling pathway Melanogenesis Adipocytokine signaling pathway Aldosterone synthesis and secretion Cortisol synthesis and secretion Cushing syndrome Opioid Signalling Androgen biosynthesis Glucocorticoid biosynthesis G-protein activation Peptide hormone biosynthesis Endogenous sterols Peptide ligand-binding receptors G alpha (s) signalling events G alpha (i) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Interleukin-4 and Interleukin-13 signaling ADORA2B mediated anti-inflammatory cytokines production +18 more

EGR2 and SOX10-mediated initiation of Schwann cell myelination

cAMP signaling pathway Dopaminergic synapse Cocaine addiction Amphetamine addiction Alcoholism DARPP-32 events +3 more