Bipolar disorder

cGMP-PKG signaling pathway Sphingolipid signaling pathway Vascular smooth muscle contraction Apelin signaling pathway Tight junction Fc gamma R-mediated phagocytosis Inflammatory mediator regulation of TRP channels Aldosterone synthesis and secretion Type II diabetes mellitus Insulin resistance AGE-RAGE signaling pathway in diabetic complications Shigellosis MicroRNAs in cancer Effects of PIP2 hydrolysis SHC1 events in ERBB2 signaling DAG and IP3 signaling Role of phospholipids in phagocytosis +14 more

Rap1 signaling pathway Endocytosis Hippo signaling pathway Tight junction Platelet activation Insulin signaling pathway Human papillomavirus infection Pre-NOTCH Transcription and Translation p75NTR recruits signalling complexes Tight junction interactions +7 more

Rap1 signaling pathway Chemokine signaling pathway Sphingolipid signaling pathway Endocytosis Axon guidance Hippo signaling pathway Tight junction Platelet activation Insulin signaling pathway Relaxin signaling pathway Type II diabetes mellitus Insulin resistance AGE-RAGE signaling pathway in diabetic complications Human papillomavirus infection Diabetic cardiomyopathy Fluid shear stress and atherosclerosis TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Estrogen-stimulated signaling through PRKCZ +17 more

Rap1 signaling pathway Aldosterone synthesis and secretion Chemical carcinogenesis - reactive oxygen species Sphingolipid de novo biosynthesis +1 more

Arginine and proline metabolism Metabolic pathways Proline catabolism

Peptide ligand-binding receptors G alpha (q) signalling events

Spliceosome mRNA Splicing - Major Pathway

Sphingolipid metabolism Lysosome Platelet degranulation Glycosphingolipid metabolism Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation +4 more

Post-translational modification: synthesis of GPI-anchored proteins

Notch signaling pathway Neurotrophin signaling pathway Alzheimer disease Pathways of neurodegeneration - multiple diseases Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 +9 more

Proteasome Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Spinocerebellar ataxia Prion disease Pathways of neurodegeneration - multiple diseases Human papillomavirus infection Epstein-Barr virus infection Viral carcinogenesis Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL N-glycan trimming in the ER and Calnexin/Calreticulin cycle Hedgehog ligand biogenesis Hh mutants that don't undergo autocatalytic processing are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Interleukin-1 signaling Antigen processing: Ubiquitination & Proteasome degradation +60 more

Arachidonic acid metabolism Metabolic pathways Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Arachidonic acid metabolism Metabolic pathways Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Nicotinamide salvaging Eicosanoids Sterols are 12-hydroxylated by CYP8B1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) +6 more

Insulin resistance Diabetic cardiomyopathy

Cell adhesion molecules T cell receptor signaling pathway Fc gamma R-mediated phagocytosis Salmonella infection Primary immunodeficiency Phosphorylation of CD3 and TCR zeta chains Other semaphorin interactions Neutrophil degranulation +5 more

Cell adhesion molecules Adherens junction Insulin signaling pathway Insulin resistance Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules +3 more

Type I diabetes mellitus Neutrophil degranulation

Folate biosynthesis Metabolic pathways Biosynthesis of cofactors Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation +1 more

Pancreatic secretion Platelet degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs +1 more

Measles Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production +1 more

Ras signaling pathway Rap1 signaling pathway

Pathways in cancer Small cell lung cancer Non-small cell lung cancer Gastric cancer Nuclear Receptor transcription pathway Signaling by Retinoic Acid +3 more

Ras signaling pathway Regulation of RAS by GAPs

MAPK signaling pathway Ras signaling pathway Focal adhesion RAF/MAP kinase cascade +1 more

MAPK signaling pathway Ras signaling pathway Platelet activation T cell receptor signaling pathway Pathways in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Activation of RAS in B cells Integrin signaling Rap1 signalling RAF/MAP kinase cascade +7 more

Adherens junction

Pentose phosphate pathway Metabolic pathways Pentose phosphate pathway

Notch signaling pathway Th1 and Th2 cell differentiation Spinocerebellar ataxia Human papillomavirus infection Epstein-Barr virus infection Viral carcinogenesis +3 more

Ribosome biogenesis in eukaryotes Major pathway of rRNA processing in the nucleolus and cytosol

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Spinocerebellar ataxia Human papillomavirus infection Reelin signalling pathway +3 more

Renin-angiotensin system Renin secretion Diabetic cardiomyopathy Metabolism of Angiotensinogen to Angiotensins +1 more

TGF-beta signaling pathway Axon guidance

G alpha (q) signalling events G alpha (i) signalling events

G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Notch signaling pathway Th1 and Th2 cell differentiation Spinocerebellar ataxia Human papillomavirus infection Epstein-Barr virus infection Viral carcinogenesis +3 more

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Spinocerebellar ataxia Human papillomavirus infection Reelin signalling pathway +3 more

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Spinocerebellar ataxia Human papillomavirus infection Reelin signalling pathway +3 more