Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
acute myeloid leukemia	MONDO_0018874 MONDO_0044923	RAD51B	Unknown	22237025	Open Targets	Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) +4 more
		RANBP2	Unknown	20428197 35986270 21399634	Open Targets	Nucleocytoplasmic transport Viral life cycle - HIV-1 Amyotrophic lateral sclerosis +32 more
		RAP1B	Unknown	22237025	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +25 more
		RAP1GDS1	Unknown	34778799	Open Targets	—
		RARA	Unknown	24673420 23936694 1314166 7682097 23355940 23589792 25052141 15899384 15359634 8380300 26299742 18665825 17934255 17415815 12399960 1720570 21350831 29795382 26728337 12899711 20544846 12508246 27063598 17454588 23627671 26823883 24981688	Open Targets	Th17 cell differentiation Estrogen signaling pathway Pathways in cancer +6 more
		RB1	Unknown	37002311 27276561 23153540	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RET	Unknown	25962120 27460089	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		RGS7	Unknown	22237025 24056718	Open Targets	G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
		RHOA	Unknown	25962120	Open Targets	Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway +64 more
		RICTOR	Unknown	29795382	Open Targets	mTOR signaling pathway PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling +3 more
		RMI2	Unknown	15327527	Open Targets	Fanconi anemia pathway HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) +7 more
		RNF213	Unknown	29253671 26438511	Open Targets	Suppression of apoptosis Antigen processing: Ubiquitination & Proteasome degradation
		ROBO2	Unknown	29253671 22237025	Open Targets	Axon guidance Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO
		ROCK1	Unknown	26886259	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway +25 more
		ROS1	Unknown	30013198	Open Targets	—
		RPL22	Unknown	34778799	Open Targets	Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression +7 more
		RPL5	Unknown	25962120	Open Targets	Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression +7 more
		RUNX1T1	Unknown	7507193 27352183 18224418 11331327 11753612 26299742 7514242 26802623 16393685 18665825 27139612 9250799 17415815 18206543 21738341 20430445 12760263 16254134 24402164 8499624 8353289 9885986 9619731 20417866 7630188 7828132 11033733 17883173 22811791 22094584 15988144 7522291 15571802 16956837 8148423 8402610 1391946	Open Targets	Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia
		RXRA	Unknown	35986270	Open Targets	PPAR signaling pathway Efferocytosis PI3K-Akt signaling pathway +39 more
		SALL4	Unknown	29795382 22976956 34778799	Open Targets	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells Regulation of PTEN gene transcription
		SEPTIN5	Unknown	9600980	Open Targets	Parkinson disease Pathways of neurodegeneration - multiple diseases
		SEPTIN6	Unknown	11477664 16843108 18492691 14506700	Open Targets	Bacterial invasion of epithelial cells Shigellosis
		SEPTIN9	Unknown	21846973 12095151 20113838 18642054 10485469	Open Targets	Bacterial invasion of epithelial cells Shigellosis
		SET	Unknown	17296573 24449214 19166587	Open Targets	Condensation of Prophase Chromosomes HuR (ELAVL1) binds and stabilizes mRNA
		SETBP1	Unknown	23628959 25412851 37002311 34070172 26728869 31942545 23648668 25962120 37102976 29549983 31145495 23832012 22237025 27288520 35805006 23889083 32782768 33161783 27881874 34778799	Open Targets	—
		SETD1B	Unknown	29795382 30013198 26438511	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		SETD2	Unknown	27462774 27798625 26941285 25962120 27359055 38212634 26883104 34778799	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SFPQ	Unknown	22976956	Open Targets	PTK6 Regulates Proteins Involved in RNA Processing Suppression of apoptosis
		SH2B3	Unknown	27276561 30013198 34070172 24056718 26438511	Open Targets	Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
		SH3GL1	Unknown	9122235	Open Targets	Endocytosis EGFR downregulation Negative regulation of MET activity +2 more
		SHTN1	Unknown	22237025	Open Targets	—
		SKI	Unknown	34778799	Open Targets	TGF-beta signaling pathway Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity
		SLC45A3	Unknown	29253671	Open Targets	Transcriptional misregulation in cancer MicroRNAs in cancer Cellular hexose transport
		SMAD4	Unknown	11244507	Open Targets	FoxO signaling pathway Hormone signaling Cell cycle +30 more
		SMARCA4	Unknown	22237025 34778799	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +6 more
		SMARCB1	Unknown	31648334 12684622 27460089 38212634 34778799	Open Targets	ATP-dependent chromatin remodeling Viral life cycle - HIV-1 Thermogenesis +3 more
		SMC1A	Unknown	24056718 25381062 26438511 27288520 27798625 29253671 31648334 33711909 34070172 34778799 37002311 38212634	Open Targets	Cell cycle Oocyte meiosis Separation of Sister Chromatids +5 more
		SMO	Unknown	27460089 34778799	Open Targets	Hedgehog signaling pathway Axon guidance Pathways in cancer +6 more
		SNX29	Unknown	34778799	Open Targets	—
		SOCS1	Unknown	15327527	Open Targets	Ubiquitin mediated proteolysis Osteoclast differentiation JAK-STAT signaling pathway +13 more
		SOS1	Unknown	30013198 38212634 34778799	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +97 more
		SOX2	Unknown	34778799	Open Targets	Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation +4 more
		SPEN	Unknown	29253671 35986270	Open Targets	Notch signaling pathway
		SPOP	Unknown	34778799	Open Targets	Hedgehog signaling pathway Hedgehog 'on' state
		SS18	Unknown	29253671	Open Targets	ATP-dependent chromatin remodeling Transcriptional misregulation in cancer
		SS18L1	Unknown	26883104	Open Targets	ATP-dependent chromatin remodeling Transcriptional misregulation in cancer
		STAG1	Unknown	29795382 22237025 26438511	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		STAG2	Unknown	22649106 23832012 23955599 24056718 24067491 24335498 26438511 26728869 27276561 27288520 27435003 27470916 27881874 28063196 30013198 31942545 33618432 34070172 34301788 34778799 35805006 37002311 37102976 38212634	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		STAT3	Unknown	37002311	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway HIF-1 signaling pathway +53 more
		STAT5B	Unknown	34301788 19624718 34778799	Open Targets	ErbB signaling pathway Chemokine signaling pathway Hormone signaling +28 more

Acute myeloid leukemia

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