Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
acute myeloid leukemia	MONDO_0018874 MONDO_0044923	NTRK3	Unknown	11568911 22237025 32315394 34778799 37002311 9949179	Open Targets	Calcium signaling pathway Neurotrophin signaling pathway Central carbon metabolism in cancer +4 more
		NUMA1	Unknown	22237025	Open Targets	Recruitment of NuMA to mitotic centrosomes Mitotic Prophase
		NUP214	Unknown	22897847 17296573 34778799 24449214 19166587	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis ISG15 antiviral mechanism +26 more
		NUP98	Unknown	34778799 27114462 23153540	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Influenza A +33 more
		PABPC1	Unknown	34778799	Open Targets	mRNA surveillance pathway RNA degradation L13a-mediated translational silencing of Ceruloplasmin expression +5 more
		PAFAH1B2	Unknown	34778799	Open Targets	Ether lipid metabolism Metabolic pathways Neutrophil degranulation +1 more
		PAX3	Unknown	34778799	Open Targets	Transcriptional misregulation in cancer HATs acetylate histones
		PAX5	Unknown	25962120 22237025 26883104 27470916	Open Targets	Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in BCR signaling
		PAX7	Unknown	34778799	Open Targets	Transcriptional misregulation in cancer
		PBRM1	Unknown	21399634	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		PBX1	Unknown	24056718 7734349	Open Targets	Efferocytosis Cortisol synthesis and secretion Cushing syndrome +3 more
		PCM1	Unknown	16034466 18594780 22237025	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +4 more
		PDE4DIP	Unknown	31648334	Open Targets	—
		PDGFRA	Unknown	29795382 37002311 12660384 15674355	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
		PDGFRB	Unknown	28485070 21350831 23153540 21233837	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +22 more
		PHF6	Unknown	21030981 21736506 22237025 24036946 26728869 26980726 27276561 27288520 27881874 27885656 27997762 31713024 33054115 33618432 34070172 34301788 34778799 35078972 35805006 37002311 37102976 38019014 38212634	Open Targets	ATP-dependent chromatin remodeling
		PHOX2B	Unknown	26883104	Open Targets	—
		PICALM	Unknown	12461747	Open Targets	Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
		PIK3CA	Unknown	38212634	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3R1	Unknown	25962120 34778799	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		PLAG1	Unknown	34778799	Open Targets	—
		PLCG1	Unknown	29253671	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +70 more
		PLEC	Unknown	34778799	Open Targets	Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins +1 more
		PML	Unknown	24673420 23936694 1314166 7682097 23355940 23589792 25052141 15899384 15359634 8380300 26299742 18665825 17934255 17415815 12399960 1720570 21350831 26728337 12899711 20544846 12508246 27063598 17454588 23627671 26823883 24981688	Open Targets	Ubiquitin mediated proteolysis Endocytosis Influenza A +12 more
		PMS2	Unknown	37002311 37305720	Open Targets	Mismatch repair Fanconi anemia pathway Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) +3 more
		POLD1	Unknown	26438511	Open Targets	DNA replication Base excision repair Nucleotide excision repair +19 more
		POLE	Unknown	30013198 24056718 27063598 22976956	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		POLQ	Unknown	25962120 34778799	Open Targets	HDR through MMEJ (alt-NHEJ)
		POLR2A	Unknown	22237025	Open Targets	RNA polymerase Nucleotide excision repair Huntington disease +25 more
		PPFIBP1	Unknown	34778799	Open Targets	Receptor-type tyrosine-protein phosphatases
		PRDM1	Unknown	34778799	Open Targets	Regulation of TP53 Expression
		PRDM16	Unknown	22237025	Open Targets	Lysine degradation Metabolic pathways Thermogenesis +1 more
		PRDM2	Unknown	22976956	Open Targets	Lysine degradation Metabolic pathways
		PREX2	Unknown	22237025 26883104	Open Targets	Regulation of PTEN stability and activity
		PRKACA	Unknown	25962120	Open Targets	Endocrine resistance MAPK signaling pathway Ras signaling pathway +95 more
		PRKAR1A	Unknown	34778799	Open Targets	Insulin signaling pathway PKA activation PKA activation in glucagon signalling +7 more
		PRKD1	Unknown	26941285 22237025	Open Targets	Rap1 signaling pathway Aldosterone synthesis and secretion Chemical carcinogenesis - reactive oxygen species +1 more
		PRPF40B	Unknown	27276561 34070172	Open Targets	Spliceosome
		PRRX1	Unknown	22237025	Open Targets	—
		PSIP1	Unknown	34778799	Open Targets	Viral life cycle - HIV-1 Integration of provirus 2-LTR circle formation +4 more
		PTCH1	Unknown	34778799	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTEN	Unknown	27276561 22237025 27288520 10966170 24831771	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPN11	Unknown	12717436 14644997 14982869 15009076 15385933 15604238 15667533 15749679 15755284 15834506 15842656 15951301 16115145 16358218 16424869 16518851 17972951 19773259 20693432 22658276 23702683 24036946 24056718 24771269 25022553 25331116 25381062 25381129 25962120 26438511 26728869 26941285 26980726 27276561 27288520 27359055 27435003 27460089 27462774 27798625 27881874 29253671 30396184 31145495 31184605 31232041 33020650 33574648 33618432 33711909 34301788 34778799 35078972 35805006 36444394 37002311 37102976 38025540 38212634 38986489	Open Targets	Ras signaling pathway Phospholipase D signaling pathway Efferocytosis +56 more
		PTPN13	Unknown	22237025 27997762 34778799	Open Targets	Apoptosis Synthesis of PIPs at the plasma membrane Interleukin-37 signaling
		PTPRB	Unknown	27798625	Open Targets	Adherens junction Neutrophil degranulation
		PTPRD	Unknown	22237025	Open Targets	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		PTPRK	Unknown	22237025	Open Targets	EGFR downregulation
		PTPRT	Unknown	24493670 29253671 26941285 26886259 29795382 22237025 27288520 26438511 27063598	Open Targets	—
		PWWP2A	Unknown	26941285	Open Targets	—
		RAD21	Unknown	22976956 23955599 24056718 24335498 26438511 26728869 26980726 27276561 27288520 27470916 27798625 27881874 28063196 33618432 34070172 34301788 34778799 35805006 37002311 37102976 37853686 38212634	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more

Acute myeloid leukemia

Bookmark This Disease