Subtype of: Acute myeloid leukemia

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
acute myeloid leukemia, t(3;5)(q25;q34)	MONDO_0100409	ARHGAP35	Unknown	29146900	Open Targets	Focal adhesion Platelet activation Leukocyte transendothelial migration +4 more
		ASXL1	Unknown	19388938 19865112 25412851 24030381 24127063 22431577 31942545 24531734 25331116 24218139 32604058 27359055 23889083 33161783 23996483 34492730 22912701 35805006 28063196	Open Targets	Polycomb repressive complex UCH proteinases
		ATM	Unknown	21909114	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		BCOR	Unknown	33832922 24030381 29780592 29146900 38212634 34492730 35805006 27884971	Open Targets	Polycomb repressive complex
		BCORL1	Unknown	24047651 21989985 29780592 34301788 38212634 35805006	Open Targets	Polycomb repressive complex
		BRAF	Unknown	24030381	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		CALR	Unknown	24531734 24850292	Open Targets	Protein processing in endoplasmic reticulum Phagosome Efferocytosis +14 more
		CARD11	Unknown	21176849	Open Targets	NF-kappa B signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway +4 more
		CBL	Unknown	29682367 20674974 24147083 22131879 35805006 19074904 20678218	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +22 more
		CDH1	Unknown	24030381	Open Targets	Rap1 signaling pathway Apelin signaling pathway Hippo signaling pathway +15 more
		CDKN1B	Unknown	25331116	Open Targets	Endocrine resistance ErbB signaling pathway HIF-1 signaling pathway +28 more
		CDKN2A	Unknown	29780592	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CEBPA	Unknown	22389883 24030381 31942545 27359055 12592334 20884804 25014773 23996483 35805006 30355724	Open Targets	Non-alcoholic fatty liver disease Pathways in cancer Transcriptional misregulation in cancer +3 more
		CSF1R	Unknown	2406720 24030381	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +10 more
		CSF3R	Unknown	24523240 12588357 7542747 25404019 15284863 19833857	Open Targets	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway +3 more
		CTCF	Unknown	29146900	Open Targets	—
		CUX1	Unknown	35805006	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Intra-Golgi traffic
		DNMT3A	Unknown	33832922 24030381 21989985 27458708 31149783 20400977 22642896 32604058 21993668 27359055 29780592 34617422 23031157 23996483 27029036 35805006 27884971	Open Targets	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		EML4	Unknown	21909114	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer +1 more
		EP300	Unknown	24523240 24030381 20980053	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +66 more
		ETV6	Unknown	29146900 24030381 35805006 21600651 21909114	Open Targets	Transcriptional misregulation in cancer Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
		EZH2	Unknown	24030381 24127063 21909114 24218139 27458708 35805006	Open Targets	Lysine degradation Metabolic pathways Polycomb repressive complex +7 more
		FBXO11	Unknown	21909114	Open Targets	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		FLT3	Unknown	20040759 24030381 22431577 17079011 23969938 19626050 20670134 34492730 19074904 12759922 20066533 23300180 21233837 22658276 22642896 34617422 20520634 22132874 34301788 21135859 22038701 18068628 23417030 24522528 33832922 18664261 18503825 21909114 15543237 15710585 24850292 21989985 29146900 24372512 23996483 35805006 20979630	Open Targets	MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway +8 more
		GATA1	Unknown	20418238	Open Targets	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		GATA2	Unknown	33832922 24030381 29780592 32604058 29146900 35805006	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		HRAS	Unknown	35805006	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		IDH1	Unknown	33832922 20376084 24030381 22431577 21989985 31942545 27458708 21909114 24218139 34617422 27359055 20946881 20494930 23889083 23996483 34492730 22912701 35805006 30355724	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more
		IDH2	Unknown	24030381 22431577 27458708 24218139 32604058 34492730 22912701 20678218 38009542 31086779 34617422 20494930 20376084 21250968 27359055 20861910 21625234 21989985 31942545 29146900 20946881 23996483 35805006 30355724	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		IKZF1	Unknown	35805006	Open Targets	—
		JAK1	Unknown	30355724	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		JAK2	Unknown	25412851 31086779 24030381 19773259 18030353 31942545 19562620 16081687 27359055 16434499 19744708 22131879 35805006 16741247 34492730 17443220 17344916 19074904 16990762	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		JAK3	Unknown	20400977 30355724	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		KDM5A	Unknown	24030381	Open Targets	HDMs demethylate histones
		KDM6A	Unknown	24030381	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KIT	Unknown	27359055 34492730 24030381 35805006 16533529	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KMT2A	Unknown	12124344 24030381 20980053 20520634 15710585 24147083 10803509	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	34301788	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	24030381	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KNSTRN	Unknown	29146900	Open Targets	—
		KRAS	Unknown	33832922 31942545 25331116 21909114 24105326 23996483 34492730 35805006	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LOC100506403	Unknown	24523240 24030381 24531734 32604058 34492730 11049997 20678218 23300180 12874780 20520634 38212634 33161783 24522528 19773259 12393679 21909114 27359055 17910630 27884971 23996483 19414191 21989985 31942545 25331116 14615365 27458708 35805006	Open Targets	—
		MED12	Unknown	21909114	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MET	Unknown	24030381	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MN1	Unknown	24030381 21600651	Open Targets	—
		MPL	Unknown	29146900 19194467	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling JAK-STAT signaling pathway
		MUC6	Unknown	29146900	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MYD88	Unknown	27884971	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Toll-like receptor signaling pathway +39 more
		NF1	Unknown	22015770 29146900 34492730 24030381	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NPM1	Unknown	23417030 24522528 24030381 18664261 21233837 21989985 19100523 31149783 22642896 34617422 27359055 29146900 24764728 35805006 23996483 22338050 17504301 38009542	Open Targets	Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere +2 more

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Acute myeloid leukemia, t(3;5)(q25;q34)

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