Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
acute myeloid leukemia	MONDO_0018874	STK11	Unknown	29795382	Open Targets	FoxO signaling pathway Hormone signaling Autophagy - animal +9 more
		STRN	Unknown	34778799	Open Targets	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling +2 more
		SUFU	Unknown	24056718	Open Targets	Hedgehog signaling pathway Pathways in cancer Basal cell carcinoma +4 more
		SUZ12	Unknown	37002311 38019014 22237025 24056718 34778799	Open Targets	Polycomb repressive complex PRC2 methylates histones and DNA Oxidative Stress Induced Senescence +5 more
		TCF3	Unknown	29253671 7734349 34778799	Open Targets	Signaling pathways regulating pluripotency of stem cells Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer +2 more
		TENT5C	Unknown	31648334 22237025	Open Targets	—
		TET1	Unknown	22237025 26438511 22976956	Open Targets	—
		TET2	Unknown	19295549 19474426 20489055 20678218 20693430 21042320 21343549 21637286 21828143 22017486 22071137 22116554 22234698 22390313 22431577 22520341 22976956 23135354 23613835 23702683 23753029 23832012 24036946 24045501 24859829 24898826 24931631 24994606 25022553 25241285 25381062 25381129 25412851 25652455 26414667 26438511 26728869 26941285 26980726 27029036 27063598 27276561 27288520 27359055 27435003 27458708 27798625 27881874 27908881 27997762 29417354 29795382 30013198 30355724 31145495 31184605 31187595 31232041 31648334 31827512 31942545 33054115 33099879 33161783 33618432 33711909 34070172 34132463 34492730 34778799 35805006 36672788 37002311 37102976 37853686 38204493 38212634	Open Targets	—
		TFE3	Unknown	29795382 31648334	Open Targets	Mitophagy - animal Transcriptional misregulation in cancer Renal cell carcinoma
		TFG	Unknown	34778799	Open Targets	Pathways in cancer Thyroid cancer COPII-mediated vesicle transport
		TNC	Unknown	25962120 24056718 34778799	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +6 more
		TP63	Unknown	34778799	Open Targets	MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes +5 more
		TPR	Unknown	34778799	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Pathways in cancer +27 more
		TRAF7	Unknown	38212634	Open Targets	Antigen processing: Ubiquitination & Proteasome degradation
		TRIM24	Unknown	22976956 34778799	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF fusions
		TRIM33	Unknown	34778799	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity
		TRRAP	Unknown	22976956	Open Targets	ATP-dependent chromatin remodeling Human T-cell leukemia virus 1 infection Formation of the beta-catenin:TCF transactivating complex +1 more
		TSC2	Unknown	27798625	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more
		TSHR	Unknown	22237025	Open Targets	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +6 more
		USP6	Unknown	26886259	Open Targets	—
		USP9X	Unknown	27798625 26941285 24036946 30013198	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes +2 more
		VAV1	Unknown	34778799	Open Targets	Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway +30 more
		VHL	Unknown	34070172	Open Targets	HIF-1 signaling pathway Ubiquitin mediated proteolysis Pathways in cancer +5 more
		VTI1A	Unknown	22237025 24056718	Open Targets	SNARE interactions in vesicular transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
		WIF1	Unknown	34778799	Open Targets	Wnt signaling pathway
		WNK2	Unknown	29253671 24036946 22237025 34778799	Open Targets	Parathyroid hormone synthesis, secretion and action Stimuli-sensing channels
		WRN	Unknown	37002311	Open Targets	Processive synthesis on the C-strand of the telomere Removal of the Flap Intermediate from the C-strand SUMOylation of DNA damage response and repair proteins +9 more
		WT1	Unknown	10338002 16230371 18559874 19171881 19322206 19536888 20053758 20368469 20442368 20678218 20861915 21399634 21504297 21606962 21798259 21836609 21967978 22234698 22237025 22506617 22786876 22814295 22976956 23702683 23753029 23816818 24033149 24036946 24056718 24523240 24898826 25022553 25381062 25381129 26438511 26728869 26941285 26980726 27063598 27276561 27288520 27359055 27435003 27458708 27462774 27470916 27798625 27881874 27908881 29253671 29795382 30013198 31145495 31515708 31648334 31827512 33020650 33054115 33574648 33618432 33711909 34070172 34301788 34778799 34992253 35805006 35986270 36672788 37002311 37102976 37305720 37794441 37853686 38212634 7833922 8630376 9531607	Open Targets	Transcriptional misregulation in cancer
		XPO1	Unknown	37002311 30013198 34778799	Open Targets	Ribosome biogenesis in eukaryotes Nucleocytoplasmic transport Viral life cycle - HIV-1 +15 more
		YAP1	Unknown	34778799	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Nuclear signaling by ERBB4 +5 more
		ZEB1	Unknown	24056718	Open Targets	Transcriptional misregulation in cancer MicroRNAs in cancer Prostate cancer +1 more
		ZFHX3	Unknown	22237025 26438511 24056718	Open Targets	Signaling pathways regulating pluripotency of stem cells RUNX3 regulates CDKN1A transcription
		ZMYM2	Unknown	22237025 34778799	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease
		ZMYM3	Unknown	34778799	Open Targets	—
		ZNF384	Unknown	26941285	Open Targets	—
		ZNRF3	Unknown	22237025	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination
		ZRSR2	Unknown	24923295 24931631 25381062 27276561 27288520 27435003 27881874 31145495 31184605 33711909 34070172 35805006 38212634	Open Targets	mRNA Splicing - Minor Pathway
Aml	MONDO_0018874	BLM	Unknown	28297620	Open Targets	Homologous recombination Fanconi anemia pathway Processive synthesis on the C-strand of the telomere +10 more
		CTC1	Unknown	28297620 27881370	Open Targets	Telomere C-strand synthesis initiation
		ERCC4	Unknown	28297620	Open Targets	Nucleotide excision repair Fanconi anemia pathway HDR through Single Strand Annealing (SSA) +4 more
		FANCA	Unknown	28297620	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCB	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCD2	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
		FANCE	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCF	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCG	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCI	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
		FANCL	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Ubiquitin mediated proteolysis Fanconi Anemia Pathway
		FANCM	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		MAD2L2	Unknown	28297620	Open Targets	Cell cycle Oocyte meiosis Progesterone-mediated oocyte maturation +4 more
AML, Acute myeloid leukaemia (AML)	MONDO_0018874	FANCD2	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes

Acute myeloid leukemia

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