Subtype of: Acute myeloid leukemia

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
therapy related acute myeloid leukemia and myelodysplastic syndrome	MONDO_0019457	ALK	Unknown	24307515	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		ARID1A	Unknown	25516983	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ASXL1	Unknown	19388938 19865112 23246161 24127063 22431577 24697267 25516983 29148089 35122691 22489043 30355724 21921040 20068184 23889083 21828135 22912701 19609284 21712540 23996481 24011025	Open Targets	Polycomb repressive complex UCH proteinases
		BCOR	Unknown	29148089	Open Targets	Polycomb repressive complex
		BCORL1	Unknown	21989985 29148089	Open Targets	Polycomb repressive complex
		CALR	Unknown	25249012 24325359 24749731 29148089	Open Targets	Protein processing in endoplasmic reticulum Phagosome Efferocytosis +14 more
		CBL	Unknown	22658276 24147083 19074904 29148089 20008300	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +22 more
		CEBPA	Unknown	24522528 30355724 29148089	Open Targets	Non-alcoholic fatty liver disease Pathways in cancer Transcriptional misregulation in cancer +3 more
		CSF1R	Unknown	18971950	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +10 more
		CSF3R	Unknown	27449473 29148089	Open Targets	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway +3 more
		CUX1	Unknown	21674579 29148089	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Intra-Golgi traffic
		DNMT3A	Unknown	22431577 21989985 22489043 20400977 22642896 25809997 21993668 29148089 21828135 23996481	Open Targets	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		ELL	Unknown	18617060	Open Targets	Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events +4 more
		ETV6	Unknown	17122866 21233837	Open Targets	Transcriptional misregulation in cancer Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
		EWSR1	Unknown	27594918	Open Targets	Transcriptional misregulation in cancer
		EZH2	Unknown	33054115 24127063 24697267 25516983 30355724 29148089 21921040 20601953 23996481	Open Targets	Lysine degradation Metabolic pathways Polycomb repressive complex +7 more
		FLT3	Unknown	23417030 19865112 21531982 22431577 20008300 21233837 33099879 19626050 17363731 29148089 20520641 19074904 23246161	Open Targets	MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway +8 more
		GATA2	Unknown	29148089	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		IDH1	Unknown	20107228 21531982 22431577 22658276 20508616 25809997 21288114 20410924 29148089 21828135 25516983 30355724	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more
		IDH2	Unknown	24522528 20107228 21625234 21531982 35122691 20508616 24981691 22489043 21250968 25516983 25809997 21288114 20724988 20410924 29148089 22912701 33099879 20678218 30355724	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		IKZF1	Unknown	29148089	Open Targets	—
		JAK2	Unknown	19262601 20508609 22431577 23210734 19691103 18318760 16037387 19194467 30355724 21376394 21674579 22422826 19074904 18078991 21531982 18030353 21233837 20508616 17363731 20724988 21921040 17460705 24404189 23996481 19564637 19773259 20008300 20425802 22489043 18455791 21288114 20068184 19710701 21421540 27594918 16557239 17625612 16956348 17509995 17643100 17111143 20410924 29148089 21689158 25516983	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		KDM6A	Unknown	21828135	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KMT2A	Unknown	15710585 30431598 29148089 18617060	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2D	Unknown	25516983	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	22431577 24697267 35122691 29148089 21828135 25516983	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LOC100506403	Unknown	21531982 24127063 21933280 20008300 22431577 29148089 25516983 20678218 30355724	Open Targets	—
		MPL	Unknown	19029146 22431577 20508609 20508616 22489043 21288114 34288445 20823136 20410924 25516983 29148089	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling JAK-STAT signaling pathway
		MYB	Unknown	27594918	Open Targets	PI3K-Akt signaling pathway RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression
		NF1	Unknown	22015770 29148089	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NOTCH1	Unknown	29148089	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NPM1	Unknown	23417030 24522528 21531982 21233837 21707751 25809997 29148089 19100523 21689158 33099879 22978565	Open Targets	Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere +2 more
		NRAS	Unknown	19773259 24127063 20008300 22431577 24697267 21127188 25809997 29148089 21828135 25516983 19074904	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		PAX5	Unknown	29148089	Open Targets	Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in BCR signaling
		PDGFRB	Unknown	17122866 21233837	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +22 more
		PHF6	Unknown	22431577 29148089	Open Targets	ATP-dependent chromatin remodeling
		PTCH1	Unknown	25516983	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTEN	Unknown	22431577	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPN11	Unknown	33054115 25516983 19773259 18925961 29148089	Open Targets	Ras signaling pathway Phospholipase D signaling pathway Efferocytosis +56 more
		RAD21	Unknown	29148089	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		RANBP2	Unknown	24307515	Open Targets	Nucleocytoplasmic transport Viral life cycle - HIV-1 Amyotrophic lateral sclerosis +32 more
		RB1	Unknown	29148089	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		SETBP1	Unknown	23889083 25516983 24127063 23443343 29148089	Open Targets	—
		SF3B1	Unknown	22489043 25516983 24127063 29148089 23996481	Open Targets	Spliceosome B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway +1 more
		SH2B3	Unknown	20724988 29148089	Open Targets	Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
		SRSF2	Unknown	33054115 22431577 24981691 29148089 27594918 23996481	Open Targets	Spliceosome Herpes simplex virus 1 infection Transport of Mature mRNA derived from an Intron-Containing Transcript +4 more
		STAG2	Unknown	29148089	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		SUZ12	Unknown	22489043	Open Targets	Polycomb repressive complex PRC2 methylates histones and DNA Oxidative Stress Induced Senescence +5 more
		TET2	Unknown	22431577 19262601 24371780 22912701 20678218 19797729 24981691 19295549 23996481 19564637 27449473 24697267 20008300 22489043 20068184 19710701 20823136 30431598 27594918 33054115 21625234 19372255 23889083 29148089 30355724	Open Targets	—
		TP53	Unknown	21531982 22431577 23210734 8652390 21288114 20823136 29148089 25516983 23996481	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more

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Therapy related acute myeloid leukemia and myelodysplastic syndrome

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