Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
acute myeloid leukemia	MONDO_0018874	MUC16	Unknown	27798625 29795382 22237025 30013198 26438511 34778799	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC4	Unknown	22237025 34778799	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC6	Unknown	27798625	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUTYH	Unknown	34778799	Open Targets	Base excision repair Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine +2 more
		MYB	Unknown	29795382	Open Targets	PI3K-Akt signaling pathway RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression
		MYH11	Unknown	26941285 25962120 30013198	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +6 more
		NBEA	Unknown	26941285	Open Targets	—
		NBN	Unknown	25962120	Open Targets	Homologous recombination Cellular senescence DNA Damage/Telomere Stress Induced Senescence +13 more
		NCOA2	Unknown	22237025	Open Targets	Estrogen signaling pathway Thyroid hormone signaling pathway RORA activates gene expression +14 more
		NCOR1	Unknown	27798625 25381062 38212634	Open Targets	Endocrine resistance TGF-beta signaling pathway Thyroid hormone signaling pathway +16 more
		NCOR2	Unknown	22976956	Open Targets	Notch signaling pathway Epstein-Barr virus infection PPARA activates gene expression +11 more
		NF2	Unknown	22081132	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Tight junction +2 more
		NFATC2	Unknown	34778799	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway Efferocytosis +24 more
		NFE2L2	Unknown	22237025 34778799	Open Targets	Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer +4 more
		NFKB2	Unknown	26883104	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Osteoclast differentiation +19 more
		NIN	Unknown	29795382	Open Targets	—
		NKX2-1	Unknown	35986270	Open Targets	—
		NOTCH1	Unknown	17008890 17107915 17671232 18281529 22976956 25962120 26438511 27288520 31184605 33711909 34301788 34778799 35805006 37002311 37853686 38212634	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	25564152 26941285 37305720	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NR2F2	Unknown	34778799	Open Targets	—
		NRG1	Unknown	26941285	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis +18 more
		NSD2	Unknown	29795382 22237025	Open Targets	Lysine degradation Metabolic pathways Transcriptional misregulation in cancer +5 more
		NT5C2	Unknown	29795382 27288520	Open Targets	Purine metabolism Pyrimidine metabolism Nicotinate and nicotinamide metabolism +4 more
		NTRK2	Unknown	22237025 32315394 34778799	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +6 more
		NTRK3	Unknown	11568911 22237025 32315394 34778799 37002311 9949179	Open Targets	Calcium signaling pathway Neurotrophin signaling pathway Central carbon metabolism in cancer +4 more
		NUMA1	Unknown	22237025	Open Targets	Recruitment of NuMA to mitotic centrosomes Mitotic Prophase
		NUP214	Unknown	22897847 17296573 34778799 24449214 19166587	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis ISG15 antiviral mechanism +26 more
		NUP98	Unknown	34778799 27114462 23153540	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Influenza A +33 more
		PABPC1	Unknown	34778799	Open Targets	mRNA surveillance pathway RNA degradation L13a-mediated translational silencing of Ceruloplasmin expression +5 more
		PAFAH1B2	Unknown	34778799	Open Targets	Ether lipid metabolism Metabolic pathways Neutrophil degranulation +1 more
		PAX3	Unknown	34778799	Open Targets	Transcriptional misregulation in cancer HATs acetylate histones
		PAX5	Unknown	25962120 22237025 26883104 27470916	Open Targets	Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in BCR signaling
		PAX7	Unknown	34778799	Open Targets	Transcriptional misregulation in cancer
		PBRM1	Unknown	21399634	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		PBX1	Unknown	24056718 7734349	Open Targets	Efferocytosis Cortisol synthesis and secretion Cushing syndrome +3 more
		PCM1	Unknown	16034466 18594780 22237025	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +4 more
		PDE4DIP	Unknown	31648334	Open Targets	—
		PDGFRA	Unknown	29795382 37002311 12660384 15674355	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
		PDGFRB	Unknown	28485070 21350831 23153540 21233837	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +22 more
		PHF6	Unknown	21030981 21736506 22237025 24036946 26728869 26980726 27276561 27288520 27881874 27885656 27997762 31713024 33054115 33618432 34070172 34301788 34778799 35078972 35805006 37002311 37102976 38019014 38212634	Open Targets	ATP-dependent chromatin remodeling
		PHOX2B	Unknown	26883104	Open Targets	—
		PICALM	Unknown	12461747	Open Targets	Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
		PIK3CA	Unknown	38212634	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3R1	Unknown	25962120 34778799	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		PLAG1	Unknown	34778799	Open Targets	—
		PLCG1	Unknown	29253671	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +70 more
		PLEC	Unknown	34778799	Open Targets	Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins +1 more
		PML	Unknown	24673420 23936694 1314166 7682097 23355940 23589792 25052141 15899384 15359634 8380300 26299742 18665825 17934255 17415815 12399960 1720570 21350831 26728337 12899711 20544846 12508246 27063598 17454588 23627671 26823883 24981688	Open Targets	Ubiquitin mediated proteolysis Endocytosis Influenza A +12 more
		PMS2	Unknown	37002311 37305720	Open Targets	Mismatch repair Fanconi anemia pathway Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) +3 more
		POLD1	Unknown	26438511	Open Targets	DNA replication Base excision repair Nucleotide excision repair +19 more

Acute myeloid leukemia

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