Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
acute myeloid leukemia	MONDO_0018874	WRN	Unknown	37002311	Open Targets	Processive synthesis on the C-strand of the telomere Removal of the Flap Intermediate from the C-strand SUMOylation of DNA damage response and repair proteins +9 more
		WT1	Unknown	10338002 16230371 18559874 19171881 19322206 19536888 20053758 20368469 20442368 20678218 20861915 21399634 21504297 21606962 21798259 21836609 21967978 22234698 22237025 22506617 22786876 22814295 22976956 23702683 23753029 23816818 24033149 24036946 24056718 24523240 24898826 25022553 25381062 25381129 26438511 26728869 26941285 26980726 27063598 27276561 27288520 27359055 27435003 27458708 27462774 27470916 27798625 27881874 27908881 29253671 29795382 30013198 31145495 31515708 31648334 31827512 33020650 33054115 33574648 33618432 33711909 34070172 34301788 34778799 34992253 35805006 35986270 36672788 37002311 37102976 37305720 37794441 37853686 38212634 7833922 8630376 9531607	Open Targets	Transcriptional misregulation in cancer
		XPO1	Unknown	37002311 30013198 34778799	Open Targets	Ribosome biogenesis in eukaryotes Nucleocytoplasmic transport Viral life cycle - HIV-1 +15 more
		YAP1	Unknown	34778799	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Nuclear signaling by ERBB4 +5 more
		ZEB1	Unknown	24056718	Open Targets	Transcriptional misregulation in cancer MicroRNAs in cancer Prostate cancer +1 more
		ZFHX3	Unknown	22237025 26438511 24056718	Open Targets	Signaling pathways regulating pluripotency of stem cells RUNX3 regulates CDKN1A transcription
		ZMYM2	Unknown	22237025 34778799	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease
		ZMYM3	Unknown	34778799	Open Targets	—
		ZNF384	Unknown	26941285	Open Targets	—
		ZNRF3	Unknown	22237025	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination
		ZRSR2	Unknown	24923295 24931631 25381062 27276561 27288520 27435003 27881874 31145495 31184605 33711909 34070172 35805006 38212634	Open Targets	mRNA Splicing - Minor Pathway
Aml	MONDO_0018874	BLM	Unknown	28297620	Open Targets	Homologous recombination Fanconi anemia pathway Processive synthesis on the C-strand of the telomere +10 more
		CEBPA	Unknown	28297620 27881370	Open Targets	Non-alcoholic fatty liver disease Pathways in cancer Transcriptional misregulation in cancer +3 more
		CTC1	Unknown	28297620 27881370	Open Targets	Telomere C-strand synthesis initiation
		ERCC4	Unknown	28297620	Open Targets	Nucleotide excision repair Fanconi anemia pathway HDR through Single Strand Annealing (SSA) +4 more
		FANCA	Unknown	28297620	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCB	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCD2	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
		FANCE	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCF	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCG	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCI	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
		FANCL	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Ubiquitin mediated proteolysis Fanconi Anemia Pathway
		FANCM	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		MAD2L2	Unknown	28297620	Open Targets	Cell cycle Oocyte meiosis Progesterone-mediated oocyte maturation +4 more
		PALB2	Unknown	28297620 27881370	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +3 more
		RAD51C	Unknown	28297620 27881370	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +5 more
		SBDS	Unknown	28297620	Open Targets	Ribosome biogenesis in eukaryotes
		SLX4	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
		UBE2T	Unknown	28297620	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway Synthesis of active ubiquitin: roles of E1 and E2 enzymes
		XRCC2	Unknown	28297620	Open Targets	Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) +3 more
AML, Acute myeloid leukaemia (AML)	MONDO_0018874	FANCD2	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes

Acute myeloid leukemia

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