Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
acute myeloid leukemia	MONDO_0018874 MONDO_0044923	SETD2	Unknown	27462774 27798625 26941285 25962120 27359055 38212634 26883104 34778799	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SFPQ	Unknown	22976956	Open Targets	PTK6 Regulates Proteins Involved in RNA Processing Suppression of apoptosis
		SH2B3	Unknown	27276561 30013198 34070172 24056718 26438511	Open Targets	Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
		SH3GL1	Unknown	9122235	Open Targets	Endocytosis EGFR downregulation Negative regulation of MET activity +2 more
		SHTN1	Unknown	22237025	Open Targets	—
		SKI	Unknown	34778799	Open Targets	TGF-beta signaling pathway Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity
		SLC45A3	Unknown	29253671	Open Targets	Transcriptional misregulation in cancer MicroRNAs in cancer Cellular hexose transport
		SMAD4	Unknown	11244507	Open Targets	FoxO signaling pathway Hormone signaling Cell cycle +30 more
		SMARCA4	Unknown	22237025 34778799	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +6 more
		SMARCB1	Unknown	31648334 12684622 27460089 38212634 34778799	Open Targets	ATP-dependent chromatin remodeling Viral life cycle - HIV-1 Thermogenesis +3 more
		SMC1A	Unknown	24056718 25381062 26438511 27288520 27798625 29253671 31648334 33711909 34070172 34778799 37002311 38212634	Open Targets	Cell cycle Oocyte meiosis Separation of Sister Chromatids +5 more
		SMO	Unknown	27460089 34778799	Open Targets	Hedgehog signaling pathway Axon guidance Pathways in cancer +6 more
		SNX29	Unknown	34778799	Open Targets	—
		SOCS1	Unknown	15327527	Open Targets	Ubiquitin mediated proteolysis Osteoclast differentiation JAK-STAT signaling pathway +13 more
		SOS1	Unknown	30013198 38212634 34778799	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +97 more
		SOX2	Unknown	34778799	Open Targets	Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation +4 more
		SPEN	Unknown	29253671 35986270	Open Targets	Notch signaling pathway
		SPOP	Unknown	34778799	Open Targets	Hedgehog signaling pathway Hedgehog 'on' state
		SS18	Unknown	29253671	Open Targets	ATP-dependent chromatin remodeling Transcriptional misregulation in cancer
		SS18L1	Unknown	26883104	Open Targets	ATP-dependent chromatin remodeling Transcriptional misregulation in cancer
		STAG1	Unknown	29795382 22237025 26438511	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		STAG2	Unknown	22649106 23832012 23955599 24056718 24067491 24335498 26438511 26728869 27276561 27288520 27435003 27470916 27881874 28063196 30013198 31942545 33618432 34070172 34301788 34778799 35805006 37002311 37102976 38212634	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		STAT3	Unknown	37002311	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway HIF-1 signaling pathway +53 more
		STAT5B	Unknown	34301788 19624718 34778799	Open Targets	ErbB signaling pathway Chemokine signaling pathway Hormone signaling +28 more
		STK11	Unknown	29795382	Open Targets	FoxO signaling pathway Hormone signaling Autophagy - animal +9 more
		STRN	Unknown	34778799	Open Targets	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling +2 more
		SUFU	Unknown	24056718	Open Targets	Hedgehog signaling pathway Pathways in cancer Basal cell carcinoma +4 more
		SUZ12	Unknown	37002311 38019014 22237025 24056718 34778799	Open Targets	Polycomb repressive complex PRC2 methylates histones and DNA Oxidative Stress Induced Senescence +5 more
		TCF3	Unknown	29253671 7734349 34778799	Open Targets	Signaling pathways regulating pluripotency of stem cells Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer +2 more
		TENT5C	Unknown	31648334 22237025	Open Targets	—
		TET1	Unknown	22237025 26438511 22976956	Open Targets	—
		TET2	Unknown	19295549 19474426 20489055 20678218 20693430 21042320 21343549 21637286 21828143 22017486 22071137 22116554 22234698 22390313 22431577 22520341 22976956 23135354 23613835 23702683 23753029 23832012 24036946 24045501 24859829 24898826 24931631 24994606 25022553 25241285 25381062 25381129 25412851 25652455 26414667 26438511 26728869 26941285 26980726 27029036 27063598 27276561 27288520 27359055 27435003 27458708 27798625 27881874 27908881 27997762 29417354 29795382 30013198 30355724 31145495 31184605 31187595 31232041 31648334 31827512 31942545 33054115 33099879 33161783 33618432 33711909 34070172 34132463 34492730 34778799 35805006 36672788 37002311 37102976 37853686 38204493 38212634	Open Targets	—
		TFE3	Unknown	29795382 31648334	Open Targets	Mitophagy - animal Transcriptional misregulation in cancer Renal cell carcinoma
		TFG	Unknown	34778799	Open Targets	Pathways in cancer Thyroid cancer COPII-mediated vesicle transport
		TNC	Unknown	25962120 24056718 34778799	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +6 more
		TP63	Unknown	34778799	Open Targets	MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes +5 more
		TPR	Unknown	34778799	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Pathways in cancer +27 more
		TRAF7	Unknown	38212634	Open Targets	Antigen processing: Ubiquitination & Proteasome degradation
		TRIM24	Unknown	22976956 34778799	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF fusions
		TRIM33	Unknown	34778799	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity
		TRRAP	Unknown	22976956	Open Targets	ATP-dependent chromatin remodeling Human T-cell leukemia virus 1 infection Formation of the beta-catenin:TCF transactivating complex +1 more
		TSC2	Unknown	27798625	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more
		TSHR	Unknown	22237025	Open Targets	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +6 more
		USP6	Unknown	26886259	Open Targets	—
		USP9X	Unknown	27798625 26941285 24036946 30013198	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes +2 more
		VAV1	Unknown	34778799	Open Targets	Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway +30 more
		VHL	Unknown	34070172	Open Targets	HIF-1 signaling pathway Ubiquitin mediated proteolysis Pathways in cancer +5 more
		VTI1A	Unknown	22237025 24056718	Open Targets	SNARE interactions in vesicular transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
		WIF1	Unknown	34778799	Open Targets	Wnt signaling pathway
		WNK2	Unknown	29253671 24036946 22237025 34778799	Open Targets	Parathyroid hormone synthesis, secretion and action Stimuli-sensing channels

Acute myeloid leukemia

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