Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
acute myeloid leukemia	MONDO_0018874 MONDO_0044923	ERG	Unknown	9549830 16737920 20694842 8187069 7533529 19781443 35986270 10354136 22237025 9242552 9096702 11340253	Open Targets	Transcriptional misregulation in cancer Prostate cancer
		ESR1	Unknown	22237025 24056718	Open Targets	Endocrine resistance Hormone signaling Estrogen signaling pathway +21 more
		ETNK1	Unknown	26886259 22237025 34778799	Open Targets	Glycerophospholipid metabolism Metabolic pathways Synthesis of PE
		ETV1	Unknown	22237025	Open Targets	Transcriptional misregulation in cancer
		EZH2	Unknown	20601953 20724984 22235851 22266912 22377896 22976956 23613835 23733339 23832012 24036946 24056718 24522528 25022553 25381129 25412851 25932436 26438511 26980726 27276561 27288520 27458708 27470916 27798625 27881874 27997762 30013198 30355724 31184605 33054115 33618432 33711909 34070172 34778799 35805006 37002311 37102976 38212634	Open Targets	Lysine degradation Metabolic pathways Polycomb repressive complex +7 more
		EZR	Unknown	22237025	Open Targets	Tight junction Leukocyte transendothelial migration Regulation of actin cytoskeleton +6 more
		FAM135B	Unknown	26941285 22237025	Open Targets	—
		FAM47C	Unknown	27798625 31648334	Open Targets	—
		FAT1	Unknown	27798625 22237025 24056718 24036946 26438511 27063598 34778799	Open Targets	—
		FAT3	Unknown	37305720 29795382 29253671 35986270 22237025 30013198 24056718 34778799	Open Targets	—
		FAT4	Unknown	27798625 25962120 22237025 26438511 34778799	Open Targets	Hippo signaling pathway - multiple species
		FBXO11	Unknown	9510473 31648334 22976956 27063598	Open Targets	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		FBXW7	Unknown	33020650 25962120 27288520 38212634 27276561	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		FCRL4	Unknown	22237025	Open Targets	—
		FES	Unknown	29253671	Open Targets	Axon guidance Signaling by SCF-KIT Sema3A PAK dependent Axon repulsion +1 more
		FGFR1	Unknown	37305720	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +32 more
		FGFR2	Unknown	22237025 34778799	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +26 more
		FGFR3	Unknown	26883104	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +27 more
		FH	Unknown	22237025	Open Targets	Citrate cycle (TCA cycle) Pyruvate metabolism Metabolic pathways +5 more
		FHIT	Unknown	34778799	Open Targets	Purine metabolism Metabolic pathways Small cell lung cancer +1 more
		FLNA	Unknown	26438511	Open Targets	MAPK signaling pathway Focal adhesion Salmonella infection +6 more
		FLT4	Unknown	22237025	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +6 more
		FNBP1	Unknown	34778799	Open Targets	Shigellosis Clathrin-mediated endocytosis
		FOXA1	Unknown	34778799	Open Targets	Estrogen-dependent gene expression
		FUBP1	Unknown	25962120	Open Targets	—
		FUS	Unknown	9549830 16737920 20694842 8187069 7533529 19781443 10354136 9242552 9096702 11340253	Open Targets	mRNA surveillance pathway Spliceosome Amyotrophic lateral sclerosis +3 more
		GATA1	Unknown	19260099 26728869 15916804 18830255 33020650 27288520 23733339 14656875 23153540 34301788 38212634 17023834 12172547 19119459 22389016 22294728 22296450 37002311 27470916 19452320 17597708 16631466 12586620 15180862 12649131 15070711 19633202 14684662 24056718 12747884 16012335 25266042 35805006	Open Targets	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		GLI1	Unknown	29253671 22237025 34778799	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Pathways in cancer +5 more
		GNAQ	Unknown	27460089	Open Targets	Rap1 signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +52 more
		GNAS	Unknown	29253671 27276561 30013198 27460089	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		GOLPH3	Unknown	34778799	Open Targets	—
		GOPC	Unknown	31648334	Open Targets	RHO GTPases regulate CFTR trafficking
		GPC3	Unknown	30013198	Open Targets	Proteoglycans in cancer A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis +9 more
		GPC5	Unknown	22237025	Open Targets	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation +7 more
		GPHN	Unknown	31648334 22237025	Open Targets	Folate biosynthesis Metabolic pathways Biosynthesis of cofactors +2 more
		GRIN2A	Unknown	24036946 22237025 30013198	Open Targets	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +19 more
		GRM3	Unknown	29253671	Open Targets	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +3 more
		H3-3A	Unknown	29795382 33020650	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +18 more
		H4C9	Unknown	31648334	Open Targets	Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis +33 more
		HGF	Unknown	34778799	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +29 more
		HIF1A	Unknown	27626069	Open Targets	HIF-1 signaling pathway Mitophagy - animal Autophagy - animal +19 more
		HNF1A	Unknown	27460089	Open Targets	Maturity onset diabetes of the young
		HNRNPA2B1	Unknown	34778799	Open Targets	Amyotrophic lateral sclerosis mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA +1 more
		HRAS	Unknown	22507781 22399013 27288520 35805006	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		IDH2	Unknown	20142433 20368543 20421455 20538800 20567020 20625116 20678218 20861910 20929327 20946881 20955413 20962861 21030981 21067377 21079611 21130701 21173122 21233841 21504050 21523797 21596855 21647152 21647154 21659357 21867611 21986839 21989985 21997850 22012066 22124213 22237025 22362118 22397365 22417203 22431577 22494415 22520341 22642896 22781800 22906848 22912701 22929312 23039322 23074281 23135354 23613835 23702683 23753029 23755812 23815907 23949315 24036946 24045501 24067491 24098815 24402164 24443894 24522528 24606448 24859829 24867525 24994606 25022553 25324972 25381129 25412851 25652455 25932436 25987093 26438511 26728869 26980726 27029036 27276561 27288520 27346558 27359055 27435003 27458708 27460089 27520294 27881874 28588019 29253671 29950729 30013198 30334576 30355724 31145495 31149783 31632056 31648334 31827512 31942545 32380538 33020650 33099879 33283233 33397455 33400143 33410163 33618432 33711909 33914060 34070172 34492730 34617422 34778799 35078972 35805006 35844705 35846058 36185232 36672788 37002311 37465589 37853686 38212634	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		IGF2BP2	Unknown	29795382	Open Targets	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
		IKZF1	Unknown	22649106 22976956 25331116 25962120 26941285 26980726 27470916 29253671 33618432 34778799 35805006 37002311 37794441 38212634	Open Targets	—
		IKZF3	Unknown	25962120 22237025	Open Targets	—
		IL7R	Unknown	23069254 26883104 38212634	Open Targets	Cytokine-cytokine receptor interaction FoxO signaling pathway PI3K-Akt signaling pathway +7 more
		IRS4	Unknown	27997762 26883104	Open Targets	cGMP-PKG signaling pathway FoxO signaling pathway Hormone signaling +11 more

Acute myeloid leukemia

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