Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
acute myeloid leukemia	MONDO_0018874	CCDC6	Unknown	34778799	Open Targets	Pathways in cancer Thyroid cancer
		CCND2	Unknown	27798625 29253671 26941285 38019014 22976956 31648334 34778799	Open Targets	FoxO signaling pathway Cell cycle p53 signaling pathway +18 more
		CCND3	Unknown	34301788 38212634 35986270 21399634	Open Targets	Cell cycle p53 signaling pathway PI3K-Akt signaling pathway +17 more
		CD74	Unknown	22237025	Open Targets	Antigen processing and presentation Tuberculosis Herpes simplex virus 1 infection +2 more
		CDC73	Unknown	25962120	Open Targets	Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state +3 more
		CDH10	Unknown	22237025	Open Targets	Adherens junctions interactions
		CDH11	Unknown	22237025	Open Targets	Adherens junctions interactions
		CDK12	Unknown	29795382 34778799	Open Targets	TP53 Regulates Transcription of DNA Repair Genes
		CDK6	Unknown	34778799	Open Targets	Cell cycle p53 signaling pathway PI3K-Akt signaling pathway +27 more
		CDKN1B	Unknown	34778799	Open Targets	Endocrine resistance ErbB signaling pathway HIF-1 signaling pathway +28 more
		CDKN2A	Unknown	37002311 7544647 9447829 7882348 7632963 23856246 22976956 8616035 7795238 37853686 27276561 27288520 7577621 7882134 22072402 34778799	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CHD2	Unknown	24036946	Open Targets	—
		CHD4	Unknown	29253671 34778799	Open Targets	ATP-dependent chromatin remodeling Human papillomavirus infection Viral carcinogenesis +5 more
		CLTC	Unknown	34778799	Open Targets	Lysosome Endocytosis Synaptic vesicle cycle +18 more
		CNBD1	Unknown	31648334	Open Targets	—
		CNTNAP2	Unknown	22237025	Open Targets	Cell adhesion molecules
		CNTRL	Unknown	27798625 22237025	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes +6 more
		COL3A1	Unknown	27798625	Open Targets	Platelet activation Cytoskeleton in muscle cells Relaxin signaling pathway +16 more
		CREBBP	Unknown	24523240 37002311 10706136 27798625 27470916 21390130 27276561 34301788 38212634	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +52 more
		CRTC1	Unknown	34778799	Open Targets	Human T-cell leukemia virus 1 infection Transcriptional activation of mitochondrial biogenesis Circadian Clock
		CSF1R	Unknown	2406720 2142747	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +10 more
		CSF3R	Unknown	11071667 11238134 12203110 12763135 18528462 19016735 19794089 19833857 22146088 22371884 23508011 23656643 24523240 25412851 25858548 26728869 27030388 27288520 27798625 29253671 30013198 34778799 34818692 35805006 37002311 37102976 38212634 7542747 8652369 9001427 9116280	Open Targets	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway +3 more
		CSMD3	Unknown	29253671 22237025 26883104 24056718 37305720	Open Targets	—
		CTCF	Unknown	37002311 29253671 22976956 23153540 22237025 24056718 38212634 21399634 34778799	Open Targets	—
		CTNNA2	Unknown	22237025 24056718	Open Targets	Hippo signaling pathway Adherens junction Leukocyte transendothelial migration +6 more
		CTNND1	Unknown	22976956	Open Targets	Rap1 signaling pathway Adherens junction Leukocyte transendothelial migration +3 more
		CTNND2	Unknown	25962120 22237025 34778799	Open Targets	Wnt signaling pathway
		CUL3	Unknown	22237025	Open Targets	Ubiquitin mediated proteolysis Hedgehog signaling pathway Degradation of DVL +4 more
		CUX1	Unknown	22237025 24316979 27276561 27288520 31184605 34778799 35805006 37002311 37853686	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Intra-Golgi traffic
		CXCR4	Unknown	27997762	Open Targets	Viral life cycle - HIV-1 Virion - Human immunodeficiency virus Calcium signaling pathway +15 more
		CYLD	Unknown	22976956	Open Targets	NF-kappa B signaling pathway Necroptosis Osteoclast differentiation +9 more
		CYP2C8	Unknown	25962120	Open Targets	Arachidonic acid metabolism Linoleic acid metabolism Retinol metabolism +10 more
		CYSLTR2	Unknown	22237025	Open Targets	Calcium signaling pathway Neuroactive ligand-receptor interaction Glucagon signaling in metabolic regulation +6 more
		DAXX	Unknown	22237025	Open Targets	MAPK signaling pathway Apoptosis Parkinson disease +6 more
		DCC	Unknown	27798625 31648334 22237025 30013198 34778799	Open Targets	Axon guidance Pathways in cancer Colorectal cancer +3 more
		DCTN1	Unknown	29795382 30013198 29253671	Open Targets	Motor proteins Vasopressin-regulated water reabsorption Amyotrophic lateral sclerosis +15 more
		DDR2	Unknown	21606962	Open Targets	Non-integrin membrane-ECM interactions
		DDX3X	Unknown	29795382 34778799	Open Targets	RIG-I-like receptor signaling pathway Hepatitis B Viral carcinogenesis +1 more
		DHX34	Unknown	32098966	Open Targets	—
		DICER1	Unknown	22237025	Open Targets	MicroRNAs in cancer MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
		DNM2	Unknown	37002311 27798625 33020650 34301788 22237025 34778799	Open Targets	Phospholipase D signaling pathway Endocytosis Fc gamma R-mediated phagocytosis +13 more
		EED	Unknown	27798625 22237025 34778799	Open Targets	Polycomb repressive complex PRC2 methylates histones and DNA Oxidative Stress Induced Senescence +4 more
		EGFR	Unknown	30013198 27460089	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses +79 more
		ELL	Unknown	19405140 7991593 8639852 23735562 22237025 22149207 25758097	Open Targets	Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events +4 more
		EML4	Unknown	17625570	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer +1 more
		EP300	Unknown	24523240 22371884 27798625 25962120 22976956 27276561 31648334 38212634 34778799	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +66 more
		EPAS1	Unknown	29795382 31648334 34070172	Open Targets	HIF-1 signaling pathway Pathways in cancer Renal cell carcinoma +6 more
		EPS15	Unknown	16826222 8134107	Open Targets	Endocytosis EGFR downregulation Negative regulation of MET activity +2 more
		ERBB2	Unknown	29253671 34778799	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +48 more
		ERBB4	Unknown	22237025 34778799	Open Targets	MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway +22 more

Acute myeloid leukemia

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