Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
acute myeloid leukemia	MONDO_0018874 MONDO_0044923	A1CF	Unknown	22237025 34778799	Open Targets	mRNA Editing: C to U Conversion Formation of the Editosome
		ABI1	Unknown	9694699 11477655	Open Targets	Pathogenic Escherichia coli infection Salmonella infection Regulation of actin dynamics for phagocytic cup formation +3 more
		ABL1	Unknown	10567681 11255282 12161353 17016044 21156255 22897847 23054652 25547655 25962120 26802623 27460089 35805006 35986270 7950925 8547143	Open Targets	ErbB signaling pathway Ras signaling pathway Cell cycle +17 more
		ACSL6	Unknown	24036946	Open Targets	Fatty acid biosynthesis Fatty acid degradation Metabolic pathways +7 more
		AFDN	Unknown	8242616 10719372 8950979 10886213 22976956 11587234 8703846 22307741	Open Targets	Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway +4 more
		AFF1	Unknown	19459927 20051780 27833093 8152249 8358709 34778799	Open Targets	Transcriptional misregulation in cancer
		AFF3	Unknown	22237025	Open Targets	—
		AFF4	Unknown	12759932	Open Targets	Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events +1 more
		AKT1	Unknown	27063598	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more
		ALK	Unknown	26032424 20428197 22237025 17625570	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		ANKRD26	Unknown	23926458 27895058 30466750 27069254	Open Targets	—
		APC	Unknown	27460089 22976956	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		APOBEC3B	Unknown	26883104	Open Targets	Viral life cycle - HIV-1 Human immunodeficiency virus 1 infection mRNA Editing: C to U Conversion +1 more
		ARHGAP26	Unknown	15382263 10908648 15852479	Open Targets	Rho GTPase cycle
		ARHGAP5	Unknown	22237025	Open Targets	Focal adhesion Leukocyte transendothelial migration Rho GTPase cycle
		ARHGEF10	Unknown	27798625 22237025	Open Targets	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
		ARHGEF10L	Unknown	29795382 22237025 30013198	Open Targets	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
		ARHGEF12	Unknown	10681437	Open Targets	Vascular smooth muscle contraction Axon guidance Platelet activation +12 more
		ARID1A	Unknown	27833093 25962120 34301788 38212634 24036946 26438511 26883104 27063598 34778799	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID2	Unknown	26438511 34778799	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		ASXL1	Unknown	19865112 20693432 21030981 21637286 22031865 22058207 22371884 22431577 22929312 23018865 23613835 23648668 23702683 23753029 23952244 24036946 24045501 24056718 24402164 24923295 25022553 25331116 25381062 25381129 25412851 25652455 25860235 26438511 26728869 26980726 27029036 27276561 27288520 27359055 27435003 27458708 27470916 27881874 27908881 27997762 28063196 29253671 29417354 29795382 30013198 31648334 31942545 32782768 33054115 33161783 33283233 33618432 33711909 34070172 34492730 34778799 35078972 35805006 37002311 37102976 38212634	Open Targets	Polycomb repressive complex UCH proteinases
		ASXL2	Unknown	37002311 27798625 35986270 34301788 38212634 26438511 34778799	Open Targets	Polycomb repressive complex UCH proteinases
		ATIC	Unknown	22237025	Open Targets	Purine metabolism One carbon pool by folate Metabolic pathways +2 more
		ATR	Unknown	27798625 22976956	Open Targets	Fanconi anemia pathway Cell cycle p53 signaling pathway +13 more
		ATRX	Unknown	26941285 26438511 27276561 35805006 27881874 34778799	Open Targets	Cell cycle
		AXIN1	Unknown	24056718	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		AXIN2	Unknown	30013198	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +15 more
		BARD1	Unknown	24036946	Open Targets	Homologous recombination HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) +11 more
		BAX	Unknown	30013198	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +52 more
		BCL10	Unknown	29253671	Open Targets	NF-kappa B signaling pathway C-type lectin receptor signaling pathway T cell receptor signaling pathway +8 more
		BCL11A	Unknown	30013198	Open Targets	—
		BCL11B	Unknown	25962120 21399634 34778799	Open Targets	Transcriptional misregulation in cancer
		BCL6	Unknown	37002311	Open Targets	FoxO signaling pathway Transcriptional misregulation in cancer Chemical carcinogenesis - receptor activation +3 more
		BCL9	Unknown	34778799	Open Targets	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
		BCL9L	Unknown	31648334	Open Targets	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
		BCLAF1	Unknown	22237025 34778799	Open Targets	—
		BCORL1	Unknown	21989985 25596268 25652455 25962120 26438511 26728869 26980726 27288520 27435003 27470916 27798625 27881874 28063196 29663558 30013198 34070172 35805006 37002311 37102976 37853686 38212634	Open Targets	Polycomb repressive complex
		BIRC6	Unknown	34778799	Open Targets	Ubiquitin mediated proteolysis Autophagy - animal Apoptosis - multiple species
		BRAF	Unknown	37002311 26728869 29795382 37102976 27470916 27276561 27288520 24571676 14603338 34778799	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA1	Unknown	22237025	Open Targets	Platinum drug resistance Homologous recombination Fanconi anemia pathway +19 more
		BRCA2	Unknown	31475115 37002311 26886259 30013198 38212634 34778799	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		BTG1	Unknown	22237025	Open Targets	RNA degradation FOXO-mediated transcription of cell cycle genes
		BUB1B	Unknown	25962120	Open Targets	Cell cycle Human T-cell leukemia virus 1 infection Inactivation of APC/C via direct inhibition of the APC/C complex +9 more
		CACNA1D	Unknown	34778799	Open Targets	MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +35 more
		CAMTA1	Unknown	22237025 24056718 34778799	Open Targets	—
		CASP8	Unknown	29191655	Open Targets	Platinum drug resistance p53 signaling pathway Apoptosis +53 more
		CBFA2T3	Unknown	27094503 24127550 23153540 23407549 24056718 27114462 23045605	Open Targets	—
		CBFB	Unknown	34778799	Open Targets	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Transcriptional regulation by RUNX2 RUNX1 regulates estrogen receptor mediated transcription +20 more
		CBLB	Unknown	37002311 27276561 17475912	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +5 more
		CBLC	Unknown	22976956 27063598	Open Targets	Ubiquitin mediated proteolysis Endocytosis

Acute myeloid leukemia

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