Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 281

8 diseases · 19 shared-gene connections
8 Diseases
19 Unique genes
0.263 Avg. similarity score
Autoimmune disease, multisystem, infantile-onset, 1 Most-connected disease (6 links)
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Disease Searched: Hyper-immunoglobulin e recurrent infection syndrome 1, autosomal dominant Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Autoimmune disease, multisystem, infantile-onset, 1 6 6 1
Early-onset multisystem autoimmune disease 6 6 1
Hyper-immunoglobulin e recurrent infection syndrome 1, autosomal dominant 6 6 1
Lymphoproliferative disorder of natural killer cells 6 6 1
Hyper-immunoglobulin e syndrome 5 5 4
Breast implant-associated anaplastic large cell lymphoma 4 4 6
Copper overload cirrhosis 4 4 11
Hyper-immunoglobulin e recurrent infection syndrome 3, autosomal recessive 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
STAT3 7 / 8 Autoimmune disease, multisystem, infantile-onset, 1, Breast implant-associated anaplastic large cell lymphoma, Copper overload cirrhosis, Early-onset multisystem autoimmune disease and 3 more
ZNF341 2 / 8 Hyper-immunoglobulin e recurrent infection syndrome 3, autosomal recessive, Hyper-immunoglobulin e syndrome
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Pathways in cancer
STAT3, BRCA2, JAK1, JAK2, TP53, CASP3, HGF, MET, SMAD2, TGFB1, IL6ST
 KEGG 11 / 533 13.0× 6.50e-11 8.02e-9 ✓ sig.
Proteoglycans in cancer
STAT3, TP53, CASP3, HGF, MET, SMAD2, TGFB1, ITGB3
 KEGG 8 / 204 24.8× 3.89e-10 3.98e-8 ✓ sig.
Pancreatic cancer
STAT3, BRCA2, JAK1, TP53, SMAD2, TGFB1
 KEGG 6 / 77 49.3× 1.45e-9 1.30e-7 ✓ sig.
Interleukin-27 signaling
STAT3, JAK1, JAK2, IL6ST
 Reactome 4 / 11 230× 1.47e-9 1.31e-7 ✓ sig.
Interleukin-6 signaling
STAT3, JAK1, JAK2, IL6ST
 Reactome 4 / 11 230× 1.47e-9 1.31e-7 ✓ sig.
Interleukin-35 Signalling
STAT3, JAK1, JAK2, IL6ST
 Reactome 4 / 12 211× 2.20e-9 1.89e-7 ✓ sig.
MET activates STAT3
STAT3, HGF, MET
 Reactome 3 / 3 632× 3.36e-9 2.79e-7 ✓ sig.
Interleukin-4 and Interleukin-13 signaling
STAT3, JAK1, JAK2, TP53, HGF, TGFB1
 Reactome 6 / 108 35.1× 1.13e-8 8.30e-7 ✓ sig.
Th17 cell differentiation
STAT3, JAK1, JAK2, SMAD2, TGFB1, IL6ST
 KEGG 6 / 109 34.8× 1.20e-8 8.70e-7 ✓ sig.
EGFR tyrosine kinase inhibitor resistance
STAT3, JAK1, JAK2, HGF, MET
 KEGG 5 / 80 39.5× 1.25e-7 6.81e-6 ✓ sig.
Hepatitis B
STAT3, JAK1, JAK2, TP53, CASP3, TGFB1
 KEGG 6 / 163 23.3× 1.34e-7 7.22e-6 ✓ sig.
MAPK1 (ERK2) activation
JAK1, JAK2, IL6ST
 Reactome 3 / 9 211× 2.80e-7 1.38e-5 ✓ sig.
Kaposi sarcoma-associated herpesvirus infection
STAT3, JAK1, JAK2, TP53, CASP3, IL6ST
 KEGG 6 / 196 19.4× 3.98e-7 1.87e-5 ✓ sig.
MAPK3 (ERK1) activation
JAK1, JAK2, IL6ST
 Reactome 3 / 10 190× 4.00e-7 1.88e-5 ✓ sig.
AGE-RAGE signaling pathway in diabetic complications
STAT3, JAK2, CASP3, SMAD2, TGFB1
 KEGG 5 / 101 31.3× 4.03e-7 1.89e-5 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
interleukin-6-mediated signaling pathway
STAT3, JAK1, JAK2, IL6ST
 GO:0070102 4 / 16 246× 1.38e-9 3.08e-7 ✓ sig.
positive regulation of vascular endothelial growth factor production
STAT3, BRCA1, TGFB1, IL6ST
 GO:0010575 4 / 32 123× 2.70e-8 4.19e-6 ✓ sig.
interleukin-11-mediated signaling pathway
STAT3, JAK1, IL6ST
 GO:0038154 3 / 7 422× 3.11e-8 4.74e-6 ✓ sig.
cellular response to ionizing radiation
BRCA1, BRCA2, TP53, TGFB1
 GO:0071479 4 / 41 96.0× 7.55e-8 1.00e-5 ✓ sig.
cell population proliferation
STAT3, BRCA2, TP53, MKI67, SMAD2, TGFB1
 GO:0008283 6 / 263 22.4× 1.71e-7 1.99e-5 ✓ sig.
T-helper 17 cell lineage commitment
STAT3, JAK1, IL6ST
 GO:0072540 3 / 13 227× 2.53e-7 2.76e-5 ✓ sig.
positive regulation of gene expression
STAT3, BRCA1, TP53, ACTA2, SMAD2, TGFB1, ITGB3
 GO:0010628 7 / 504 13.7× 3.79e-7 3.85e-5 ✓ sig.
growth hormone receptor signaling pathway via JAK-STAT
STAT3, JAK1, JAK2
 GO:0060397 3 / 15 197× 4.02e-7 4.05e-5 ✓ sig.
type II interferon-mediated signaling pathway
JAK1, JAK2, TP53
 GO:0060333 3 / 15 197× 4.02e-7 4.05e-5 ✓ sig.
cell surface receptor signaling pathway via JAK-STAT
STAT3, JAK1, JAK2, IL6ST
 GO:0007259 4 / 67 58.7× 5.62e-7 5.37e-5 ✓ sig.
response to X-ray
BRCA2, TP53, CASP3
 GO:0010165 3 / 19 155× 8.55e-7 7.53e-5 ✓ sig.
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
STAT3, JAK2
 GO:1902728 2 / 2 984× 9.79e-7 8.46e-5 ✓ sig.
response to antibiotic
JAK1, JAK2, TP53
 GO:0046677 3 / 21 141× 1.17e-6 9.78e-5 ✓ sig.
regulation of multicellular organismal process
JAK1, HGF, SMAD2
 GO:0051239 3 / 30 98.4× 3.56e-6 2.41e-4 ✓ sig.
transforming growth factor beta receptor signaling pathway
STAT3, TP53, SMAD2, TGFB1
 GO:0007179 4 / 112 35.1× 4.42e-6 2.87e-4 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Autoimmune disease, multisystem, infantile-onset, 1 Early-onset multisystem autoimmune disease 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Autoimmune disease, multisystem, infantile-onset, 1 Hyper-immunoglobulin e recurrent infection syndrome 1, autosomal dominant 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Autoimmune disease, multisystem, infantile-onset, 1 Lymphoproliferative disorder of natural killer cells 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Hyper-immunoglobulin e recurrent infection syndrome 1, autosomal dominant Lymphoproliferative disorder of natural killer cells 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Early-onset multisystem autoimmune disease Hyper-immunoglobulin e recurrent infection syndrome 1, autosomal dominant 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Early-onset multisystem autoimmune disease Lymphoproliferative disorder of natural killer cells 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Hyper-immunoglobulin e syndrome Lymphoproliferative disorder of natural killer cells 0.200 1 2.58e-4 5.38e-4 ✓ sig.
Hyper-immunoglobulin e recurrent infection syndrome 3, autosomal recessive Hyper-immunoglobulin e syndrome 0.200 1 2.58e-4 5.38e-4 ✓ sig.
Hyper-immunoglobulin e recurrent infection syndrome 1, autosomal dominant Hyper-immunoglobulin e syndrome 0.200 1 2.58e-4 5.38e-4 ✓ sig.
Early-onset multisystem autoimmune disease Hyper-immunoglobulin e syndrome 0.200 1 2.58e-4 5.38e-4 ✓ sig.
Autoimmune disease, multisystem, infantile-onset, 1 Hyper-immunoglobulin e syndrome 0.200 1 2.58e-4 5.38e-4 ✓ sig.
Breast implant-associated anaplastic large cell lymphoma Hyper-immunoglobulin e recurrent infection syndrome 1, autosomal dominant 0.167 1 3.23e-4 6.41e-4 ✓ sig.
Breast implant-associated anaplastic large cell lymphoma Early-onset multisystem autoimmune disease 0.167 1 3.23e-4 6.41e-4 ✓ sig.
Breast implant-associated anaplastic large cell lymphoma Lymphoproliferative disorder of natural killer cells 0.167 1 3.23e-4 6.41e-4 ✓ sig.
Autoimmune disease, multisystem, infantile-onset, 1 Breast implant-associated anaplastic large cell lymphoma 0.167 1 3.23e-4 6.41e-4 ✓ sig.
Copper overload cirrhosis Hyper-immunoglobulin e recurrent infection syndrome 1, autosomal dominant 0.083 1 7.10e-4 1.17e-3 ✓ sig.
Autoimmune disease, multisystem, infantile-onset, 1 Copper overload cirrhosis 0.083 1 7.10e-4 1.17e-3 ✓ sig.
Copper overload cirrhosis Early-onset multisystem autoimmune disease 0.083 1 7.10e-4 1.17e-3 ✓ sig.
Copper overload cirrhosis Lymphoproliferative disorder of natural killer cells 0.083 1 7.10e-4 1.17e-3 ✓ sig.