Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

← Back to all clusters

Cluster 350

6 diseases · 10 shared-gene connections
6 Diseases
30 Unique genes
0.237 Avg. similarity score
Cerebral saccular aneurysm Most-connected disease (4 links)
Log in to save this analysis

Save This Analysis

Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Cerebral saccular aneurysm 4 4 5
Connective and soft tissue disorder 4 4 1
Vascular ehlers-danlos syndrome 4 4 1
ehlers-danlos syndrome, vascular type 4 4 1
Nephrosclerosis 3 3 14
Intracranial aneurysm 1 1 15

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
COL3A1 5 / 6 Cerebral saccular aneurysm, Connective and soft tissue disorder, ehlers-danlos syndrome, vascular type, Nephrosclerosis and 1 more
ANGPTL6 2 / 6 Cerebral saccular aneurysm, Intracranial aneurysm
ENG 2 / 6 Cerebral saccular aneurysm, Intracranial aneurysm
THSD1 2 / 6 Cerebral saccular aneurysm, Intracranial aneurysm
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Interleukin-4 and Interleukin-13 signaling
BCL2, COL1A2, IL6, MMP2, MMP9, ALOX5, FGF2, TGFB1
 Reactome 8 / 108 29.7× 1.63e-10 2.26e-8 ✓ sig.
AGE-RAGE signaling pathway in diabetic complications
COL3A1, BCL2, COL1A2, IL6, MMP2, COL1A1, TGFB1
 KEGG 7 / 101 27.7× 4.19e-9 4.04e-7 ✓ sig.
Relaxin signaling pathway
COL3A1, COL1A2, MMP2, MMP9, ACTA2, COL1A1, TGFB1
 KEGG 7 / 130 21.6× 2.45e-8 1.93e-6 ✓ sig.
Collagen degradation
COL3A1, COL1A2, MMP2, MMP9, COL1A1
 Reactome 5 / 52 38.5× 1.64e-7 1.00e-5 ✓ sig.
Non-integrin membrane-ECM interactions
COL3A1, COL1A2, COL1A1, FGF2
 Reactome 4 / 24 66.7× 3.25e-7 1.84e-5 ✓ sig.
Diabetic cardiomyopathy
COL3A1, COL1A2, MMP2, MMP9, NCF1, COL1A1, TGFB1
 KEGG 7 / 205 13.7× 5.56e-7 2.94e-5 ✓ sig.
Collagen chain trimerization
COL3A1, COL1A2, COL22A1, COL1A1
 Reactome 4 / 44 36.4× 4.01e-6 1.58e-4 ✓ sig.
Amoebiasis
COL3A1, COL1A2, IL6, COL1A1, TGFB1
 KEGG 5 / 103 19.4× 5.06e-6 1.92e-4 ✓ sig.
Extracellular matrix organization
COL3A1, COL1A2, COL1A1
 Reactome 3 / 15 80.1× 6.27e-6 2.27e-4 ✓ sig.
Intestinal immune network for IgA production
IL6, CXCL12, CXCR4, TGFB1
 KEGG 4 / 50 32.0× 6.73e-6 2.41e-4 ✓ sig.
Assembly of collagen fibrils and other multimeric structures
COL3A1, COL1A2, MMP9, COL1A1
 Reactome 4 / 51 31.4× 7.29e-6 2.57e-4 ✓ sig.
ECM proteoglycans
COL3A1, COL1A2, VCAN, COL1A1
 Reactome 4 / 51 31.4× 7.29e-6 2.57e-4 ✓ sig.
Leukocyte transendothelial migration
MMP2, MMP9, NCF1, CXCL12, CXCR4
 KEGG 5 / 116 17.3× 9.06e-6 3.10e-4 ✓ sig.
Proteoglycans in cancer
COL1A2, MMP2, MMP9, COL1A1, FGF2, TGFB1
 KEGG 6 / 204 11.8× 9.43e-6 3.20e-4 ✓ sig.
Collagen biosynthesis and modifying enzymes
COL3A1, COL1A2, COL22A1, COL1A1
 Reactome 4 / 67 23.9× 2.17e-5 6.39e-4 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
response to hypoxia
ENG, TGFBR3, MMP2, CXCL12, CXCR4, MTHFR, TGFB1
 GO:0001666 7 / 176 24.8× 9.89e-9 1.69e-6 ✓ sig.
transforming growth factor beta receptor signaling pathway
COL3A1, ENG, TGFBR3, COL1A2, HIPK2, TGFB1
 GO:0007179 6 / 112 33.4× 2.14e-8 3.31e-6 ✓ sig.
positive regulation of vasculature development
CXCL12, CXCR4, TGFB1
 GO:1904018 3 / 5 374× 3.73e-8 5.27e-6 ✓ sig.
heart development
COL3A1, ENG, MMP2, PKD1, PKD2, SOX17, TGFB1
 GO:0007507 7 / 273 16.0× 2.01e-7 2.18e-5 ✓ sig.
positive regulation of smooth muscle cell proliferation
IL6, MMP2, FGF2, TGFB1
 GO:0048661 4 / 52 47.9× 1.38e-6 1.07e-4 ✓ sig.
cellular response to amino acid stimulus
COL3A1, COL1A2, MMP2, COL1A1
 GO:0071230 4 / 64 38.9× 3.21e-6 2.11e-4 ✓ sig.
regulation of cell cycle
BCL2, PKD1, PKD2, FGF2, HIPK2, TGFB1
 GO:0051726 6 / 262 14.3× 3.21e-6 2.11e-4 ✓ sig.
cellular response to transforming growth factor beta stimulus
TGFBR3, ACTA2, COL1A1, TGFB1
 GO:0071560 4 / 67 37.2× 3.86e-6 2.44e-4 ✓ sig.
blood vessel development
COL3A1, COL1A2, PKD1, COL1A1
 GO:0001568 4 / 70 35.6× 4.60e-6 2.81e-4 ✓ sig.
cell migration
ENG, TGFBR3, BCL2, MMP2, MMP9, CXCR4
 GO:0016477 6 / 303 12.3× 7.40e-6 4.11e-4 ✓ sig.
positive regulation of gene expression
TGFBR3, IL6, PKD2, SOX17, ACTA2, FGF2, TGFB1
 GO:0010628 7 / 504 8.7× 1.18e-5 5.94e-4 ✓ sig.
animal organ regeneration
TGFBR3, CXCL12, TGFB1
 GO:0031100 3 / 28 66.7× 1.19e-5 5.97e-4 ✓ sig.
metanephric ascending thin limb development
PKD1, PKD2
 GO:0072218 2 / 4 311× 1.49e-5 7.15e-4 ✓ sig.
positive regulation of cell population proliferation
BCL2, IL6, KMT2D, CXCL12, FGF2, HIPK2, TGFB1
 GO:0008284 7 / 532 8.2× 1.68e-5 7.83e-4 ✓ sig.
face morphogenesis
MMP2, COL1A1, TGFB1
 GO:0060325 3 / 33 56.6× 1.97e-5 8.88e-4 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Cerebral saccular aneurysm Intracranial aneurysm 0.167 3 7.47e-9 6.56e-8 ✓ sig.
Connective and soft tissue disorder Vascular ehlers-danlos syndrome 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Connective and soft tissue disorder ehlers-danlos syndrome, vascular type 0.500 1 6.49e-5 2.34e-4 ✓ sig.
ehlers-danlos syndrome, vascular type Vascular ehlers-danlos syndrome 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Cerebral saccular aneurysm Connective and soft tissue disorder 0.167 1 3.25e-4 7.58e-4 ✓ sig.
Cerebral saccular aneurysm Vascular ehlers-danlos syndrome 0.167 1 3.25e-4 7.58e-4 ✓ sig.
Cerebral saccular aneurysm ehlers-danlos syndrome, vascular type 0.167 1 3.25e-4 7.58e-4 ✓ sig.
Connective and soft tissue disorder Nephrosclerosis 0.067 1 9.09e-4 1.56e-3 ✓ sig.
ehlers-danlos syndrome, vascular type Nephrosclerosis 0.067 1 9.09e-4 1.56e-3 ✓ sig.
Nephrosclerosis Vascular ehlers-danlos syndrome 0.067 1 9.09e-4 1.56e-3 ✓ sig.